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Stem Cell Biology of the Inner Ear and Potential Therapeutic Applications

  • Chapter
Adult Stem Cells

Abstract

The mammalian inner ear is composed of two sensory receptor areas: the cochlea, responsible for translating auditory stimuli, and the vestibule, responsible for a sense of balance. The bilateral inner ears of mammals develop from a pair of thickened branchial ectodermal placodes that invaginate for sequential formation of otic pits, otocysts, and then complete membranous labyrinths (1). During development of inner ear sensory epithelium, several phenotypes of sensory and nonsensory cells differentiate (i.e., hair cells, support cells, glia, and neurons).

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Authors
  1. Thomas R. Van De Water
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  2. Ken Kojima
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  3. Ichiro Tateya
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  4. Juichi Ito
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  5. Brigitte Malgrange
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  6. Philippe P. Lefebvre
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  7. Hinrich Staecker
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  8. Mark F. Mehler
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Editors and Affiliations

  1. Hormones, Growth, and Development Program, Ottawa Health Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada

    Kursad Turksen

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Van De Water, T.R. et al. (2004). Stem Cell Biology of the Inner Ear and Potential Therapeutic Applications. In: Turksen, K. (eds) Adult Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-732-1_14

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  • DOI: https://doi.org/10.1007/978-1-59259-732-1_14

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-392-3

  • Online ISBN: 978-1-59259-732-1

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