Abstract
A single prenatal exposure to cannabinol or cannabidiol reduced brain norepinephrine and dopamine and hypothalamic NE concentrations, but increased brain levels of serotonin and its metabolite, 5-hydroxyindoleacetic acid. In addition, testicular testosterone concentrations and seminal vesicles weights were reduced in animals exposed to CBN. In contrast, seminal vesicles weights were increased in CBD-exposed males. Prenatal exposure to the major psychoactive component of marihuana, δ9-tetrahydrocannabinol on one of the last four days of gestation did not affect these parameters.
The F1 male offspring of male mice treated with CBN, CBD, or THC presented evidence of reduced fertility and testicular chromosomal abnormalities. In addition, two of the F1 male offspring of the THC-treated mice sired litters containing pups with severe congenital malformations.
These findings indicate that maternal or paternal exposure to cannabinoids can influence developmental and reproductive functions in offspring. Thus, cannabinoids appear to be both mutagenic and teratogenic in mice.
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References
Bloch, E., Thysen, B., Morrill, G. A., Gardner, E. and Fujimoto, G. (1978) Effects of cannabinoids on reproduction and development. Vitam. Horm. 36, 203–258.
Kolodny, R. C., Lessin, P., Toro, G., Masters, W. H. and Cohen, S. (1976) Depression of plasma testosterone with acute marihuana administration, in The Pharmacology of Marihuana ( Braude, M. C. and Szara, S., eds.), Raven, Press, New York, pp. 217–225.
Kolodny, R. C., Masters, W. H., Kolodner, R. M. and Toro, G. (1974) depression of plasma testosterone levels after chronic intensive marihuana use. N. Engl. J. Med. 290, 872–874.
Dalterio, S., Bartke, A., Roberson, C., Watson D. and Burstein, S. (1978) Direct and pituitary-mediated effects of 09-THC and cannabinol on the testis. Pharmacol. Biochem. Behay. 8, 673–678.
Dalterio, S. (1980) Perinatal or adult exposure to cannabinoids alters male reproductive functions in mice. Pharmacol. Biochem. Behay. 12, 143–153.
Dalterio, S. and Bartke, A. (1979) Perinatal exposure to cannabinoids alters male reproductive function in mice. Science 205, 1420–1422.
Kramer, J. and Ben-David, M. (1978) Prolactin suppression by (-)-09-tetrahydrocannabinol (THC): involvement of serotonergic and dopaminergic pathways. Endocrinology 103 452–457.
Smith, C. G., Besch, N. F., Smith, R. G. and Besch, P. K. (1979) Effects of tetrahydrocannabinol on the hypothalamic-pituitary axis in the ovariectomized Rhesus monkey. Fertil. Steril. 31, 335–339.
Asch, R. H., Smith, C. G., Siler-Knodr, T. M. and Pauerstein, C. J. (1979) Effects of 09- tetrahydrocannabinol on gonadal steroidogenic activity in vivo. Fertil. Steril. 32, 576–582.
Fuxe, K. and Johnson, G. (1971) The effect of tetrahydrocannabinol on central monoamine neurons. Acta Pharm. Suec. 8, 695–701.
Ho, B. T., Taylor, D. V., Fritchie, G. E., Englert, G. E. and Mclsaac, W. M. (1973) Neuropharmacological study of A9-tetrahydrocannabinol in monkeys and mice. Brain Res. 38, 163–170.
Han-is, L. S., Dewey, W. L. and Razdan, R. (1972) Cannabis: it’s chemistry, pharmacology, and toxicology, in Drug Addiction II (Martin, W. R., ed.) Handbook of Experimental Pharmacology, 45, 371–429.
Dewey, W. L., Poddar, M. K. and Johnson, K. M. (1979) The effects of cannabinoids on rat brain synaptosomes, in Marihuana, Biologic Effects ( Nahas, G. G. and Paton, W. D. M. eds.) Pergamon, Oxford, UK p. 343.
Bloom, A. S. (1982) Effect of 09-tetrahydrocannabinol on the synthesis of dopamine and norepinephrine in mouse brain synaptosomes. J. Pharmacol. Exp. Ther. 221, 97–103.
Dalterio, S., Badr, F., Bartke, A. and Mayfield, D. (1982) Cannabinoids in male mice: effects on fertility and spermatogenesis. Science 216, 315–316.
Tyrey, L. (1980) Y-tetrahydrocannabinol: a potent inhibitor of episodic luteinizing hormone secretion. J. Pharmacol. Exp. Ther. 213, 300–308.
Jakubovic, A., McGeer, E. G. and McGeer, P. L. (1979) Effects of cannabinoids on testosterone and protein synthesis in rat testis Leydig cells in vitro. Molec. Cell. Endocrinol. 15, 41–50.
Burstein, S., Levin, E. and Varanelli, C. (1973) Prostaglandins and cannabis II: inhibition of biosynthesis by the naturally occurring cannabinoids. Biochem. Pharmacol. 22, 2905–2910.
Dalterio, S., Bartke, A., Harper, M. J. K., Huffman, R. and Sweeney, C. (1981) Effects of cannabinoids and female exposure on the pituitary-testicular axis in mice: possible involvement of prostaglandins. Biol. Reprod. 24, 315–322.
Husain, S. and Lame, M. W. (1981) Inhibitory effects of A9-tetrahydrocannabinol on glycolytic substrates in the rat testis. Pharmacology 23, 102–112.
Shoupe, T. S., Hunter, S. A., Burstein, S. H. and Hubbard, C. D. (1980) Nature of the inhibition of cholesterol esterase by Al-tetrahydrocannabinol. Enzyme 25, 87–91.
Burstein, S., Hunter, S. A. and Shoupe, T. S. (1979) Site of inhibition of Leydig cell testosterone by Altetrahydrocannabinol. Molec. Pharmacol. 15, 663–640.
Dixit, V. P., Sharma, V. N. and Lohiya, N. K. (1974) The effect of chronically administered cannabis extract on the testicular function in mice. Eur. J. Pharmacol. 26, 111–114.
Hembree, W. C., Nahas, G. G., Zeidenberg, P. and Dyrenfurth, I. (1976) Marihuana effects of the human testis. Clin. Res. 24, 272A.
Issidorides, M. R. (1979) Observations in chronic marihuana users: nuclear aberrations in blood and sperm and abnormal acrosomes in spermatozoa, in Marihuana, Biological Effects ( Nahas, G. G. and Paton, W. D. M. eds.) Pergamon, Oxford, UK, p 377.
Luthra, Y. K. (1979) Brain biochemical alterations in neonates of dams treated orally with A9-tetrahydrocannabinol during gestation lactation, in Marihuana, Biological Effects ( Nahas, G. G. and Paton, W. D. M., eds.) Pergamon, Press, Oxford, UK, p. 531.
Fried, P. A. (1976) Short and long term effects of prenatal cannabis inhalation upon rat offspring. Psychopharmacology 50, 285–291.
Raduoco-Thomas, S., Magnan, F., Grove, R. N., Singh, P., Garcon, F. and Raduoco-Thomas, C. (1976) Effect of chronic administration of A9-THC on learning and memory in developing mice, in The Pharmacology of Marihuana ( Braude, M. C. and Szara, S, eds.) Raven, New York, p. 487.
Steger, R. W., DePaolo, L., Asch, R. H., and Silverman, A. V. (1982) Interactions of A9- tetrahydrocannabinol (THC) with hypothalamic neurotransmitters controlling luteinizing hormone and prolactin release. Neuroendocrinology (submitted).
Steger, R. W., Bartke, A. and Goldman, B. D. (1982) Alterations in neuroendocrine function during photoperiod-induced testicular atrophy and recrudiscence in the golden hamster. Biol. Reprod. 26, 437–444.
Bapna, J., Neff, N. H. and Costa, E. (1971) A method for studying norepinephrine and serotonin metabolism in small regions of the brain: effect of ovariectomy on amine metabolism in anterior and posterior hypothalamus. Endocrinology 89, 1345–1349.
Dalterio, S., Michael, S. D., Macmillan, B. T. and Bartke, A. (1981) Differential effects cannabinoid exposure and stress have on plasma prolactin, growth hormone and corticosterone levels in male mice. Life Sci. 28, 761–766.
Dalterio, S., Bartke, A. and Sweeney, C. (1981) Interactive effects of ethanol and A9- tetrahydrocannabinolon endocrine functions in male mice. J. Androl. 2, 87–93.
Barraclough, C. A. and Wise, P. M. (1982) The role of catecholamines in the regulation of pituitary luteinizing hormone and follicle-stimulating hormone secretion. Endocrinol. Rev. 3, 91–119.
Dalterio, S., Blum, K., Dellalo, L., Sweeney, C., Briggs, A. and Bartke, A. (1980) Perinatal exposure to A9THC in mice: altered enkephalin and norepinephrine sensitivity in vas deferens. Subs. Alcohol Actions/Misuse 1, 467–478.
Gessa, G. L. and Tagliamonte, A. (1975) Role of brain serotonin and dopamine in male sexual behavior, in Sexual Behavior: Pharmacology and Biochemistry Raven, New York, p. 117.
Wise, P. M., Rance, N. and Barraclough, C. A. (1981) Effects of estradiol and progesterone on catecholamine turnover in discrete hypothalamic regions on ovariectomized rats. Endocrinology 108 2186–2193.
Dalterio, S., Bartke, A., Michael, S. and Macmillan, B. (1980) Gonadal steroids influence the effects of A9tetrahydrocannabinol in male mice. Biol. Reprod. 22, 117A.
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Dalterio, S.L., Steger, R.W., Bartke, A. (1999). Maternal or Paternal Exposure to Cannabinoids Affects Central Neurotransmitter Levels and Reproductive Function in Male Offspring. In: Nahas, G.G., Sutin, K.M., Harvey, D., Agurell, S., Pace, N., Cancro, R. (eds) Marihuana and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-710-9_43
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DOI: https://doi.org/10.1007/978-1-59259-710-9_43
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