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Insulin Resistance in Smokers and Other Long-Term Users of Nicotine

  • Chapter
Insulin Resistance

Part of the book series: Contemporary Endocrinology ((COE,volume 12))

Abstract

Smoking has long been considered a major health hazard, leading to both malignant disorders and cardiovascular disease (CVD). However, smoke contains many potentially harmful substances and it is currently unclear which agents can play a major role. Recent developments have implicated smoking as an important environmental factor in eliciting insulin resistance and the insulin resistance syndrome (IRS). IRS is the clustering of several important risk factors for CVD where insulin resistance appears to play a pivotal role. These risk factors include dyslipidemia, dysfibrinolysis and impaired glucose tolerance including Type 2 diabetes mellitus.

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References

  1. Collishaw NE, Lopez AD. The tobacco epidemic: A global public health emergency. In: Geneva, Switzerland: WHO. Available at online URL: http://www.who.ch/programmes/psa/toh/alert.1996 pp. 1–28.

  2. McGinnis JM, Foege WH. Actual causes of death in the United States. JAMA 1993; 270: 2207–2012.

    PubMed  CAS  Google Scholar 

  3. Doll R, Peto R, Wheatley K, Gray R, Sutherland I. Mortality in relation to smoking: 40 years’ observations on male British doctors. BMJ 1994; 309: 901–911.

    PubMed  CAS  Google Scholar 

  4. Grassi G, Seravalle G, Calhoun DA, Bolla GB, Giannattasio C, Marabini M, et al. Mechanisms responsible for sympathetic activation by cigarette smoking in humans. Circulation 1994; 90: 248–253.

    PubMed  CAS  Google Scholar 

  5. Green MS, Jucha E, Luz Y. Blood pressure in smokers and nonsmokers: Epidemiologic findings. Am Heart J 1986; 111: 932–939.

    PubMed  CAS  Google Scholar 

  6. Bolinder GM, Ahlborg BO, Lindell JH. Use of smokeless tobacco: blood pressure elevation and other health hazards found in a large-scale population survey. J Intern Med 1992; 232: 327–334.

    PubMed  CAS  Google Scholar 

  7. Craig WY, Palomaki GE, Haddow JE. Cigarette smoking and serum lipid and lipoprotein concentrations: An analysis of published data. BMJ 1989; 298: 784–788.

    PubMed  CAS  Google Scholar 

  8. Kannel WB, D’ Agostino RB, Belanger AJ. Fibrinogen, cigarette smoking and risk of cardiovascular disease: Insights from the Framingham study. Am Heart J 1987; 113: 1006–1010.

    PubMed  CAS  Google Scholar 

  9. Ernst E, Resch KL. Fibrinogen as a cardiovascular risk factor: A meta-analysis and review of the literature. Ann Intern Med 1993; 118: 956–963.

    PubMed  CAS  Google Scholar 

  10. Kool MJ, Hoeks AP, Struijker BHA, Reneman RS, Van BLM. Short-and long-term effects of smoking on arterial wall properties in habitual smokers. J Am Coll Cardiol 1993; 22: 1881–1886.

    PubMed  CAS  Google Scholar 

  11. Crouse J, Toole J, McKinney W, Dignan M Risk factors for extracranial carotid artery atherosclerosis. Stroke 1987; 18: 990–996.

    PubMed  CAS  Google Scholar 

  12. Dempsey RJ, Moore RW. Amount of smoking independently predicts carotid artery atherosclerosis severity. Stroke 1992; 23: 693–696.

    PubMed  CAS  Google Scholar 

  13. Lassila HC, Tyrrell KS, Matthews KA, Wolfson SK, Kuller LH. Prevalence and determinants of carotid atherosclerosis in healthy postmenopausal women. Stroke 1997; 28: 513–517.

    PubMed  CAS  Google Scholar 

  14. Lissner L, Bengtsson C, Lapidus L, Björkelund C. Smoking initiation and cessation in relation to body fat distribution based on data from a study of Swedish women. Am J Public Health, 82: 273–275.

    Google Scholar 

  15. Shimokata H, Muller DC, Andres R. (1989). Studies in the distribution of fat: Effects of cigarette smoking. JAMA 1992; 261: 1169–1173.

    Google Scholar 

  16. Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjöström L. Distribution of adipose tissue and risk of cardiovascular disease and death: A 12 year follow up of participants in the population study of women in Gothenburg, Sweden. BMJ 1984; 289: 1257–1261.

    PubMed  CAS  Google Scholar 

  17. Troisi RJ, Heinold JW, Vokonas PS, Weiss ST. Cigarette smoking, dietary intake and physical activity: Effects on body fat distribution-the Normative Aging Study. Am J Clin Nutr 1991; 53: 1104–1111.

    PubMed  CAS  Google Scholar 

  18. Zavaroni I, Bonini L, Gasparini P, Dall’Aglio E, Passeri M, Reaven GM. Cigarette smokers are relatively glucose intolerant, hyperinsulinemic and dyslipidemic. Am J Cardiol 1994; 73: 904–905.

    PubMed  CAS  Google Scholar 

  19. Eliasson M, Lundblad D, Hägg E. Cardiovascular risk factors in young snuff-users and cigarette smokers. J Intern Med 1991; 230: 17–22.

    PubMed  CAS  Google Scholar 

  20. Rönnemaa T, Rönnemaa EM, Puukka P, Pyörälä K, Laakso M. Smoking is independently associated with high plasma insulin levels in nondiabetic men. Diabetes Care 1996; 19: 1229–1132.

    PubMed  Google Scholar 

  21. Frati AC, Iniestra F, Raul Ariza C. Acute effect of cigarette smoking on glucose tolerance and other cardiovascular risk factors. Diabetes Care 1996; 19: 112–118.

    PubMed  CAS  Google Scholar 

  22. Attvall S, Fowelin J, Lager I, von Schenck H, Smith U. Smoking induces insulin resistance-A potential link with the insulin resistance syndrome. J Intern Med 1993; 233: 327–332.

    PubMed  CAS  Google Scholar 

  23. Facchini FS, Hollenbeck CB, Jeppesen J, Chen Y-DI, Reaven GM. Insulin resistance and cigarette smoking. Lancet 1992; 339: 1128–1130.

    PubMed  CAS  Google Scholar 

  24. Epifano L, Di Vincenzo A, Fanelli C, Porcellati F, Perriello G, De Feo P, et al. Effect of cigarette smoking and of a transdermal nicotine delivery system on glucoregulation in type 2 diabetes mellitus. Eur J Clin Pharmacol 1992; 43: 257–263.

    PubMed  CAS  Google Scholar 

  25. Eliasson B, Mero N, Taskinen M-R, Smith U. The insulin resistance syndrome and postprandial lipid intolerance in smokers. Atherosclerosis 1997; 129: 79–88.

    PubMed  CAS  Google Scholar 

  26. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214 - E223.

    PubMed  CAS  Google Scholar 

  27. Eliasson B, Attvall S, Taskinen MR, Smith U. The insulin resistance syndrome in smokers is related to smoking habits. Arterioscl Thromb 1994; 14: 1946–1950.

    PubMed  CAS  Google Scholar 

  28. Godsland IF, Wynn V, Walton C, Stevenson JC. Insulin resistance and cigarette smoking:letter. Lancet 1992; 339: 1619–1620.

    PubMed  CAS  Google Scholar 

  29. Godsland IF, Walton C, Felton C, Proudler A, Patel A, Wynn V. Insulin resistance, secretion and metabolism in users of oral contraceptives. J Clin Endocrinol Metab 1992; 74: 64–70.

    PubMed  CAS  Google Scholar 

  30. Targher G, Alberiche M, Zenere MB, Bonadonna RC, Muggeo M, Bonora E. Cigarette smoking and insulin resistance in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1997; 82: 3619–3624.

    PubMed  CAS  Google Scholar 

  31. Helve E, Yki-Järvinen H, Koivisto VA. Smoking and insulin sensitivity in type I diabetic patients. Metabolism 1986; 35: 874–877.

    PubMed  CAS  Google Scholar 

  32. Nilsson PM, Lind L, Pollare T, Berne C, Lithell HO. Increased levels of Hemoglobin Alc, but not impaired insulin sensitivity, found in hypertensive and normotensive smokers. Metabolism 1995; 44: 557–561.

    PubMed  CAS  Google Scholar 

  33. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independant of obesity. Metabolism 1990; 39: 167–174.

    PubMed  CAS  Google Scholar 

  34. Andersson K, Eneroth P, Amer P. Changes in circulating lipid and carbohydrate metabolites following systemic nicotine treatment in healthy men. Int J Obesity 1993; 17: 675–680.

    CAS  Google Scholar 

  35. Cryer PE, Haymond MW, Santiago JV, Shah SD. Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med 1976; 295: 573–577.

    PubMed  CAS  Google Scholar 

  36. Hellerstein MK, Benowitz NL, Neese RA, Schwartz J-M, Hoh R, Jacob P, III, et al. Effects of cigarette smoking and its cessation on lipid metabolism and energy expenditure in heavy smokers. J Clin Invest 1994; 93: 265–272.

    PubMed  CAS  Google Scholar 

  37. Kershbaum A, Bellet S, Dickstein ER, Feinberg LJ. Effect of cigarette smoking and nicotine on serum fatty acids. Based on a study in the human subject and the experimental animal Circ Res 1961; 9: 631–638.

    CAS  Google Scholar 

  38. Kershbaum A, Khorsandian R, Caplan RF, Bellet S, Feinberg LJ. The role of catecholamines in the free fatty acid respons to cigarette smoking. Circulation 1963; 28: 52–57.

    PubMed  CAS  Google Scholar 

  39. Eliasson B, Taskinen M-R, Smith U. Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance. Circulation 1996; 94: 878–881.

    PubMed  CAS  Google Scholar 

  40. Brunzell JD, Goldberg AP, Schwartz RS. Cigarette smoking and adipose tissue lipoprotein lipase. Int J Obesity 1980; 4: 101–103.

    CAS  Google Scholar 

  41. Carney RM, Goldberg AP. Weight gain after cessation of cigarette smoking. A possible role for adipose-tissue lipoprotein lipase. N Engl J Med 1984; 310: 614–616.

    PubMed  CAS  Google Scholar 

  42. Chajek-Shaul, Berry EM, Ziv E, Friedman G, Stein O, Sherer G, et al. Smoking depresses adipose lipoprotein lipase response to oral glucose. Eur J Clin Invest 1990; 20: 299–304.

    Google Scholar 

  43. Pollare T, Vessby B, Lithell H. Lipoprotein lipase activity in skeletal muscle is related to insulin sensitivity. Arterioscl Thromb 1991; 11: 1192–1203.

    PubMed  CAS  Google Scholar 

  44. Jeppesen J, Hollenbeck CB, Zhou M-Y, Coulston AM, Jones C, Chen Y-DI, et al. Relation between insulin resistance, hyperinsulinemia, postheparin plasma lipoprotein lipase activity, and postprandial lipemia Arterioscl Thromb Vasc Biol 1995; 15: 320–324.

    CAS  Google Scholar 

  45. Bielicki JK, McCall MR, van den Berg JJM, Kuypers FA, Forte TM. Copper and gas-phase cigarette smoke inhibit plasma lecithin:cholesterol acyltransferase activity by different mechanisms. J Lipid Res 1995; 36: 322–331.

    PubMed  CAS  Google Scholar 

  46. Dullaart RP, Groener JE, Dikkeschei BD, Erkelens DW, Doorenbos H. Elevated cholesteryl ester transfer protein activity in IDDM men who smoke. Possible factor for unfavorable lipoprotein profile. Diabetes Care 1991; 14: 338–341.

    PubMed  CAS  Google Scholar 

  47. Dullaart RP, Hoogenberg K, Dikkeschei BD, van Tol A. Higher plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarette-smoking men. Arterioscl Thromb 1994; 14: 1581–1585.

    PubMed  CAS  Google Scholar 

  48. Hannuksela ML, Liinamaa MJ, Kesäniemi YA, Savolainen MJ. Relation of polymorphisms in the cholesteryl ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkers. Atherosclerosis 1994; 110: 35–44.

    PubMed  CAS  Google Scholar 

  49. McCall MR, van den Berg JJ, Kuypers FA, Tribble DL, Krauss RM, Knoff LJ, et al. Modification of LCAT activity and HDL structure. New links between cigarette smoke and coronary heart disease risk. Arterioscl Thromb 1994; 14: 248–253.

    PubMed  CAS  Google Scholar 

  50. Axelsen M, Eliasson B, Joheim T, Lenner R, Taskinen M-R, Smith U. Lipid intolerance in smokers. J Intern Med 1995; 237: 449–455.

    PubMed  CAS  Google Scholar 

  51. Zilversmit DB. Atherogenesis: A postprandial phenomenon. Circulation 1979; 60: 473–485.

    CAS  Google Scholar 

  52. Karpe F. Alimentary lipemia and coronary atherosclerosis. Stockholm, Sweden: King Gustaf V research institute and Karolinska institute, University of Stockholm; 1992.

    Google Scholar 

  53. Patsch W, Sharrett AR, Sorlie PD, Davis CE, Brown SA. The relation of high density lipoprotein cholesterol and its subfractions to apolipoprotein A-I and fasting triglycerides: the role of environmental factors. The Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 1992; 136: 546–557.

    PubMed  CAS  Google Scholar 

  54. Chen Y-DI, Swami S, Skowronski R, Coulston A, Reaven G. Differences in postprandial lipemia between patients with normal glucose tolerance and noninsulin dependent diabetes mellitus. J Clin Endocrinol Metab 1993; 76: 172–177.

    PubMed  CAS  Google Scholar 

  55. Syvänne M, Hilden H, Taskinen M-R. Abnormal metabolism of postprandial lipoproteins in patients with non-insulin-dependent diabetes mellitus is not related to coronary artery disease. J Lipid Res 1994; 35: 15–26.

    PubMed  Google Scholar 

  56. Patsch JR, Miesenböck G, Hopferwieser T, Mühlberger V, Knapp E, Dunn JK, et al. Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscl Thromb 1992; 12: 1336–1345.

    PubMed  CAS  Google Scholar 

  57. Mero N, Syvänne M, Eliasson B, Smith U, Taskinen M-R. Postprandial elevation of Apo B-48-containing triglyceride rich particles and retinyl palmitate in normolipemic men who smoke. Arterioscl Thromb Vasc Biol 1997; 17: 2096–2102.

    PubMed  CAS  Google Scholar 

  58. Lewis GF, Uffelman KD, Szeto LW, Steiner G. Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes 1993; 42: 833–842.

    PubMed  CAS  Google Scholar 

  59. Malmström R, Packard CJ, Caslake M, Bedford D, Stewart P, Shepard J, et al. Defective suppression of VLDL1 Apo B production by insulin is an inherent feature of dyslipidemia in NIDDM. Diabetologia 1996;39(Suppl 1): A65: 238.

    Google Scholar 

  60. Naoumova RP, Cummings MH, Watts GF, Rendell NB, Taylor GW, Sönksen PH, et al. Acute hyperinsulinaemia decreases cholesterol synthesis less in subjects with non-insulin-dependent diabetes mellitus than in non-diabetic subjects. Eur J Clin Invest 1996; 26: 332–340.

    PubMed  CAS  Google Scholar 

  61. Silagy C, Mant D, Fowler G, Lodge M. Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation. Lancet 1994; 343: 139–142.

    PubMed  CAS  Google Scholar 

  62. Bolinder G, Alfredsson L, Englund A, de Faire U. Smokeless tobacco use and increased cardiovascular mortality among Swedish construction workers. Am J Public Health 1994; 84: 399–404.

    PubMed  CAS  Google Scholar 

  63. Benowitz NL. Pharmacologic aspects of cigarette smoking and nicotine addiction. N Engl J Med 1988; 319: 1318–1330.

    PubMed  CAS  Google Scholar 

  64. Svensson CK. Clinical pharmacokinetics of nicotine. Clin Pharmacokinetics 1987; 12: 30–40.

    CAS  Google Scholar 

  65. Kawachi I, Colditz GA, Stampfer MJ, Willett WC, Manson JE, Rosner B, et al. Smoking cessation in relation to total mortality rates in women. A prospective cohort study. Ann Intern Med 1993; 119: 992–1000.

    PubMed  CAS  Google Scholar 

  66. Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC. Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men. BMJ 1995; 310: 555–559.

    PubMed  CAS  Google Scholar 

  67. Rimm EB, Manson JE, Stampfer MJ, Colditz GA, Willett WC, Rosner B, et al. Cigarette smoking and the risk of diabetes in women. Am J Public Health 1993; 83: 211–214.

    PubMed  CAS  Google Scholar 

  68. Brischetto CS, Connor WE, Connor SL, Matarazzo JD. Plasma lipid and lipoprotein profiles of cigarette smokers from randomly selected families: enhancement of hyperlipidemia and depression of high-density lipoprotein. Am J Cardiol 1983; 52: 675–680.

    PubMed  CAS  Google Scholar 

  69. Nilsson P, Lundgren H, Söderström M, Fagerström K-O, Nilsson-Ehle P. Effects of smoking cessation on insulin and cardiovascular risk factors-A controlled study of 4 months duration. J Intern Med 1996; 240: 189–194.

    PubMed  CAS  Google Scholar 

  70. Stubbe I, Eskilsson J, Nilsson-Ehle P. High-density lipoprotein concentrations increase after stopping smoking. BMJ 1982; 284: 1511–1513.

    PubMed  CAS  Google Scholar 

  71. Quensel M, Söderström A, Agardh CD, Nilsson-Ehle P. High density lipoprotein concentrations after cessation of smoking: The importance of alterations in diet. Atherosclerosis 1989; 75: 189–193.

    CAS  Google Scholar 

  72. Terres W, Becker P, Rosenberg A. Changes in cardiovascular risk profile during the cessation of smoking. Am J Med 1994; 97: 242–249.

    PubMed  CAS  Google Scholar 

  73. Ernst E, Matrai A. Abstention from chronic cigarette smoking normalizes blood rheology. Atherosclerosis 1987; 64: 75–77.

    PubMed  CAS  Google Scholar 

  74. Seltzer CC. Effect of smoking on blood pressure. Am Heart J 1974; 87: 558–564.

    PubMed  CAS  Google Scholar 

  75. Eliasson B, Attvall S, Taskinen M-R, Smith U. Smoking cessation improves insulin sensitivity in healthy middle-aged men. Eur J Clin Invest 1997; 27: 450–456.

    PubMed  CAS  Google Scholar 

  76. Williamson DF, Madans J, Anda RF, Kleinman JC, Giovino GA, Byers T. Smoking cessation and severity of weight gain in a national cohort. N Engl J Med 1991; 324: 739–745.

    PubMed  CAS  Google Scholar 

  77. Dallosso HM, James WPT. The role of smoking in the regulation of energy balance. Int J Obesity 1984; 8: 365–375.

    CAS  Google Scholar 

  78. Moffatt RI, Owens SG. Cessation from cigarette smoking: changes in body weight, body composition, resting metabolism and energy consumption. Metabolism 1991; 40: 465–470.

    PubMed  CAS  Google Scholar 

  79. Gerace TA, Hollis J, Ockene JK, Svendsen K. Smoking cessation and change in diastolic blood pressure, body weight, and plasma lipids. Prey Med 1991; 20: 602–620.

    CAS  Google Scholar 

  80. Hall SM, McGee R, Tunstall C, Duffy J, Benowitz N. Changes in food intake and activity after quitting smoking. J Consult Clin Psychol 1989; 57: 81–86.

    PubMed  CAS  Google Scholar 

  81. Rodin J. Weight change following smoking cessation: The role of food intake and exercise. Addict Behav 1987; 12: 303–317.

    PubMed  CAS  Google Scholar 

  82. Hofstetter A, Schutz Y, Jéquier E, Wahren J. Increased 24-hour energy expenditure in cigarette smokers. N Engl J Med 1986; 314: 79–82.

    PubMed  CAS  Google Scholar 

  83. Dotevall A, Rângemark C, Eriksson E, Kutti J, Wadenvik H, Wennmalm A. Cigarette smoking increases thromboxane A2 formation without affecting platelet survival in healthy young females. Thromb Haemost 1992; 68: 583–588.

    PubMed  CAS  Google Scholar 

  84. Blann AD, McCollum CN. Adverse influence of cigarette smoking on the endothelium. Thromb Hemost 1993; 70: 707–711.

    CAS  Google Scholar 

  85. Haire WD, Goldsmith JC, Rasmussen J. Abnormal fibrinolysis in healthy male cigarette smokers: Role of plasminogen activator inhibitors. Am J Hematol 1989; 31: 36–40.

    PubMed  CAS  Google Scholar 

  86. Smith U, Attvall S, Eriksson J, Fowelin J, Lönnroth P, Wesslau C. The insulin-antagonistic effect of the counterregulatory hormones-Clinical and mechanistic aspects. In: Östenson CG, Efendic S, Vranic M, eds. New concepts in the pathogenesis of NIDDM. Plenum, New York, 1992, pp. 169–180.

    Google Scholar 

  87. Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994; 93: 2438–2446.

    PubMed  CAS  Google Scholar 

  88. Feskens EJM, Kromhout D. Cardiovascular risk factors and the 25-year incidence of diabetes mellitus in middle-aged men. The Zutphen study. Am J Epidemiol 1989; 130: 1101–1108.

    PubMed  CAS  Google Scholar 

  89. Mühlhauser I. Cigarette smoking and diabetes: An update. Diabetic Med 1994; 11: 336–343.

    Google Scholar 

  90. Rosenthal M, Haskell WL, Solomon R, Widstrom A, Reaven GM. Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans. Diabetes 1983; 32: 408–411.

    PubMed  CAS  Google Scholar 

  91. Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995; 75: 473–486.

    PubMed  CAS  Google Scholar 

  92. Blair SN, Kampert JB, Kohl HW, III, Barlow CE, Macera CA, Paffenberger RS, et al. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 1996; 276: 205–210.

    PubMed  CAS  Google Scholar 

  93. Margetts BM, Jackson AA. Interactions between people’s diet and their smoking habits: The dietary and nutritional survey of British adults. BMJ 1993; 307: 1381–1384.

    PubMed  CAS  Google Scholar 

  94. Nuttens MC, Romon M, Ruidavets JB, Arveiler D, Ducimetiere P, Lecerf JM, et al. Relationship between smoking and diet: The MONICA-France project. J Intern Med 1992; 231: 349–356.

    PubMed  CAS  Google Scholar 

  95. Feskens EJM, Virtanen SM, Räsänen L, Tuomilehto J, Stengârd J, Pekkanen J, et al. Dietary factors determining diabetes and impaired glucose tolerance. Diabetes Care 1995; 18: 1104–1112.

    PubMed  CAS  Google Scholar 

  96. Storlien LH, Baur LA, Kriketos AD, Pan DA, Cooney GJ, Jenkins AB, et al. Dietary fats and insulin action. Diabetologia 1996; 39: 621–631.

    PubMed  CAS  Google Scholar 

  97. Willett WC. Diet and health: what should we eat? Science 1994; 264: 532–537.

    PubMed  CAS  Google Scholar 

  98. Doll R, Peto R, Hall E, Wheatley K, Gary R. Mortality in relation to consumption of alcohol: 13 years’ observations on male British doctors. BMJ 1994; 309: 911–918.

    PubMed  CAS  Google Scholar 

  99. Fuchs CS, Stampfer MJ, Colditz GA, Giovannucci EL, Manson JE, Kawachi I, et al. Alcohol consumption and mortality among women. N Engl J Med 1995; 332: 1245–1250.

    PubMed  CAS  Google Scholar 

  100. Gaziano JM, Buring JE, Breslow JL, Goldhaber SZ, Rosner B, VanDenburgh M, et al. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions and decreased risk of myocardial infarction. N Engl J Med 1993; 329: 1829–1834.

    PubMed  CAS  Google Scholar 

  101. Facchini F, Chen Y-DI, Reaven GM. Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care 1994; 17: 115–119.

    PubMed  CAS  Google Scholar 

  102. Assmann G, Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Am J Cardiol 1992; 70: 733–737.

    PubMed  CAS  Google Scholar 

  103. Després J-P, Lamarche B, Mauriège P, Cantin B, Dagenais GR, Moorjani S, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952–957.

    PubMed  Google Scholar 

  104. Katz RJ, R. E R, Cohen RM, Eisenhower E, Verme D. Are insulin and proinsulin independent risk markers for premature coronary artery disease? Diabetes 1996; 45: 736–741.

    CAS  Google Scholar 

  105. Salomaa V, Stinson V, Kark JD, Folsom AR, Davis CE, Wu KK. Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Circulation 1995; 91: 284–290.

    PubMed  Google Scholar 

  106. Wilson PWF. High-density lipoprotein, low-density lipoprotein and coronary artery disease. Am J Cardiol 1990; 66: 7A - 10A.

    PubMed  CAS  Google Scholar 

  107. Rosengren A, Wilhelmsen L, Wedel H. Coronary heart disease, cancer and mortality in male middle-aged smokers. J Intern Med 1992; 231: 357–362.

    PubMed  CAS  Google Scholar 

  108. Slone D, Shapiro S, Rosenberg L, Kaufman DW, Hartz SC, Rossi AC, et al. Relation of cigarette smoking to myocardial infarction in young women. N Engl J Med 1978; 298: 1273–1276.

    PubMed  CAS  Google Scholar 

  109. Tenkanen L, Pietila K, Manninen V, Manttari M. The triglyceride issue revisited. Findings from the Helsinki Heart Study. Arch Int Med 1994; 154: 2714–2720.

    CAS  Google Scholar 

  110. VanItallie TB. Prevalence of obesity. Endocrinol Metab Clin North Am 1996; 25: 887–905.

    PubMed  CAS  Google Scholar 

  111. Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and the weight gain as risk factors for clinical diabetes in men. Diabetes Care 1994; 17: 961–969.

    PubMed  CAS  Google Scholar 

  112. Kawakami N, Takatsuka N, Shimizu H, Ishibashi H. Effects of smoking on the incidence of noninsulin-dependent diabetes mellitus. Replication and extension in a Japanese cohort of male employees. Am J Epidemiol 1997; 145: 103–109.

    PubMed  CAS  Google Scholar 

  113. Perry IJ, Wannamethee SG, Walker MK, Thomson AG, Whincup PH, Shaper AG. Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men. BMJ 1995; 310: 560–564.

    PubMed  CAS  Google Scholar 

  114. Bott U, Jörgens V, Grüsser M, Bender R, Mühlhauser I, Berger M. Predictors of glycemic control in type 1 diabetic patients after participation in an intensfied treatment and teaching programme. Diabetic Med 1994; 11: 362–371.

    PubMed  CAS  Google Scholar 

  115. Lundman BM, Asplund K, Norberg A. Smoking and metabolic control in patients with insulin-dependent diabetes mellitus. J Intern Med 1990; 227: 101–106.

    PubMed  CAS  Google Scholar 

  116. Roth GM, McDonald JB, Sheard C. The effect of smoking cigarettes and the intravenous administration of nicotine on the electrocardiogram, basal metabolic rate, cutaneous temperature, blood pressure and pulse rate of normal persons. JAMA 1944; 125: 761–767.

    CAS  Google Scholar 

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Authors
  1. Björn Eliasson MD
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  2. Ulf Smith MD
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Editors and Affiliations

  1. Shaman Pharmaceuticals, Inc., South San Francisco, CA, USA

    Gerald M. Reaven MD

  2. Stanford University School of Medicine, Stanford, CA, USA

    Gerald M. Reaven MD

  3. Stanford University School of Medicine, Stanford, CA, USA

    Ami Laws MD

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Eliasson, B., Smith, U. (1999). Insulin Resistance in Smokers and Other Long-Term Users of Nicotine. In: Reaven, G.M., Laws, A. (eds) Insulin Resistance. Contemporary Endocrinology, vol 12. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-716-1_7

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  • DOI: https://doi.org/10.1007/978-1-59259-716-1_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-086-1

  • Online ISBN: 978-1-59259-716-1

  • eBook Packages: Springer Book Archive

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