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Bax, a Death Effector Molecule

Its Role in Development and Oncogenesis

  • Chapter
Apoptosis and Cancer Chemotherapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Bax is a member of the Bcl-2 family that regulates apoptosis by promoting cell death. Abnormal expression of this protein has been linked to pathological features such as colorectal cancer, enhanced tumorigenesis, and male sterility. Currently, the molecular mechanism by which Bax regulates apoptosis is unknown, despite intensive investigation of a variety of proposed models. Emerging evidence suggests that Bax can undergo differential conformational changes, and that its site of action appears to reside in mitochondria.

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Authors
  1. Yi-Te Hsu PhD
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  2. Richard Youle PhD
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Editor information

Editors and Affiliations

  1. Cancer Research Campaign, Molecular and Cellular Pharmacology Group, School of Biological Sciences, University of Manchester, UK

    John A. Hickman  & Caroline Dive  & 

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Hsu, YT., Youle, R. (1999). Bax, a Death Effector Molecule. In: Hickman, J.A., Dive, C. (eds) Apoptosis and Cancer Chemotherapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-720-8_8

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  • DOI: https://doi.org/10.1007/978-1-59259-720-8_8

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-165-3

  • Online ISBN: 978-1-59259-720-8

  • eBook Packages: Springer Book Archive

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