Triggers of Acute Coronary Syndromes

  • Peter M. Sapin
  • James E. Muller
Part of the Contemporary Cardiology book series (CONCARD)


The likelihood that acute myocardial infarction (MI) is triggered by a specific event has been a subject of debate since the earliest description of this disorder, which incorporated the belief that specific physical or mental events precipitated the attack (1). Controversy over the precipitating events continued for decades (2–3), until 1960, when Master (4) published a retrospective study of over 2600 patients with acute MI (4). This study was the largest to address MI triggers up to that time. Although no formal statistical analysis was applied, it was concluded from the data that the onset was unrelated to physical effort, time of day, day of the week, or the occupation of the patient. In the last 15 years, as knowledge of the pathologic processes underlying acute coronary syndromes has advanced, the possibility of the existence of specific triggers for the onset of acute MI and related syndromes has been reconsidered.


Acute Coronary Syndrome Heart Rate Variability Acute Myocardial Infarction Sudden Cardiac Death Circadian Variation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Peter M. Sapin
  • James E. Muller

There are no affiliations available

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