Abstract
Accurate identification of acute cardiac ischemia (ACI) in the emergency department (ED) remains a task that challenges the skill of the most seasoned clinician, even though angina pectoris was described in great detail more than 200 years ago by Heberden (1) and the presentation of acute myocardial infarction (AMI) was first reported 85 years ago by Herrick (2). Each year in the United States, over 6 million patients with chest pain or Imminent Myocardial Infarction Rotterdam (IMIR) Study (3) inclusion symptoms present to EDs (4), and approximately 25% of these will have ACI. Physicians have the task of identifying, treating, and hospitalizing (in the appropriate unit) the approximately one-third of these patients who have true ACI (5) (i.e., either AMI or unstable angina pectoris [UAP]), to avoid filling hospital telemetry, stepdown units, and coronary care units with the large majority of patients who do not have ACI.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Heberden W. Some accounts of a disorder of the breast. Med Trans R Coll Phys Lond, 1772.
Herrick JB. Clinical features of sudden obstruction of the coronary arteries. JAMA 1912; 59: 2015–2020.
Van de Does E, Lubson J, Pool J, et al. Acute coronary events in a general practice: objectives and design of the Imminent Myocardial Infarction Rotterdam Study. Heart Bull 1976; 7: 91.
McCaig L, National Hospital Ambulatory Care Survey. 1992 Emergency department summary. Advanced Data 1994; 245: 1–12.
Pozen MW, D’Agostino RB, Selker HP, Sytkowski PA, Hood WB Jr. A predictive instrument to improve coronary care unit admission practices in acute ischemic heart disease: a prospective multicenter clinical trial. N Engl J Med 1984; 310: 1273–1278.
Goldman L, Weinberg M, et al. A computer-derived protocol to aid in the diagnosis of emergency room patients with acute chest pain. N Engl J Med 1982; 307: 588–596.
Schor S, Behar S, Modan B, Drory J, Kariv I. Disposition of presumed coronary patients from an emergency room: a follow-up study. JAMA 1976; 236: 941–943.
Lee TH, Rouan GW, Weisberg MC, et al. Clinical characteristics and natural history of patients with acute myocardial infarction sent home from the emergency room. Am J Cardiol 1987; 60: 219–224.
Pozen MW, D’Agostino RB, Mitchell JB, et al. The usefulness of a predictive instrument to reduce inappropriate admissions to the coronary care unit. Ann Intern Med 1980; 92: 238–242.
Selker HP, Pozen MW, D’Agostino RB. Optimal identification of the patient with acute myocardial ischemia in the emergency room. In: Calif RM, Wagner GS, eds. Acute Coronary Care: Principles and Practice. Martinus Nijhoff, Boston, 1985, pp. 289–298.
Bloom B, Peterson O. End results, costs, and productivity of coronary care units. N Engl J Med 1973; 288: 72–78.
Eisenberg JM, Horowitz LN, Busch R, Aryan D, Rawnsley H. Diagnosis of acute myocardial infarction in the emergency room: a prospective assessment of clinical decision making and the usefulness of immediate cardiac enzyme determination. J Community Health 1979; 4: 190–198.
Fuchs R, Scheidt S. Improved criteria for admission to cardiac care units. JAMA 1981; 246: 2037–2041.
Tierney WM, Roth BJ, Psaty B, et al. Predictors of myocardial infarction in emergency room patients. Crit Care Med 1985; 13: 526–531.
Goldman L, Cook EF, Brand DA, et al. A computer protocol to predict myocardial infarction in emergency department patients with chest pain. N Engl J Med 1988; 318: 707–803
McCarthy BD, Beshansky JR, D’Agostino RB, Selker HP. Missed diagnoses of acute myocardial infarction in the emergency department: results from a multicenter study. Ann Emerg Med 1993; 22: 579–582.
NIH National Heart Attack Alert Program Working Group on the Diagnosis of Acute Cardiac Ischemia Report. Ann Emerg Med 1997; 29: 1–87.
McCarthy BD, Wong JB, Selker HP. Detecting acute cardiac ischemia in the emergency department: a review of the literature. J Gen Intern Med 1990; 5: 365–373.
Rifkin RD, Hood WB Jr. Bayesian analysis of electrocardiographic exercise stress testing. N Engl J Med 1979; 297: 681–686.
Uretsky BF, Farquhar DS, Berezin AF, Hood WB Jr. Symptomatic myocardial infarction without chest pain: prevalence and clinical course. Am J Cardiol 1977; 40: 498–503.
Kinlen LJ. Incidence and presentation of myocardial infarction in an English community. Br Heart J 1973; 35: 616–622.
Margolis JR, Kannel WB, Feinlieb M, Dawber TR, McNanara PM. Clinical features of unrecognized myocardial infarction-silent and symptomatic. Eighteen year follow-up: the Framingham Study. Am J Cardiol 1973; 32: 1–6.
Selker HP, Beshansky JR, Griffith JL, et al. The use of the ACI-TIPI to assist emergency department triage of patients with chest pain of other symptoms suggestive of acute cardiac ischemia: a multicenter controlled clinical trial. Ann Intern Med 1998; in press.
Russell RO, et al. Unstable angina pectoris: National Cooperative Study Group to compare medical and surgical therapy: IV. Results in patients with left anterior descending coronary artery disease. Am J Cardiol 1981; 48: 517–524.
Krause KR, Hutter AM Jr, DeSanctis RW. Acute coronary insufficiency. Course and follow-up. Circulation 1972; 45 and 46(suppl I ): 166–171.
Wasson JH, Sox HC, Neff RK, Goldman L. Clinical prediction rules: applications and methodological standards. N Engl J Med 1985; 313: 793–799.
Pope JH, Ruthazev R, Beshansky JR, et al. The clinical presentation of patients with acute cardiac ischemia in the emergency department: a multicenter controlled clinical trial. J Thromb Thrombolysis 1998; 6: 63–74.
Short D. Diagnosis of slight and subacute coronary attacks in the community. Br Heart J 1981; 45: 299–310.
Lee TH, Cook F, Weisberg M, Sargent RK, Wilson C, Goldman L Acute chest pain in the emergency room: identification and examination of low-risk patients. Arch Intern Med 1985; 145: 65–69.
Sawe U. Pain in acute myocardial infarction. A study of 137 patients in a coronary care unit. Acta Med Scand 1971; 190: 79–81.
Sawe U. Early diagnosis of acute myocardial infarction with special reference to the diagnosis of the intermediate coronary syndrme: a clinical study. Acta Med Scand 1972; 520 (suppl): 1–76.
Levene DL. Chest pain-prophet of doom or nagging neurosis? Acta Med Scand 1981; 644 (suppl): 11–13.
Sievers J. Myocardial infarction. Clinical features and outcome in three thousand thirty-six cases. Acta Med Scand 1964; 406 (suppl): 1–120.
Areskog M, Tibbling L, Wranne B. Oesophageal dysfunction in non-infarction coronary care unit patients. Acta Med Scand 1979; 205: 279–282.
Alonzo AA, Simon AB, Feilieb M. Prodromata of myocardial infarction and sudden death. Circulation 1975; 52: 1056–1062.
Nattel S, Wamica JW, Ogilivie RI. Indications for admission to a coronary care unit in patients with unstable angina. Can Med Assoc J 1980; 122: 180–184.
Ingram DA, Fulton RA, Portal RW, P’Aber C. Vomiting as a diagnostic aid in acute ischemic cardiac pain. BMJ 1980; 281: 636–637.
Kannel WB, Abbott RD. Incidence and prognosis of unrecognized myocardial infarction: an update on the Framingham Study. N Engl J Med 1984; 311: 1144–1147.
Rosenman RH, Friedman M, Jenkins CD, et al. Clinically unrecognized myocardial infarction in the Western Collaborative Group Study. Am J Cardiol 1967; 19: 776–782.
Grimm RH, Tillinghast S, Daniels K, et al. Unrecognized myocardial infarction: experience in the Multiple Risk Factor Intervention Trisal (MRFIT). Circulation 1987; 75 (suppl II): 116–118.
Kannel WB. Unrecognized myocardial infarction. Prim Cardiol 1986;Jan:93–103.
McCarthy BD, Beshansky JR, D’ Agostino RB, Selker HP. Can missed diagnoses of acute myocardial infarction in the emergency room be reduced? Clin Res 1989; 37: 779A.
Gordon T, Sorlie P, Kannel WB. Coronary Heart Disease, Atherothrombotic Brain Infarction, Intermittent Claudication-A Multivariate Analysis of Some Factors Related to Their Incidence: Framingham Study, 16-Year Follow-up. US Government Printing Office, Washington, 1971.
Truett J, Cornfield J, Kannel W. A multivariate analysis of the risk of coronary heart disease in Framingham. J Chron Dis 1967; 20: 511–524.
Jayes RL, Beshansky JR, D’Agostino RB, et al. Do patients’ coronary risk factor reports predict acute cardiac ischemia in the emergency department? A multicenter study. J Clin Epidemiol 1992; 45: 621–626.
Orlando RC, Bozymski EM. Clinical and manometric effects of nitroglycerin in diffuse esophageal spasm. N Engl J Med 1973; 289: 23–25.
Killip T, Kimball JT. Treatment of myocardial infarction in a coronary care unit. A two year experience with 250 patients. Am J Cardiol 1967; 20: 457–464.
Selker HP, Griffith JL, D’Agostino RB. A time-insensitive predictive instrument for acute myocardial infarction mortality: a multicenter study. Med Care 1991; 29: 1196–1211.
Selker HP. Electrocardiograms and decision aids in coronary care triage: the truth but not the whole truth. J Gen Intern Med 1987; 2: 67–70.
Hoffman JR, Igarashi E. Influence of electrocardiographic findings on admission decisions in patients with acute chest pain. Am J Med 1985; 79: 699–707.
Brush JE Jr, Brand DA, Acampora D, Chalmer B, Wackers FJ. Use of the initial electrocardiogram to predict in-hospital complications of acute myocardial infarction. N Engl J Med. 1985; 312: 1137–1141.
Slater DK, Hlatky MA, Mark DB, Harrell FE Jr, Pryor DB, Califf RM. Outcome in suspected acute myocardial infarction with normal or minimally abnormal admission electrocardiographic findings. Am J Cardiol 1987; 60: 766–770.
Stark ME, Vacek JL. The initial electrocardiogram during admission for myocardial infarction; use as a predictor of clinical course and facility utilization. Arch Intern Med 1987; 147: 843–846.
Rude RE, Poole WK, Muller JE, et al. Electrocardiographic and clinical criteria for recognition of acute myocardial infarction based on analysis of 3,697 patients. Am J Cardiol 1983; 52: 936–942.
Lopez-Sendon J, Coma-Canella I, Alcasena S, et al. Electrocardiograhpic findings in acute right ventricular infarction: sensitivity and specificity of electrocardiographic alterations in right precordial leads V4R, V5R, V1,V2, and V3. J Am Coll Cardiol 1985; 19: 1273–1279.
Wrenn KD, Protocols in the emergency room evaluation of chest pain: do they fail to diagnose lateral wall myocardial infarction? J Gen Intern Med 1987; 2: 66–67.
Nestico PF, Hakki AH, Iskandrian AS, et al. Electrocardiographic diagnosis of posterior myocardial infarction revisited. J Electrocardiol 1986; 19: 33–40.
Fisch C. Electrocardiography, exercise stress testing, and ambulatory monitoring. In: Kelley WN, ed. Textbook of Internal Medicine. Lippincott, Philadelphia, 1989, pp. 305–316.
Jayes RL, Larsen GC, Beshansky JR, et al. Physician electrocardiogram reading in the emergency department: accuracy and effect on triage decisions: findings from a multicenter study. J Gen Intern Med. 1992; 7: 387–392.
Rusnak RA, Stair TO, Hansen K, et al. Litigation against the emergency physician: common features in cases of missed myocardial infarction. Ann Emerg Med 1989; 18: 1029–1034.
Griner PF, Mayewski RJ, Mushlin AI, Greenland P. Selection and interpretation of diagnostic tests and procedures: principles and applications. Ann Intern Med 1981; 94: 557–592.
Selker HP. Sorting out chest pain: identifying acute cardiac ischemia in the emergency room setting, an approach based on the acute ischemia heart disease predictive instrument. Emerg Decisions 1985; 1: 8–17.
Bell MR, Montarello JK, Steele PM. Does the emergency room electrocardiogram identify patients with suspected myocardial infarction who are at low risk of acute complications? Aust N Z J Med 1990; 20: 564–569.
Zalenski RJ, Sloan EP, Chen EH, et al. The emergency department ECG and immediate life-threatening complications in initially uncomplicated suspected myocardial ischemia. Ann Emerg Med 1988; 17: 221–226.
Cohen M, Hawkins L, Greenburg S, et al. Usefulness of ST-segment changes in *_2 leads on the emergency room electrocardiogram in either unstable angina pectoris of non-Q-wave myocardial infarction in predicting outcome. Am J Cardiol 1991; 67: 1368–1373.
Fesmire FM, Percy RF, Wears RL, MacMath TL. Initial ECG in Q-wave and non-Q-wave myocardial infarction. Ann Emerg Med 1989; 18: 741–746.
Rubenstein LZ, Greenfield S. The baseline ECG in the evaluation of acute cardiac complaints. JAMA 1980; 244: 2536–2539.
Miller DH, Kligfield P, Schreiber TL, Borer JS. Relationship of prior myocardial infarction to false-positive electrocardiographic diagnosis of acute injury in patients with chest pain. Arch Intern Med 1987; 147: 257–261.
Goldberger AL. Myocardial Infarction Electrocardiographic Differential Diagnosis, 2nd ed. CV Mosby, St. Louis, 1979.
Granborg J, Grande P, Pederson A. Diagnostic and prognostic significance of transient isolated negative T waves in suspected acute myocardial infarction. Am J Cardiol 1986; 57: 203–207.
Fisch C. Abnormal ECG in clinically normal individuals. JAMA 1983; 250: 1321–1323.
DeWood MA, Stifer WF, Simpson CS, et al. Coronary arteriographic findings soon after non-Q-wave myocardial infarction. N Engl J Med 1986; 315: 417–423.
Kennedy JW. Non-Q-wave myocardial infarction. N Engl J Med 1986; 315: 451–453.
Behar S, Schor S, Kariv I, et al. Evaluation of electrocardiogram in emergency room as a decision-making tool. Chest 1977; 71: 486–491.
McGuinness JB, Begg TB, Semple T. First electrocardiogram in recent myocardial infarction. BMJ 1976; 2: 449–451.
Jayes RL, Beshansky JR, D’Agostino RB, et al. Do patients’ coronary risk factor reports predict acute cardiac ischemia in the emergency department? A multicenter study. J Clin Epidemiol 1992; 45: 621–626.
Truett J, Cornfield J, Kannel W. A multivariate analysis of the risk of coronary heart disease in Framingham. J Chron Dis 1967; 20: 511–524.
Selker HP, Griffith JL, D’Agostino RB. A time-insensitive predictive instrument for acute myocardial infarction mortality: A multicenter study. Medical Care 1991; 29: 1196–1211.
Selker HP, et al. Patient-specific predictions of outcomes in myocardial infarction for real-time emergency use: a thrombolytic predictive instrument. Ann Intern Med 1998… in press.
Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J 1986; 111: 383–390.
Smith WC, Kenicer MB, et al. Prevalence of coronary heart disease in Scotland: Scottish Heart Health Study. Br Heart J 1990; 64: 295–298.
Elveback LR, Connolly DC. Coronary heart disease in residents of Rochester, Minnesota, V: prognosis of patients with CAD based on initial manifestation. Mayo Clin Proc 1985; 60: 305–331.
Seeman T, Mendes deLeon C, et al. Risk factors for coronary heart disease among older men and women: a prospective study of community-dwelling elderly. Am J Epidemiol 1993; 138: 1037–1049.
Maynard C, Weaver WD. Treatment of women with acute MI: new findings from the MITI Registry. J Myocard Ischemia 1992; 4: 27–37.
Sharpe PA, Clark NM, Janz NK. Differences in the impact and management of heart disease between older women and men. Women Health 1991; 17: 25–34.
Sullivan AK, Holdright DR, Wright CA, et al. Chest pain in women: clinical, investigative and prognostic features. BMJ 1994; 308: 883–886.
Cunningham MA, Lee TH, Cook EF, et al. The effect of gender on the probability of myocardial infarction among emergency department patients with acute chest pain. J Gen Intern Med 1989; 4: 392–398.
Liao Y, Lui K, Dyer A, et al. Sex differential in the relationship of electrocardiographic ST-T abnormalities to risk of coronary death: 11.5 year follow-up findings of the Chicago heart association detection project in industry. Circulation 1987; 75: 347–352.
Lusiani L, Perrone A, et al. Prevalence, clinical features and acute course of atypical myocardial infarction. Angiology 1994; 45: 49–55.
Fiebach, NH, Viscoli CM, Horwitz RI. Differences between women and men in survival after myocardial: biology or methodology? JAMA 1990; 263: 10922–10926.
Dittrich H, Gilpin E, Nicod P, et al. Acute myocardial infarction in women: influence of gender on mortality and prognostic variables. Am J Cardiol 1988; 62: 1–7.
Murabito, JM, Anderson KM, et al. Risk of coronary heart disease in subjects with chest discomfort: the Framingham Heart Study. Am J Med 1990; 89: 297–302.
Zucker DR, Griffith JL, et al. Presentations of acute myocardial infarction in men and women. J Gen Intern Med 1997; 12: 79–87.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media New York
About this chapter
Cite this chapter
Pope, J.H., Selker, H.P. (1999). Identifying Acute Cardiac Ischemia in the Emergency Department. In: Cannon, C.P. (eds) Management of Acute Coronary Syndromes. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-731-4_5
Download citation
DOI: https://doi.org/10.1007/978-1-59259-731-4_5
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4757-5706-4
Online ISBN: 978-1-59259-731-4
eBook Packages: Springer Book Archive