Antithrombotic Therapy in Unstable Angina and Non-Q-Wave Myocardial Infarction

  • Marc Cohen
  • Reginald Blaber
Part of the Contemporary Cardiology book series (CONCARD)


Unstable angina is a broad term representing a wide spectrum of ischemic coronary syndromes, ranging from progressive or accelerating angina to the high-risk subset of patients with rest angina and reversible electrocardiographic (ECG) changes. The underlying precipitant is the ruptured or fissured coronary plaque, which elicits a complex interaction between the coagulation cascade and platelets to form a thrombus. The majority of these disruptions and resulting thrombi cause only insignificant obstruction to coronary blood flow. However, a large thrombus can cause a significant impediment to coronary flow, resulting in ischemia. This thrombus may resolve spontaneously, with restoration of blood flow, or may propagate to cause further ischemia. Often this process can lead to complete occlusion of the vessel, precipitating a myocardial infarction (MI) (1–10). Unstable angina and non-Q-wave myocardial infarction (NQMI) represent two different points within the continuum of coronary thrombosis.


Unstable Angina Deep Venous Thrombosis Unfractionated Heparin Antithrombotic Therapy Direct Thrombin Inhibitor 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Marc Cohen
  • Reginald Blaber

There are no affiliations available

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