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Tumor Hypoglycemia Linked to IGF-II

  • Chapter
The IGF System

Part of the book series: Contemporary Endocrinology ((COE,volume 17))

Abstract

Hypoglycemia is a common medical emergency, most often due to untoward effects of insulin administered to patients with diabetes mellitus. It is also a manifestation of many other medical conditions including tumors. The hypoglycemia associated with tumors occurs within a subset of patients who have “spontaneous” or fasting hypoglycemia, i.e., the fall in blood glucose to subnormal levels occurs apparently unprovoked several hours after the patient has last eaten. Historically, the first and still the most common tumors with hypoglycemia are insulinomas, the insulin-secreting tumors of the endocrine pancreas. All other tumors associated with hypoglycemia are referred to under the broad rubric of non-islet-cell tumors with hypoglycemia (NICTH). The most important group of patients with NICTH are those who harbor tumors that secrete an incompletely processed form of insulin-like growth factor-II (IGF-II), known as big IGF-II. The tumor types included in this group are extremely numerous and are the major focus of our discussion.

Contributed equally.

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Authors
  1. Christian A. Koch MD
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  2. Kristina I. Rother MD
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  3. Jesse Roth MD, FACP
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, OR, USA

    Ron G. Rosenfeld MD

  2. Oregon Health Sciences University, Portland, OR, USA

    Charles T. Roberts Jr. PhD

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Koch, C.A., Rother, K.I., Roth, J. (1999). Tumor Hypoglycemia Linked to IGF-II. In: Rosenfeld, R.G., Roberts, C.T. (eds) The IGF System. Contemporary Endocrinology, vol 17. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-712-3_28

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  • DOI: https://doi.org/10.1007/978-1-59259-712-3_28

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-138-7

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