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Diabetes in the Elderly

  • Chapter
Endocrinology of Aging

Part of the book series: Contemporary Endocrinology ((COE,volume 20))

Abstract

In the past few years, a number of epidemiologic studies have evaluated the incidence and prevalence of type 2 diabetes in the aged. Although these studies have used differing diagnostic criteria, they have consistently found an increased prevalence of diabetes in the elderly. The most recent data comes from the Health and Nutrition Examination Survey (HANES) III (1; Fig. 1). The prevalence of diabetes in patients over the age of 75 yr in the United States is approx 20%, and at least half of older people are unaware they have the disease (2). Although the prevalence is approx 20% in older Caucasians, it is much higher in Blacks, Hispanics, Native Indians, Micronesians, Scandinavians, Japanese, and other ethnic groups. Clearly, we are facing an epidemic of type 2 diabetes in the elderly in the next century.

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References

  1. Harris MI, Flegal KM, Cowie CC, et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. Diabetes Care 1998;21:518–524.

    Article  PubMed  CAS  Google Scholar 

  2. Harris MI. Undiagnosed NIDDM: clinical and public health issues. Diabetes Care 1993;16:642–652.

    PubMed  CAS  Google Scholar 

  3. Kahn CR. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994;43:1066–1984.

    Article  PubMed  CAS  Google Scholar 

  4. Harris MI. Epidemiology of diabetes among the elderly in the United States. Clin Geriatr Med 1990;6: 703–719.

    PubMed  CAS  Google Scholar 

  5. Skarfors ET, Selinus KI, Lithell HO. Risk factors for developing non-insulin-dependent diabetes. A 10-year follow-up of men in Uppsala. Br Med J 1991;303:755–760.

    Article  CAS  Google Scholar 

  6. Vaag A, Henriksen JE, Madsbad S, Holm N., Beck-Nielsen H. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:690–698.

    Article  PubMed  CAS  Google Scholar 

  7. Jackson RA. Mechanisms of age-related glucose intolerance. Diabetes Care 1990; 13(Suppl 2):9–19.

    Google Scholar 

  8. Tibblin G, Adlerberth A, Lindstedt GB, Bjbrntorp P. The pituitary-gonadal axis and health in elderly men. Diabetes 1996;45:1605–1609.

    Article  PubMed  CAS  Google Scholar 

  9. Goodman-Gruen D, Barrett-Connor E. Sex hormone-binding globulin and glucose tolerance in post-menopausal women. The Rancho Bernardo Study. Diabetes Care 1997;20:645–649.

    Article  PubMed  CAS  Google Scholar 

  10. Feskens EJM, Bowles CH, Kromhout D. Carbohydrate intake and body mass index relation to the risk of glucose in tolerance in an elderly population. Am J Clin Nutr 1991;54:136–140.

    PubMed  CAS  Google Scholar 

  11. Feskens EJM, Virtanen SM, Rasanen L, Tuomilehto J, Stengard J, Pekkanen J, Nissinen A, Kromhout D. Dietary factors determining diabetes and impaired glucose tolerance. Diabetes Care 1995; 18: 1104–1111.

    Article  PubMed  CAS  Google Scholar 

  12. Marshall J A, Weiss NS, Hamman RF. The role of dietary fiber in the etiology of non-insulin-dependent diabetes mellitus. The San Luis Valley diabetes study. Ann Epidemiol 1993;3:18–26.

    Article  PubMed  CAS  Google Scholar 

  13. Salmeron J, Asherio A, Rimm EB, Colditz GA, Spiegelman D, Jenkins DJ, et al. Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care 1997;20:545–550.

    Article  PubMed  CAS  Google Scholar 

  14. Lipton RB, Liao Y, Cao G, Cooper RS, McGee D. Determinants of incident non-insulin-dependent diabetes mellitus among blacks and whites in a national sample. The NHANES I Epidemiologic follow-up study. Am J Epidemol 1993;138:826–964.

    CAS  Google Scholar 

  15. Cassano PA, Rosner B, Vokonas PS. Obesity and body fat distribution in relation to the incidence of non-insulin-dependent diabetes mellitus. Am J Epidemol 1992;136:1474–1486.

    CAS  Google Scholar 

  16. Travia D, Bonora E, Cacciatori V, Zenere M, Tosi F, Branzil P, et al. Study of some putative pathogenic factors of diabetes mellitus in the elderly. Arch Gerontol Geriatr 1991;2(Suppl 2):219–222.

    Google Scholar 

  17. Morris RD, Rimm AA. Association of waist to hip ratio and family history with the prevalence of NIDDM among 25,272 adult, white females. Am J Public Health 1991;81:507–509.

    Article  PubMed  CAS  Google Scholar 

  18. Manson JE, Nathan DM, Krolewski AS, Stampter MJ, Willett HWC, Hennekens CH. A prospective study of exercise and incidence of diabetes among US male physicians. J Am Med Assoc 1992;268: 63–67.

    Article  CAS  Google Scholar 

  19. Mykkanen L, Kuusisto J, Pyörälä K, Laakso M. Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects. Diabetologia 1993;36:553–559.

    Article  PubMed  CAS  Google Scholar 

  20. Helmrich SP, Ragland DR, Leung RW, Paffenburger RS. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 1991;325:147–195.

    Article  PubMed  CAS  Google Scholar 

  21. Edelstein SL, Knowler WC, Bain RP, Andres R, Barrett-Connor EL, Dowse GK, et al. Predictors of progression from impaired glucose tolerance to NIDDM. Diabetes 1997;46:701–710.

    Article  PubMed  CAS  Google Scholar 

  22. Gurwitz J, Field TS, Glynn RJ, Manson JE, Avorn J, Taylor JO, Hennekens CH. Risk factors for NIDDM requiring treatment in the elderly. J Am Geriatr Soc 1994;42:1235–1240.

    PubMed  CAS  Google Scholar 

  23. Mooy JM, Grootenhuis PA, de Vries H, Valkenburg HA, Bouter LM, Kostense PJ, Heine RJ. Preva-lence and determinants of glucose intolerance in a Dutch Caucasian population. Diabetes Care 1995; 18: 1270–1273.

    Article  PubMed  CAS  Google Scholar 

  24. Stolk RP, Pols HA, Lamberts SWJ, de Jong PTVM, Hofman A, Grobbee DE. Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population. Am J Epidemiol 1997; 145: 24–32.

    Article  PubMed  CAS  Google Scholar 

  25. Pandit MK, Burke J, Gustafson AB, Minocha A, and Peiris AN. Drug induced disorders of glucose intolerance. Ann Int Med 1993;118:529–539.

    PubMed  CAS  Google Scholar 

  26. DeFronzo RA. Lilly Lecture 1987. The triumvirate: b-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988;37:667–687.

    PubMed  CAS  Google Scholar 

  27. Meneilly GS, Hards L, Tessier D, Elliott T, Tildesley H. NIDDM in the elderly. Diabetes Care 1996; 19:1320–1375.

    Article  PubMed  CAS  Google Scholar 

  28. Arner P, Pollare T, Lithell H. Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia 1991;4:483–487.

    Article  Google Scholar 

  29. Groop LC, Bottazzo GF, Doniach D. Islet cell antibodies identify latent type 1 diabetes in patients aged 35–75 years at diagnosis. Diabetes 1986;35:235–240.

    Google Scholar 

  30. Clauson P, Linnarsson R, Gottsater A, Sundkvist G, Grill V. Relationships between diabetes duration, metabolic control and β-cell function in a representative population of type 2 diabetic patients in Sweden. Diabetic Med 1994;11:794–801.

    Article  PubMed  CAS  Google Scholar 

  31. Tuomilehto-Wolf E, Tuamilehto J, Hitman GA, Nissinen A, Stengard J, Pekkanen S, et al. Genetic susceptibility to NIDDM and glucose tolerance are located in the HLNA region. Br Med J 1993;307: 155–159.

    Article  CAS  Google Scholar 

  32. Leslie RDG, Pozzilli P. Type 1 diabetes masquerading as type II diabetes. Diabetes Care 1994; 17: 1214–1219.

    Article  PubMed  CAS  Google Scholar 

  33. Gleichmann H, Zorcher B, Greulich B, Gries FA, Henrichs HR, Bertrams J, Kolb H. Correlation of islet cell antibodies and HLA-DR phenotypes with diabetes mellitus in adults. Diabetologia 1984;27:90–92.

    Article  PubMed  Google Scholar 

  34. Wroblewski M, Gottsater A, Lindgarde F, Fernlund P, Sundkvist G. Gender, antibodies and obesity in newly diagnosed diabetic patients aged 40–75 years. Diabetes Care 1988;21:250–255.

    Article  Google Scholar 

  35. Ruige JB, Batstra MR, Aanstoot H-J, Bouter LM, Bruining GJ, de Neeling JN, Heine RJ. Low preva-lence of antibodies to GAD65 in a 50- to 74-year-old general Dutch population. The Hoorn Study. Diabetes Care 1997;20:1108–1110.

    Article  PubMed  CAS  Google Scholar 

  36. Turner R, Stratton I, Horton V, Manley S, Zimmet P, Mackay IR, et al. UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. Lancet 1997;350:1288–1293.

    Article  PubMed  CAS  Google Scholar 

  37. Best JD, Kahn SE, Ader M, Watanabe RM, Ni TC, Bergman RN. Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care 1996;19:1018–1030.

    PubMed  CAS  Google Scholar 

  38. Forbes A, Elliott T, Tildesley H, Finegood D, Menielly GS. Alterations in non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes 1998;47:1915–1919.

    Article  PubMed  CAS  Google Scholar 

  39. McCarthy MI, Hitman GA, Hitchins M, Riikonen A, Stengard J, Nissinen A, et al. Glucokinase gene polymorphisms: a genetic marker for glucose intolerance in cohort of elderly Finnish men. Diabetic Med 1993;10:198–204.

    Google Scholar 

  40. Laakso M, Malkki M, Kekalainen P, Kuusisto J, Mykannen L, Deeb S. Glukokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance. Diabetes Care 1995; 18:398–400.

    Article  PubMed  CAS  Google Scholar 

  41. Obermajer-Kusser B, White MF, Pongratz DE, Su L, Ermel B, Muhlbacher C, et al. A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus. J Biol Chem 1989;264: 9497–9504.

    Google Scholar 

  42. Gambert SR. Atypical presentation of diabetes in the elderly. Clin Geriatr Med 1990;6:721–729.

    PubMed  CAS  Google Scholar 

  43. Morley JE, Kaiser FE. Unique aspects of diabetes mellitus in the elderly. Clin Geriatr Med 1990;6: 693–702.

    PubMed  CAS  Google Scholar 

  44. Tattersall RB. Diabetes in the elderly—a neglected area. Diabetologia 1984;27:167–173.

    PubMed  CAS  Google Scholar 

  45. James WD, Odom RB, Goette DKL Bullous eruption of diabetes mellitus. Arch Dermatol 1980; 116: 1191–1192.

    Article  PubMed  CAS  Google Scholar 

  46. Friedman NA, LeBan NB. Periarthrosis of the shoulder associated with diabetes mellitus. Am J Phys Med Rehab 1989;68:12–14.

    Article  CAS  Google Scholar 

  47. Neil MAW, Dawson JA, Baker JE. Risk of hypothermia in elderly patients with diabetes. Br Med J 1986;293:416–418.

    Article  CAS  Google Scholar 

  48. Ellenberg M. Diabetic neuropathic cachexia. Diabetes 1974;23:418–423.

    PubMed  CAS  Google Scholar 

  49. Pagano G, Bargero G, Bruno G. Prevalence and clinical features of known type 2 diabetes in the elderly: a population-based study. Diabetic Med 1991;11:475–478.

    Article  Google Scholar 

  50. Mooradian AD, Osterveil D, Petrasek D, Morley JE. Diabetes mellitus in elderly nursing home patients. J Am Geriatr Soc 1988;36:391–396.

    PubMed  CAS  Google Scholar 

  51. Sinclair AJ, Robert IM, Croxson SCM. Mortality in older people with diabetes mellitus. Diabet Med 1996;14:639–647.

    Article  Google Scholar 

  52. Muggeo M, Verlato G, Bonora E, Ciani F, Moghetti P, Eastman R, Crepaldi G, de Marco R. Long-term instability of fasting plasma glucose predicts mortality in elderly NIDDM patients: the Verona diabetes study. Diabetologia 1995;38:672–679.

    Article  PubMed  CAS  Google Scholar 

  53. Seeman TE, Charpentier PT, Berkman LF, Tinetti ME, Guralnik JM, Albert M, Blazer D, Rowe JW. Predicting changes in physical performance in a high-functioning elderly cohort: MacArthur studies of successful aging. J Gerontol 1994;49:M97-M108.

    PubMed  CAS  Google Scholar 

  54. Perkowski LC, Stroup-Benham CA, Markides KS, Lichtenstein MJ, Angel, RJ, Guralnik JM, Goodwin JS. Lower-extremity functioning in older Mexican Americans and its association with medical problems. J Am Geratr Soc 1998;46:411–418.

    CAS  Google Scholar 

  55. Woo J, Ho SC, Yu LM, Lau J, Yuen YK. Impact of chronic diseases on functional limitations in elderly Chinese aged 70 years and over: a cross-sectional and longitudinal surgey. J Geront 1988;53: M102-M106.

    Google Scholar 

  56. Connell CM. Psychosocial aspects of diabetes and older adulthood: reciprocal effects. Diabetes Educ 1991;17:364–371.

    Article  PubMed  CAS  Google Scholar 

  57. Petterson T, Lee P, Hollis S, Young B, Newton P, Dornan T. Well-being and treatment satisfaction in older people with diabetes. Diabetes Care 1998;21:930–935.

    Article  PubMed  CAS  Google Scholar 

  58. Damsgard EM, Froland A, Holm N. Use of hospital services by elderly patients with diabetes. Diabetic Med 1987;4:317–321.

    Article  Google Scholar 

  59. Damsgaard EM, Froland A, Holm N. Ambulatory medical care for elderly patients with diabetes: the Frederica study of diabetic and fasting hyperglycaemic patients aged 60–74 years. Diabetic Med 1987; 4:317–321.

    Article  PubMed  CAS  Google Scholar 

  60. Panser LA, Naessems JM, Nobrega FT, Palumbo PJ, Ballard DJ. Utilization trends and risk factors for hospitalization in diabetes mellitus. Mayo Clin Proc 1990;65:1171–1184.

    PubMed  CAS  Google Scholar 

  61. Rosenthal MJ, Fajardo M, Gilmore S, Morley J, Naliboff BD. Hospitalization and mortality of diabetes in older adults. Diabetes Care 1998;21:231–235.

    Article  PubMed  CAS  Google Scholar 

  62. Selby JV, Zhang D, Ray GT, Colby CJ. Excess costs of medical care for patients with diabetes in a managed care population. Diabetes Care 1997;20:1396–1402.

    Article  PubMed  CAS  Google Scholar 

  63. Gilmer TP, Manning WG, O’Connor PJ, Rush WA. The cost to health plans of poor glycerine control. Diabetes Care 1997;20:1847–1853.

    Article  PubMed  CAS  Google Scholar 

  64. Currie CJ, Morgan, CL, Peters JR. The epidemiology and cost of inpatient care for peripheral vascular disease, infection, neuropathy and ulceration in diabetes. Diabetes Care 1998;21:42–48.

    Article  PubMed  CAS  Google Scholar 

  65. Ray NF, Thamer M, Taylor T, Fehrenbach SN, Ratner R. Hospitalization and expenditures of the treatment of general medical conditions among the U.S. diabetic population in 1991. J Clin Endocrinol Metabol 1996;81:3671–3678.

    Article  CAS  Google Scholar 

  66. American Diabetes Association. Economic consequences of diabetes mellitus in the U.S. in 1997. Diabetes Care 1998;21:296–309.

    Article  Google Scholar 

  67. Krop JS, Powe NR, Weller WE, Shaffer TJ, Saudek CD, Anderson GF. Patterns of expenditures and use of services among older adults with diabetes. Diabetes Care 1998;21:747–752.

    Article  PubMed  CAS  Google Scholar 

  68. Morris AD, McAlpine R, Steinke D, Boyle DIR, Abdul-Rahim E, Boyle DI, Ebrahim AR, Vasudev N, et al. Diabetes and lower-limb amputations in the community. A retrospective cohort study. Dia-betes Care 1998;21:738–743.

    Article  CAS  Google Scholar 

  69. Greene DA. Acute and chronic complications of diabetes mellitus in older patients. Am J Med 1986; 80(Suppl 5A):39–53.

    Article  PubMed  CAS  Google Scholar 

  70. Nathan DM, Singer DE, Godine JE, Perlmuter LC. Non-insulin-dependent diabetes in older patients. Am J Med 1986;81:837–842.

    Article  PubMed  Google Scholar 

  71. Cohen DL, Neil HAW, Thorogood M, Mann JI. A population-based study of the incidence of com-plications associated with Type 2 diabetes in the elderly. Diabetic Med 1991;8:928–933.

    Article  PubMed  CAS  Google Scholar 

  72. Welborn TA, Wearne K. Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care 1979;2:154–160.

    Article  PubMed  CAS  Google Scholar 

  73. Ford ES, DeStefano F. Risk factors for mortality from all causes and from coronary heart disease among persons with diabetes. Am J Epidemiol 1991;133:1220–1230.

    PubMed  CAS  Google Scholar 

  74. Jarrett RJ, McCarthy P, Keen H. The Bedford survey: Ten-year mortality rates in newly diagnosed patients with diabetes, borderline patients with diabetes and normoglycaemic controls and risk indices for coronary heart disease in borderline patients with diabetes. Diabetologia 1982;22:79–84.

    PubMed  CAS  Google Scholar 

  75. Hiller R, Sperduto RD, Podgor MJ, Ferris FL III, Wilson PWF. Diabetic retinopathy and cardiovas-cular disease in type II diabetes. Am J Epidemiol 1988; 128:402–409.

    PubMed  CAS  Google Scholar 

  76. Mykkanen L, Laakso M, Penttila I, Pyörälä K. Asymptomatic hyperglycaemia and atherosclerotic vascular disease in the elderly. Diabetes Care 1992;15:1020–1030.

    Article  PubMed  CAS  Google Scholar 

  77. Donahue RP, Abbott RD, Reed DM, Yano K. Postchallenge glucose concentration and coronary heart disease in men of Japanese ancestry. Diabetes 1987;36:689–692.

    Article  PubMed  CAS  Google Scholar 

  78. Wingard DL, Barrett-Connor EL, Scheidt-Nave C, McPhillips JB. Prevalence of cardiovascular and renal complications in older adults with normal or impaired glucose tolerance in NIDDM. Diabetes Care 1993;16:1022–1025.

    Article  PubMed  CAS  Google Scholar 

  79. Naliboff BD, Rosenthal M. Effects of age on complications of adult onset diabetes. J Am Geriatr Soc 1989;37:838–842.

    PubMed  CAS  Google Scholar 

  80. Abbott RD, Donahue RP, MacMahon SW, Reed DM, Yano K. Diabetes and the risk of stroke. J Am Med Assoc 1987;257:949–956.

    Article  CAS  Google Scholar 

  81. Singer DE, Nathan DM, Anderson KM, Wilson PWF, Evans JC. Association of Hgb A1C with preva-lent cardiovascular disease in the original cohort of the Framingham heart study. Diabetes 1992;41: 202–208.

    Article  PubMed  CAS  Google Scholar 

  82. Davis TME, Stratton IM, Fox CJ, Holman RR, Turner R. U.K. prospective diabetes study 22. Diabetes Care 1997;20:1435–1441.

    Article  PubMed  CAS  Google Scholar 

  83. Sinclair AJ, Allard I, Bayer A. Observations of diabetes care in long-term institutional settings with measures of cognitive function and dependency. Diabetes Care 1997;20:778–784.

    Article  PubMed  CAS  Google Scholar 

  84. Klein R. Hyperglycemia and microvascular and macro vascular disease in diabetes. Diabetes Care 1995;18:258–268.

    Article  PubMed  CAS  Google Scholar 

  85. Vokonas PS, Kannel WB. Diabetes mellitus and coronary heart disease in the elderly. Clin Ger Med 1996;12:69–77.

    CAS  Google Scholar 

  86. Beks PHJ, MacKaay AJC, deVries H, de Neeling, JND, Bouter LM, Heine RJ. Carotid artery stenosis is related to blood glucose level in an elderly Caucasian population: the Hoorn study. Diabetologia 1997;40:290–198.

    Article  PubMed  CAS  Google Scholar 

  87. Kannel WB, McGee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study. Diabetes Care 1979;2:120–126.

    Article  PubMed  CAS  Google Scholar 

  88. Beks PJ, MacKaay AJC, deNeeling JND, deVries H, Bouter LM, Heine RJ. Peripheral arterial disease in relation to glycaemic level in an elderly Caucasian population: the Hoorn Study. Diabetologia 1995; 38:86–96.

    Article  PubMed  CAS  Google Scholar 

  89. Kuusisto J, Mykkänen L, Pyörälä K, Laakso M. Non-insulin-dependent diabetes and its metabolic control and important predictors of stroke in elderly subjects. Stroke 1994;25:1157–1164.

    Article  PubMed  CAS  Google Scholar 

  90. Kuusisto J, Mykkanen, Pyörälä, Laakso M. NIDDM and its metabolic control predict coronary heart disease in elderly subjects. Diabetes 1994;43:960–967.

    Article  PubMed  CAS  Google Scholar 

  91. Malmberg K. Prospective randomised study of intensive insulin treatment on long-term survival after acute myocardial infarction in patients with diabetes mellitus. Br Med J 1997;314:1512–1515.

    Article  CAS  Google Scholar 

  92. Naliboff BC, Gilmore SL, Rosenthal MJ. Acute autonomic responses to postural change, Valsalva maneuver, and paced breathing in older type II diabetic men. J Am Geriatr Soc 1993;41:648–653.

    PubMed  CAS  Google Scholar 

  93. Olivarius N de F, Andreasen AH, Keiding N, Mogensen CE. Epidemiology of renal involvement in newly-diagnosed middle-aged and elderly diabetic patients. Cross-sectional data from the population-based study “Diabetes Care in General Practice,” Denmark. Diabetologia 1993;22:115–121.

    Google Scholar 

  94. Ohno T, Kato N, Shimizu M, Ishii C, Ito S, Tomono S, et al. Effect of age on the development or progression of albuminuria in non-insulin-dependent diabetes mellitus (NIDDM) without hyperten-sion. Diabetes Res 1993;22:115–121.

    PubMed  CAS  Google Scholar 

  95. Chen MS, Kao CS, Chang CJ, Wu TJ, Fu CC, Chen CJ, et al. Prevalence and risk factors of diabetic retinopathy among noninsulin-dependent diabetic subjects. Am J Ophthal 1992;114:723–730.

    PubMed  CAS  Google Scholar 

  96. Humphrey LL, Ballard DJ. Renal complications in non-insulin-dependent diabetes mellitus. Clin Geriatr Med 1990;6:807–825.

    PubMed  CAS  Google Scholar 

  97. Walters DP, Gatling W, Mullee MA, Hill RD. The prevalence of diabetic distal sensory neuropathy in an English community. Diabetic Med 1992;9:349–353.

    Article  PubMed  CAS  Google Scholar 

  98. Schmidt RE, Plurad SB, Parvin CA, Roth KA. Effect of diabetes and aging on human sympathetic autonomic ganglia. Am J Path 1993;143:143–153.

    PubMed  CAS  Google Scholar 

  99. Schmitz A. Renal function changes in middle-aged and elderly Caucasian type 2 (non-insulin-dependent) diabetic patients—a review. Diabetologia 1993;36:985–992.

    Article  PubMed  CAS  Google Scholar 

  100. Comi G, Lozza L, Galardi G, Ghilardi, MF, Madaglini S, Canal N. Presence of carpal tunnel syndrome in diabetes: effect of age, sex, diabetes duration and polyneuropathy. Acta Diabetol 1985;22:259–262.

    Article  CAS  Google Scholar 

  101. Maser RE, Laudadio C, DeCherney GS. The effects of age and diabetes mellitus on nerve function. J Am Geriatr Soc 1993;41:143–153.

    Google Scholar 

  102. Wang CJ, Shen SY, Wu CC, Huang CH, Chiang CP. Penile blood flow in diabetic impotence. Urol Int 1993;50:209–212.

    Article  PubMed  CAS  Google Scholar 

  103. Masaoka S, Lev-Ran A, Hill LR, Vakil G, Hon EHG. Heart rate variability in diabetes; relationship to age and duration of the disease. Diabetes Care 1985;8:64–68.

    Article  PubMed  CAS  Google Scholar 

  104. Young MJ, Boulton AJM, Macleod AF, Williams DRR, Sonksen PH. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993;36:150–154.

    Article  PubMed  CAS  Google Scholar 

  105. Stolk RP, Vingerling JR, de Jong PTVM, Dielemans I, Hofman A, Lamberts, SWJ, et al. Retinopathy, glucose, and insulin in an elderly population. Diabetes 1995;24:11–15.

    Article  Google Scholar 

  106. Tüyry JP, Niskanen LK, Mäntysaari MJ, Lansimies EA, Uusitupa MIJ. Occurrence, predictors, and clinical significance of autonomic neuropathy in NIDDM. Diabetes 1996;45:308–315.

    Article  Google Scholar 

  107. Trautner C, Iacks A, Haastert B, Plum F, Berger M. Incidence of blindness in relation to diabetes. Diabetes Care 1997;20:1147–1153.

    Article  PubMed  CAS  Google Scholar 

  108. Tanaka Y, Atsumi Y, Matsuoka K, Onuma T, Tohjima T, Kawamori P. Role of glycemic control and blood pressure in the development and progression of nephropathy in elderly Japanese NIDDM patients. Diabetes Care 1995;21:116–120.

    Article  Google Scholar 

  109. de Neeling JND, Beks PJ, Bertelsmann FW, Heine RJ, Bouter LM. Peripheral somatic nerve function in relation to glucose tolerance in an elderly Caucasian population: the Hoorn study. Diabetic Med 1996;13:960–966.

    Article  PubMed  Google Scholar 

  110. Nathan DM, Singer DE, Godine JE, Harrington CH, Perlmuter LC. Retinopathy in older type II diabetics. Diabetes 1986;35:797–801.

    Article  PubMed  CAS  Google Scholar 

  111. Morisaki N, Watanabe S, Kobayashi J, Kanzaki T, Takahashi K, Yokote K, et al. Diabetic control and progression of retinopathy in elderly patients: five-year follow-up study. J Am Geriatr Soc 1994;42: 142–145.

    PubMed  CAS  Google Scholar 

  112. Morisaki N, Yokote K, Tashiro J, Inadera H, Kobayashi J, Kanzaki T, et al. Lipoprotein(a) is a risk factor for diabetic retinopathy in the elderly. J Am Geriatr Soc 1994;42:965–967.

    PubMed  CAS  Google Scholar 

  113. Shorr RI, Ray WA, Daugherty JR, Griffin MR. Individuals sulfonylureas and serious hypoglycemia in older people. J Am Geriatr Soc 1996;44:871–872.

    Google Scholar 

  114. Asplund K, Wilholm B-E, Lithner F. Glibenclamide-associated hypoglycemia: a report of 57 cases. Diabetologia 1983;24:412–417.

    Article  PubMed  CAS  Google Scholar 

  115. Sonnenblick M, Shilo S. Glibenclamide induced prolonged hypoglycemia. Age Aging 1986; 15:185–189.

    Article  CAS  Google Scholar 

  116. Asplund K, Wilholm B-E, Lundman B. Severe hypoglycemia during treatment with glipizide. Diabetic Med 1991;8:726–731.

    Article  PubMed  CAS  Google Scholar 

  117. Rump A, Stahl M, Caduff F, Berger W. 173 insulin-induzierte hypoglykamien mit spitaleinweisung. Dtsch Med Wschr 1987;112:1110–1116.

    Article  PubMed  CAS  Google Scholar 

  118. Weissman PN, Shenkman L, Gregerman RI. Chlorpropamide hyponatremia. N Engl J Med 1971;284: 65–71.

    Article  PubMed  CAS  Google Scholar 

  119. Schen RJ, Benaroya Y. Hypoglycemic coma due to chlorpropamide: observations on twenty-two patients. Age Aging 1976;5:31–36.

    Article  CAS  Google Scholar 

  120. Berger W, Caduff F, Pasquel M, Rump A. Die relative haufigkeit der schweren sulfopnylharnstoff-hypoglykamie in den letzten 25 jahren in der schweiz. Schweiz Med Wschr 1986; 116:145–151.

    PubMed  CAS  Google Scholar 

  121. Stepka M, Rogala H, Czyzyk A. Hypoglycemia; a major problem in the management of diabetes in the elderly. Aging 1993;5:117–121.

    PubMed  CAS  Google Scholar 

  122. Meneilly GS, Cheung E, Tuokko H. Counterregulatory hormone responses to hypoglycemia in the elderly patient with diabetes. Diabetes 1994;3:403–410.

    Article  Google Scholar 

  123. Thomson FJ, Masson EA, Leeming JT, Boulton AJ. Lack of knowledge of symptoms of hypoglycaemia by elderly diabetic patients. Age Aging 1991;20:404–406.

    Article  CAS  Google Scholar 

  124. Burden AC. Awareness of hypoglycemia in diabetes. Lancet 1987;ii:1267.

    Article  Google Scholar 

  125. Berger M. Human insulin: much ado about hypoglycaemia (un)awareness. Diabetologia 1987;30: 829–833.

    Article  PubMed  CAS  Google Scholar 

  126. Meneilly GS, Milberg WP, Tuokko H. Differential effects of human and animal insulin on the responses to hypoglycemia in elderly patients with NIDDM. Diabetes 1995;44:272–277.

    Article  PubMed  CAS  Google Scholar 

  127. Palinkas LA, Barrett-Connor E, Wingard DL. Type 2 diabetes and depressive symptoms in older adults: a population-based study. Diabetic Med 1991;8:532–539.

    Article  PubMed  CAS  Google Scholar 

  128. Tun, PA, Nathan DM, Perlmuter LC. Cognitive and affective disorders in elderly patients with diabetes. Clin Geriatr Med 1990;6:731–746.

    PubMed  CAS  Google Scholar 

  129. Elias PK, Elias MF, D’Agostino RB, Cupples LA, Wilson PW, Silbershatz H, Wolf PA. NIDDM and blood pressure as risk factors for poor cognitive performance. Diabetes Care 1997;20:1388–1395.

    Article  PubMed  CAS  Google Scholar 

  130. Meneilly GS, Cheung E, Tessier D, Yakura C, Tuokko H. The effect of improved glycemic control on cognifive functions in the elderly patient with diabetes. J. Gerontol 1993;48:M117–M121.

    PubMed  CAS  Google Scholar 

  131. Gradman TJ, Laws A, Thompson LW, Reaven GM. Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. J Am Geriatr Soc 1993;41:1305–1312.

    PubMed  CAS  Google Scholar 

  132. Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O’Brien PC, Palumbo PJ. Risk of dementia among persons with diabetes mellitus: a population-based cohort study. Am J Epidemiol 1997; 145: 301–308.

    Article  PubMed  CAS  Google Scholar 

  133. Ott A, Stolk RP, Hofman A, van Harskamp F, Grobbee DE, Breterler MMB. Association of diabetes mellitus and dementia: the Rotterdam study. Diabetologia 1996;39:1392–1397.

    Article  PubMed  CAS  Google Scholar 

  134. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979;28:1039–1057.

    Google Scholar 

  135. American Diabetes Association. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1988;21(Suppl I):S5-S19.

    Google Scholar 

  136. Cefalu WT, Ettinger WH, Bell-Farrow AD, Rushing JT. Serum fructosamine as a screening test for diabetes in the elderly: a pilot study. J Am Geriatr Soc 1993;41:1090–1094.

    PubMed  CAS  Google Scholar 

  137. Croxson SCM, Absalom S, Burden AC. Fructosamine in diabetes screening of the elderly. Ann Clin Biochem 1991;28:279–282.

    PubMed  Google Scholar 

  138. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–986.

    Article  Google Scholar 

  139. Meinert CL, Knatterud GL, Prout TE, Klimt TR. A study of the effects of hypoglycemic agents on vascular complications in patients with adult onset diabetes mellitus. Diabetes 1970;19:789–830.

    PubMed  Google Scholar 

  140. Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Dia Res Clin Pract 1995; 28:103–117.

    Article  CAS  Google Scholar 

  141. UK Prospective Diabetes Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 1998;352:837–853.

    Article  Google Scholar 

  142. UK Prospective Diabetes Group. Efficacy of aterolol and captopril in reducing risk of macro vascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ 1998;317:713–720.

    Article  Google Scholar 

  143. Manton KG, Stallard E. Cross-sectional estimates of active life expectancy for the US elderly and oldest-old populations. J Gerontol 1991;46:S160-S182.

    Google Scholar 

  144. Eastman RC, Javitt JC, Herman WH, Dasbach EJ, Dong F, Manninen, D, et al. Model of complications of NIDDM. I. Diabetes Care 1997;20:725–734.

    Article  PubMed  CAS  Google Scholar 

  145. Eastman RC, Javitt JC, Herman WH, Dasbach EJ, Dong F, Manninen, D, et al. Model of complications of NIDDM. II. Diabetes Care 1997;20:735–744.

    Article  PubMed  CAS  Google Scholar 

  146. Vijan S, Hofer TP, Hayward RA. Estimated benefits of glycerine control in microvascular complica-tions in type 2 diabetes. Ann Int Med 1997;127:788–795.

    PubMed  CAS  Google Scholar 

  147. Avorn J. Benefit and cost analysis in geriatric care. New Engl J Med 1984;310:1294–1301.

    Article  PubMed  CAS  Google Scholar 

  148. Holvey SM. Psychosocial aspects in the care of elderly diabetic patients. Am J Med 1986;80(Suppl 5A): 61–63.

    Article  PubMed  CAS  Google Scholar 

  149. Funnell MM. Role of diabetes educator for older adults. Diabetes Care 1990;13(Suppl 2):60–65.

    Google Scholar 

  150. Kronsbein P, Muhlhauser I, Venhaus A, Jorgens V, Scholz V, Berger M. Evaluation of structured treatment and teaching program on non-insulin-dependent diabetes mellitus (NIDDM). Am J Public Health 1987;77:634–635.

    Article  Google Scholar 

  151. Wilson W, Pratt C. The impact of diabetes education and peer support upon weight and glycemic control of elderly persons with NIDDM. Am J Public Health 1987;77:635–637.

    Article  Google Scholar 

  152. Gilden JL, Hendryx M, Casia C, Singh SP. The effectiveness of diabetes education programs for older patients and their spouses. J Am Geriatr Soc 1989;37:1023–1030.

    PubMed  CAS  Google Scholar 

  153. Silliman RA, Bhatta S, Khan A, Dukes KA, Sullivan LM. The care of older persons with diabetes mellitus: families and primary care physicians. J Am Geriatr Soc 1996;44:1314–1321.

    PubMed  CAS  Google Scholar 

  154. Petterson T, Dornan TL, Albert T, Lee P. Are information leaflets given to elderly people with diabetes easy to read? Diabetic Med; 1994;11:111–113.

    Article  PubMed  CAS  Google Scholar 

  155. Leggett-Frazier N, Turner MS, Vincent PA. Measuring the diabetes knowledge of nurses in long-term care facilities. Diabetes Educator 1994;20:307–310.

    Article  PubMed  CAS  Google Scholar 

  156. Siegel J. Barriers to the effective use of capilllary blood glucose monitoring in extended care facilities. Diabetes Care 1990;17:381–383.

    Google Scholar 

  157. Funnell M, Herman W. Diabetes care policies and practices in Michigan nursing homes, 1991. Diabetes Care 1995;18:862–866.

    Article  PubMed  CAS  Google Scholar 

  158. Tonino RP. Diabetes education. What should health care providers in long term care facilities know about diabetes. Diabetes Care 1990;13(Suppl 2):55–59.

    Google Scholar 

  159. Giugliano D, Saccomanno F, Paolisso G, Ceriello A, Terella R, Varicchio M, et al. Nicardipine does not cause deterioration of glucose homeostasis in man: a placebo controlled study in elderly hypertensives with and without diabetes mellitus. Eur J Clin Pharmacol 1992;43:39–45.

    Article  PubMed  CAS  Google Scholar 

  160. Antonicelli R, Pagelli P, Paciaroni E. Nicardipine retard in the therapy of elderly diabetic hypertensives: final report of observational study. J Hypertension 1992;10(Suppl 2):569–572.

    Google Scholar 

  161. Lusardi P, Corradi L, Pasotti P, Zoppi G, Preti P, et al. Effects of amlodipine vs fosinopril on micro-albuminuria in elderly hypertensive patients with type II diabetes. J Hypertension 1996;14(Suppl): S193.

    Google Scholar 

  162. Estacio RO, Jeffers BW, Hiatt WR, Biggerstaff SL, Gifford N, Schrier RW. The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension. N Engl J Med 1998;338:645–682.

    Article  PubMed  CAS  Google Scholar 

  163. Tatti P, Pahor M, Byington RP, Di Mauro P, et al. Outcome results of the fosinopril versus amlodipine cardiovascular events randomized trial (FACET) in patients with hypertension and NIDDM. Diabetes Care 1998;21:597–603.

    Article  PubMed  CAS  Google Scholar 

  164. Curb JD, Pressel SL, Cutler JA, Savage PJ, Applegate WB, Black H, et al. Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. JAMA 1996;276:1886–1891.

    Article  PubMed  CAS  Google Scholar 

  165. Watson N, Sandler M. Effects of captopril on glucose tolerance in elderly patients with congestive cardiac failure. Curr Med Res Opin 1991;12:374–378.

    Article  PubMed  CAS  Google Scholar 

  166. Paolisso G, Gambardella A, Verza M, D’Amore A, Sgambato S, Varicchio M. ACE inhibition improves insulin-sensitivity in aged insulin-resistant hypertensive patients. J Hum Hypertens 1992;6: 175–179.

    PubMed  CAS  Google Scholar 

  167. Fonseca V, Wall J. Diet and diabetes in the elderly. Clin Geriatr Med 1995;11:613–624.

    PubMed  CAS  Google Scholar 

  168. Reed RL, Mooradian AD. Nutritional status and dietary management of elderly diabetic patients. Clin Geriatr Med 1990;6:883–901.

    PubMed  CAS  Google Scholar 

  169. Horwath CC, Worsley A. Dietary habits of elderly persons with diabetes. J Am Diet Assoc 1991;91: 553–557.

    PubMed  CAS  Google Scholar 

  170. Reaven GM. Beneficial effect of moderate weight loss in older patients with non-insulin-dependent diabetes mellitus poorly controlled with insulin. J Am Geriatr Soc 1985;33:93–95.

    PubMed  CAS  Google Scholar 

  171. Coulston M, Mandelbaum D, Reaven GM. Dietary management of nursing home residents with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1990;51:67–71.

    PubMed  CAS  Google Scholar 

  172. Paolisso G, Passariello G, Pizza G, Marrazzo R, Giunta R, Sgambato S, et al. Dietary Magnesium supplements improve B-cell response to glucose and arginine in elderly non-insulin dependent diabetic subjects. Acta Endocrinol 1989;121:16–20, 121.

    Google Scholar 

  173. Paolisso G, Scheen A, Cozzolino D, De Maro G, Varricchio M, D’Onofrio F, et al. Changes in glucose turnover parameters and improvement of glucose oxidation after 4-week magnesium administration in elderly non-insulin-dependent (type II) diabetic patients. J Clin Endocrinol Metab 1994;78:1510–1515.

    Article  PubMed  CAS  Google Scholar 

  174. Morley JE, Mooradian AD, Rosenthal MJ, Kaiser FE. Diabetes mellitus in elderly patients. Am J Med 1987;83:533–544.

    Article  PubMed  CAS  Google Scholar 

  175. Song MK, Rosenthal MJ, Naliboff BD, Phanumas L, Kang KW. Effects of bovine prostate powder on zinc, glucose and insulin metabolism in old patients with non-insulin-dependent diabetes mellitus. Metabolism 1998;47:39–43.

    Article  PubMed  CAS  Google Scholar 

  176. Aguirre F, Martin I, Grinspon D, et al. Oxidation damage, plasma antioxidant capacity, and glucemic control in elderly NIDDM patients. Free Radicals Biol Med 1998;24:580–585.

    Article  CAS  Google Scholar 

  177. Paolisso G, D’Amore A, Volpe C, Balbi V, et al. Evidence for a relationship between oxidative stress and insulin action in non-insulin-dependent diabetic patients. Metabolism 1994;43:1426–1429.

    Article  PubMed  CAS  Google Scholar 

  178. Paolisso G, D’Amore A, Balbi V, Volpe C, et al. Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics. Am J Physiol 1994;266:E261–E268.

    PubMed  CAS  Google Scholar 

  179. Paolisso G, D’Amore A, Galzerano D, Balbi V, Giugliano D, Varricchio M, D’Onofrio F. Daily vitamin E supplements improve metabolic control but not insulin secretoin in elderly type II diabetic patients. Diabetes Care 1993;16:1433–1437.

    Article  PubMed  CAS  Google Scholar 

  180. Ivy JL. Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Sports Med 1997;24:321–336.

    Article  PubMed  CAS  Google Scholar 

  181. Skarfors ET, Wegbener TA, Lithell H, Selinus I. Physical training as treatment for type 2 (non-insulin-dependent) diabetes in elderly men. A feasibility study over 2 years. Diabetologia 1987;30:930–933.

    Article  PubMed  CAS  Google Scholar 

  182. Orimo H, Akiguchi I, Shiraki M. Usefulness of acarbose in the management of non-insulin-dependent diabetes in the aged. In: Creutzfelt W, ed. Acarbose. Excerpta Medica, Amsterdam, 1982, pp. 348–352.

    Google Scholar 

  183. Johansen K. Acarbose treatment of sulfonylurea-treated non-insulin dependent diabetics. Diabete Metabol 1984;10:219–223.

    CAS  Google Scholar 

  184. Spengler M, Cagatay M. Evaluation of efficacy and tolerability of acarbose by postmarketing surveillance. Diab Stoffw 1992;1:218–222.

    Google Scholar 

  185. Johnston PS, Lebovitz HE, Coniff RF, Simonson DC, Raskin P, Munera CL. Advantages of α-glucosidase inhibition as monotherapy in elderly type 2 diabetic patients. J Clin Endocrinol Metabol 1998; 83:1515–1522.

    Article  CAS  Google Scholar 

  186. Knight PV, Temple G, Kessen CM. The use of metformin in the older patient. J Clin Exp Gerontol 1986;8:57–58.

    Google Scholar 

  187. Josephkutty S, Potter JM. Comparison of tolbutamide and metformin in elderly diabetic patients. Diabetic Med 1990;7:510–514.

    Article  PubMed  CAS  Google Scholar 

  188. Lalau JD, Vrmersch, Hary L, Andrejak M, Isnard F, Quichaud J. Type 2 diabetes in the elderly: an assessment of metformin (metformin in the elderly). Int J Clin Pharmacol Ther Toxicol 1990;28:329–332.

    PubMed  CAS  Google Scholar 

  189. Puxty JAH, Hunter DH, Burr WA. Accuracy of insulin injection in elderly patients. Br Med J 1983; 287:1762.

    Article  CAS  Google Scholar 

  190. Kesson CM, Bailie GR. Do diabetic patients inject accurate doses of insulin? Diabetes Care 1981;4:333.

    PubMed  CAS  Google Scholar 

  191. Coscelli C, Calabrese G, Fedele D, Pisu E, Calderini C, Bistoni S, et al. Use of premixed insulin among the elderly. Diabetes Care 1992;15:1628–1630.

    Article  PubMed  CAS  Google Scholar 

  192. Brodows R, Chessor R. A comparison of premixed insulin preparations in elderly patients. Diabetes Care 1995;18:855–857.

    Article  PubMed  CAS  Google Scholar 

  193. Kyallastinen M, Groop L. Combination of insulin and glibenclamide in the treatment of elderly non-insulin-dependent (Type 2) diabetic patients. Ann Clin Res 1985;17:100–104.

    Google Scholar 

  194. Wolffenbuttel BHR, Sels, J-P JE, Rondas-Colbers GJWM, Menheere PPCA, Nieuwenhuijzen Kruseman AC Comparison of different insulin regimens in elderly patients with NIDDM. Diabetes Care 1996;19:1326–1332.

    Article  PubMed  CAS  Google Scholar 

  195. Bergman U, Christensen I, Jansson B, Wilholm B-E, Ostman J. Wide variation in serum chlorpropamide concentration in outpatients. Eur J Clin Pharmacol 1980;18:165–169.

    Article  PubMed  CAS  Google Scholar 

  196. Kobayashi KA, Bauer LA, Horn JR, Opheim K, Wood F, Kradjan WA. Glipizide pharmacokinetics in young and elderly volunteers. Clin Pharm 1988;7:224–228.

    PubMed  CAS  Google Scholar 

  197. Sartor G, Melander A, Schersten B, Wahlin-Boll E. Influence of food and age on the single-dose kinetics and effects of tolbutamide and chlorpropamide. Eur J Clin Pharmacol 1980;17:285–293.

    Article  PubMed  CAS  Google Scholar 

  198. Adir J, Miller AK, Vestal RE. Effects of total plasma concentration and age on tolbutamide plasma protein binding. Clin Pharmacol Ther 1982;31:488–493.

    Article  PubMed  CAS  Google Scholar 

  199. Schwinghammer TL, Antal EJ, Kubacka RT, Hackimer ME, Johnston JM. Pharmacokinetics and pharmacodynamics of glyburide in young and elderly nondiabetic adults. Clin Pharm 1991;10:532–538.

    PubMed  CAS  Google Scholar 

  200. Jaber LA, Antal EJ, Welshman IR. Pharmacokinetics and pharmacodynamics of glyburide in young and elderly patients with non-insulin-dependent diabetes mellitus. Ann Pharmacother 1996;30: 472–475.

    PubMed  CAS  Google Scholar 

  201. Kadowaki T, Hagura R, Kajinuma H, Kuzuya N, Yoshida S. Chlorpropamide-induced hyponatremia: incidence and risk factors. Diabetes Care 1983;6:468–471.

    Article  PubMed  CAS  Google Scholar 

  202. Tanay A, Firemann Z, Yust I, Abramov AL. Chlorpropamide-induced syndrome of inappropriate antidiuretic hormone secretion. J Am Geriatr Soc 1981;29:334–336.

    PubMed  CAS  Google Scholar 

  203. Rosenstock J, Corrao PJ, Goldberg RB, Kilo C. Diabetes control in the elderly: a randomized, com-parative study of glyburide versus glipizide in non-insulin-dependent diabetes mellitus. Clin Thera-peutics 1993;15:1031–1040.

    CAS  Google Scholar 

  204. Brodows RG. Benefits and risks with glyburide and glicazide in elderly NIDDM patients. Diabetes Care 1992;15:75–80.

    Article  PubMed  CAS  Google Scholar 

  205. Fruhwalt T, Bohmer F. Gliclazid beim nichtinsulinpflchtigen diabetiker in der geriatrie. Schweiz Med Wochenschr 1988;138:102–106.

    Google Scholar 

  206. Tessier D, Dawson K, Tetrault JP, Bravo G, Meneilly GS. Glibenclamide vs glicazide in type 2 diabetes of the elderly. Diabetic Med 1994;11:974–980.

    Article  PubMed  CAS  Google Scholar 

  207. Chan TY, Cheung AY. Predictors of relapse in elderly diabetic patients admitted with sulphonylurea-induced severe hypoglycaemic attacks. Age Aging 1997;26:409–410.

    CAS  Google Scholar 

  208. Connolly VM, Gallagher A, Kesson CM. A study of fluoxetine in obese elderly patients with type 2 diabetes. Diabetic Med 1994;12:416–418.

    Article  Google Scholar 

  209. Gilden JL, Casia C, Hendryx M, Singh SP. Effects of self-monitoring of blood glucose on quality of life in elderly diabetic patients. J Am Geriatr Soc 1990;28:511–515.

    Google Scholar 

  210. Bernbaum M, Albert SG, McGinnis J, Bursca S, Mooradian AD. The reliability of self blood glucose monitoring in elderly diabetic patients. J Am Geriatr Soc 1994;42:779–791.

    PubMed  CAS  Google Scholar 

  211. Cefalu WT, Prather KL, Murphy WA, Parker TB. Clinical evaluation of serum fructosamine in moni-toring elderly outpatient diabetics. J Am Geriatr Soc 1989;37:833–837.

    PubMed  CAS  Google Scholar 

  212. Negoro H, Morley JE, Rosenthal MJ. Utility of serum fructosamine as a measure of glycemia in young and old diabetic and non-diabetic subjects. Am J Med 1988;85:360–364.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Graydon S. Meneilly MD, FRCPC
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  2. Daniel Tessier MD, FRCPC
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  1. Sciences Center, Saint Louis University Health, St. Louis, MO, USA

    John E. Morley MB, BCh  & Lucretia van den Berg MB, BCh  & 

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Meneilly, G.S., Tessier, D. (2000). Diabetes in the Elderly. In: Morley, J.E., van den Berg, L. (eds) Endocrinology of Aging. Contemporary Endocrinology, vol 20. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-715-4_12

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