Abstract
Pain is the most impressive symptom of a disturbed homeostasis in a segment of the body or an organ. It originates (with few exceptions) from stimulation of the so-called tissue nociceptors. Their stimulation results in depolarisation of C-fibers. The stimulus will be transferred to the dorsal horn of the spinal cord, and may then, depending on facilitating or inhibiting modulation, be conducted through the spinothalamic tract to the medulla oblongata (1,2). Here, in the hypothalamus and the thalamus, additional processing takes place before the information is translated into the sensation of “pain.” The subjective feeling of pain may be influenced by further factors such as distraction. In principle, the production of pain can be modulated, either amplified or reduced, at all of the aforementioned levels.
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Brune, K. (1999). Antipyretic Analgesic Drugs. In: Nahas, G.G., Sutin, K.M., Harvey, D., Agurell, S., Pace, N., Cancro, R. (eds) Marihuana and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-710-9_48
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DOI: https://doi.org/10.1007/978-1-59259-710-9_48
Publisher Name: Humana Press, Totowa, NJ
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