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Drug Resistance and the Survival Niche

Survival Signals Combine to Suppress Drug-Induced Apoptosis in B-Lymphoma Cells

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Apoptosis and Cancer Chemotherapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Studies of tumor cell lines in vitro suggest that the suppression of drug-induced apoptosis may be an important drug-resistance mechanism applicable to all types of anticancer agents that are used in vivo. Drug-induced apoptosis may be suppressed by overexpression of antiapoptotic proteins such as Bd-2, and/or by survival signals in the tumor microenvironment. These signals include the action of growth factors, cell—cell interactions, and interactions of cells with extracellular matrix. In vivo, tumor cells are likely to receive a combination of these signals from within their microenvironment. These survival signals may be heterogeneously distributed, and some cells may therefore exist in what could be termed a survival niche; others may be more vulnerable to apoptosis, including that induced by anticancer agents. The emergence of a viable and drug-resistant subpopulation of tumor cells following drug treatment may therefore depend on the signals derived from within a particular survival niche. This chapter focuses on the survival niche, in which drug-resistant B-cell lymphomas may reside, and describes attempts to create this cellular environment in vitro.

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Authors
  1. Sian T. Taylor BsC, PhD
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  2. Caroline Dive BPharm, PhD
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Editors and Affiliations

  1. Cancer Research Campaign, Molecular and Cellular Pharmacology Group, School of Biological Sciences, University of Manchester, UK

    John A. Hickman  & Caroline Dive  & 

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© 1999 Springer Science+Business Media New York

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Taylor, S.T., Dive, C. (1999). Drug Resistance and the Survival Niche. In: Hickman, J.A., Dive, C. (eds) Apoptosis and Cancer Chemotherapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-720-8_14

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  • DOI: https://doi.org/10.1007/978-1-59259-720-8_14

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-165-3

  • Online ISBN: 978-1-59259-720-8

  • eBook Packages: Springer Book Archive

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