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Management of Acute Coronary Syndromes pp 293–336Cite as

Antiplatelet and Antithrombotic Therapy

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Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

The contemporary pharmacologic treatment of acute myocardial infarction (AMI) includes reperfusion via a thrombolytic agent as well as adjunctive therapy with aspirin and heparin (1). Despite the advances made, current management is limited by the fact that infarct-related artery patency is achieved in only 60–80% of patients at 90 min and Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow is achieved in only 30–55% of patients (2). Moreover, even after successful thrombolysis, reocclusion occurs in 5–10% of patients and is associated with increased morbidity and mortality (2, 3).

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Authors
  1. Marc S. Sabatine MD
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  2. Ik-Kyung Jang MD
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Editors and Affiliations

  1. Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Christopher P. Cannon MD

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© 1999 Springer Science+Business Media New York

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Sabatine, M.S., Jang, IK. (1999). Antiplatelet and Antithrombotic Therapy. In: Cannon, C.P. (eds) Management of Acute Coronary Syndromes. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-731-4_12

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  • DOI: https://doi.org/10.1007/978-1-59259-731-4_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5706-4

  • Online ISBN: 978-1-59259-731-4

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