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From Marrow to Brain

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Adult Stem Cells

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Abstract

All organisms originate from a single totipotent cell. During development, the progeny of this cell become increasingly restricted in their differentiation potential. Nevertheless, most cells retain an intact genome, and the selective expression or repression of genes determines specific properties. In recent years, it has become evident that adult cells can thus be reprogrammed back to totipotency (1). Moreover, stem cells that reside in adult tissues have the capacity to self-renew and to generate several types of differentiated progeny. These stem cells do not appear to be restricted to generating only cells of their original tissue, but show remarkable plasticity when exposed to an environment that they usually would not encounter. It has thus been suggested that a stem cell is not necessarily a specific cellular entity, but rather a function that can be assumed by numerous diverse cell types (2).

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Authors
  1. Josef Priller
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Editors and Affiliations

  1. Hormones, Growth, and Development Program, Ottawa Health Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada

    Kursad Turksen

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Priller, J. (2004). From Marrow to Brain. In: Turksen, K. (eds) Adult Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-732-1_11

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  • DOI: https://doi.org/10.1007/978-1-59259-732-1_11

  • Publisher Name: Humana Press, Totowa, NJ

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