Skip to main content
SpringerLink
Log in

Dependence, Tolerance, and Alteration in Gene Expression

  • Chapter
Marihuana and Medicine

Abstract

The rewarding effects of drugs of abuse such as stimulants, opiates, and cannabinoids appear to depend on the mesolimbic dopamine pathway and related brain regions in the basal ganglia. Activation of dopamine receptors causes induction of various genes. One such gene, fosB, plays a critical role in the rewarding effects of stimulants. This transcription factor may be a mediator of a drug’s abusive properties.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Koob, G. F. and LeMoal, M. (1997) Science 278, 52–58.

    Article  PubMed  CAS  Google Scholar 

  2. Nestler, E. J. and Aghajanian, G. K. (1997) Science 278, 58–62.

    Article  PubMed  CAS  Google Scholar 

  3. Hiroi, N. and White, N. M. (1991) J. Neurosci. 11, 2107–2116.

    PubMed  CAS  Google Scholar 

  4. Rodriguez de Fonesca, F., Carrera, M. R. A., Navarro, M., and Koob, G. F. Weiss, F. (1997) Science 276, 2050–2054.

    Article  Google Scholar 

  5. Hiroi, N. and White, N. M. (1993) Neurosci. Lett. 156, 9–12.

    Article  PubMed  CAS  Google Scholar 

  6. Hubner, C. B. and Koob, G. F. (1990) Brain Res. 508, 20–29.

    Article  PubMed  CAS  Google Scholar 

  7. Gardner, E. L. and Vorel, S. R. (1998) Seminars in the Neurosci. in press.

    Google Scholar 

  8. Chen, J., Paredes, W., Li, J., Smith, D., Lowinson, J., and Gardner, E. L. (1990) Psychopharmacol. 102, 156–162.

    Article  CAS  Google Scholar 

  9. Chen, J., Marmur, R., Pulles, A., Paredes, W., and Gardner, E. L. (1993) Brain Res. 621, 65–70.

    Article  PubMed  CAS  Google Scholar 

  10. Tanda, G., Pontien, F. E., and DiChiara, G. (1997) Science 276, 2048–2050.

    Article  PubMed  CAS  Google Scholar 

  11. Lepore, M., Vorel, S. R., Lowinson, J., and Gardner, E. L. (1995) Life Sci. 56, 2073–2080.

    Article  PubMed  CAS  Google Scholar 

  12. White, N. M. and Hiroi, N. (1993) Sem. Neurosci. 5, 329–336.

    Article  CAS  Google Scholar 

  13. Sanudo-Pena, M. C., Tsou, K., Delay, E. R., Hohman, A. G., Force, M., and Walker, J. M. (1997) Neurosci. Lett. 223, 125–128.

    Article  PubMed  CAS  Google Scholar 

  14. Harris, R. T., Waters, W., and McLendon, D. (1974) Psychopharmacology 37, 23–29.

    Article  CAS  Google Scholar 

  15. Kaymakcalan, S. (1972) In: Cannabis and its Derivatives (Paton, W. D. M., and Cowan, J. eds.) Oxford, London, UK, pp. 142–149.

    Google Scholar 

  16. Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., and Bonner, T. I (1990) Nature 346, 561–564.

    Article  PubMed  CAS  Google Scholar 

  17. Shire, D., Carillon, C., Kaghad, M., Calandra, B., Rinaldi-Carmona, M., Le Fur, G., Caput, D., and Ferrara, P. (1995) J. Biol. Chem. 270, 3726–3731.

    Article  PubMed  CAS  Google Scholar 

  18. Howlett, A. C. (1985) Mol. Pharmacol. 27, 429–436.

    PubMed  CAS  Google Scholar 

  19. Howlett, A. C., Qualy, J. M., and Khachatrian, L. L. (1986) Mol. Pharmacol. 29, 307–313.

    PubMed  CAS  Google Scholar 

  20. Rinaldi-Carmona, M., Calandra, B., Shire, D., Bouaboula, M., Oustric, D., Barth, F., Casellas, P., Ferrara, P., and Le Fur, G. (1996) J. Pharmacol. Exp. Ther. 278, 871–878.

    PubMed  CAS  Google Scholar 

  21. Herkenham, M., Lynn, A. B., de Costa, B. R., and Richfield, E. K. (1991) Brain Res. 547, 267–274.

    Article  PubMed  CAS  Google Scholar 

  22. Herkenham, M., Lynn, A. B., Johnson, M. R., Melvin, L. S., deCosta, B. R., and Rice, K. C. (1991) J. Neurosci. 11, 563–583.

    PubMed  CAS  Google Scholar 

  23. Mailleux, P. and Vanderhaeghen, J. J. (1992) Neurosci. 48, 655–668.

    Article  CAS  Google Scholar 

  24. Matsuda, L. A., Bonner, T. I., and Lolait, S. J. (1993).1. Comp. Neurol. 327, 535–550.

    Google Scholar 

  25. Westlake, T. M., Howlett, A. C., Bonner, T. I., Matsuda, L. A., and Herkenham, M. (1994) Neurosci. 63, 637–652.

    Article  CAS  Google Scholar 

  26. Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M.R., Melvin, L. S., deCorta, B. R., Rice, K.C. (1990) Proc. Natl. Acad. Sci. USA 87, 1932–1936.

    Article  PubMed  CAS  Google Scholar 

  27. Bidaut-Russell, M. and Howlett, A. (1991) J. Neurochem. 57, 1769–1773.

    Article  PubMed  CAS  Google Scholar 

  28. Felder, C. C., Veluz, J. S., Williams, H. L., Briley, E. M., and Matsuda, L. A. (1992) Mol. Pharmacol. 42, 838–845.

    PubMed  CAS  Google Scholar 

  29. Glass, M. and Felder, C. C. (1997) J. Neurosci. 17, 5327–5333.

    PubMed  CAS  Google Scholar 

  30. Sheng, M. and Greenberg, M. E. (1990) Neuron 4, 477–485.

    Article  PubMed  CAS  Google Scholar 

  31. Morgan, J. I. and Curran, T. (1991) Ann. Rev. Neurosci. 14, 421–451.

    Article  PubMed  CAS  Google Scholar 

  32. Graybiel, A. M., Moratalla, R., and Robertson, H. A. (1990) Proc. Natl. Acad. Sci. USA 87, 6912–6916.

    Article  PubMed  CAS  Google Scholar 

  33. Young, S. T., Porrino, L. J., and Iadarola, M. J. (1991) Proc. Natl. Acad. Sci. USA 88, 1291–1295.

    Article  PubMed  CAS  Google Scholar 

  34. Nye, H. E., Hope, B. T., Kelz, M. B., Iadarola, M. J., and Nestler, E. J. (1995) J. Pharmacol. Exp. Ther. 275, 1671–1680.

    PubMed  CAS  Google Scholar 

  35. Moratalla, R., Xu, M., Tonegawa, S., and Graybiel, A. M. (1996) Proc. Natl. Acad. Sci. USA 93, 14928–14933.

    Article  PubMed  CAS  Google Scholar 

  36. Cole, A. J., Bhat, R. V., Patt, C., Worley, P. F., and Baraban, J. M. (1992) J. Neurochem. 58, 1420–1426.

    Article  PubMed  CAS  Google Scholar 

  37. Hope, B. T., Kosofsky, B., Hyman, S. E., and Nestler, E. J. (1992) Proc. Natl. Acad. Sci. USA 89, 5764–5768.

    Article  PubMed  CAS  Google Scholar 

  38. Hope, B. T., Nye, H. E., Kelz, M. B., Self, D. W., Iadarola, M. J., Nakabeppu, Y., Duman, R. S., and Nestler, E. J. (1994) Neuron 13, 1235–1244.

    Article  PubMed  CAS  Google Scholar 

  39. Persico, A. M., Schindler, C. W., O’Hare, B. F., Brannock, M. T., and Uhl, G. R. (1993) Mol. Brain Res. 20, 91–100.

    Article  PubMed  CAS  Google Scholar 

  40. Nye, H. E. and Nestler, E. J. (1996) Mol. Pharmacol. 49, 636–645.

    PubMed  CAS  Google Scholar 

  41. Hiroi, N., Brown, J. R., Haile, C. N., Ye, H., Greenberg, M. E., and Nestler, E. J. (1997) Proc. Natl. Acad. Sci. USA 94, 10397–10402.

    Article  PubMed  CAS  Google Scholar 

  42. Robinson, T. E. and Berridge, K. C. (1993) Brain Res. 18, 247–291.

    Article  CAS  Google Scholar 

  43. Koob, G. F. (1996) Neuron 16, 893–896.

    Article  PubMed  CAS  Google Scholar 

  44. Mumberg, D., Lucibello, E C., Schuermann, M., and Muller, R. (1991) Genes Dev. 5, 1212–1223.

    Article  PubMed  CAS  Google Scholar 

  45. Nakabeppu, Y. and Nathans, D. (1991) Cell 64, 751–759.

    Article  PubMed  CAS  Google Scholar 

  46. Abel, T., Martin, K. C., Bartsch, D., and Kandel, E. R. (1998) Science 279, 338–341.

    Article  PubMed  CAS  Google Scholar 

  47. Liu, J., Nickolenko, J., and Sharp, E R. (1994) Proc. Natl. Acad. Sci. USA 91, 8537–8541.

    Article  PubMed  CAS  Google Scholar 

  48. Couceyro, P. and Douglass, J. (1995) Mol. Pharmacol. 47, 29–39.

    PubMed  CAS  Google Scholar 

  49. Kosofsky, B. Geneva, L. M., and Hyman, S. E. (1995) J. Comp. Neurol. 351, 41–50.

    Article  Google Scholar 

  50. Wang, J. Q., Smith, A. J. W., and McGinty, J. F. (1995) Neurosci. 68, 83–95.

    Article  CAS  Google Scholar 

  51. Moratalla, R., Elibol, B., Vallejo, M., and Graybiel, A. M. (1996) Neuron 17, 147–156.

    Article  PubMed  CAS  Google Scholar 

  52. Couceyro, P., Pollock, K. M., Drews, K., and Douglass, J. (1994) Mol. Pharmacol. 46, 667–676.

    PubMed  CAS  Google Scholar 

  53. Moratalla, R., Vickers, E. A., Robertson, H. A., Cochran, B. H., and Graybiel, A. M. (1993) J. Neurosci. 13, 423–433.

    PubMed  CAS  Google Scholar 

  54. Chen, J. S., Nye, H. E., Kelz, M. B., Hiroi, N., Nakebeppu, Y., Hope, B. T., and Nestler, E. J. (1995) Mol. Pharmacol. 48, 880–889.

    PubMed  CAS  Google Scholar 

  55. Lepore, M., Liu, X., Savage, V., Matalon, D., and Gardner, E. L. (1996) Life Sci. 58, PL365—PL372.

    Google Scholar 

  56. Brodkin, T. and Nestler, E. J. (1998) The Neuroscientist, in press.

    Google Scholar 

Download references

Authors
  1. Noboru Hiroi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, New York University School of Medicine, USA

    Gabriel G. Nahas MD, PhD, DSc  & Kenneth M. Sutin MD, MS  & 

  2. Department of Biochemistry, Oxford University, USA

    David Harvey PhD

  3. Faculty of Pharmacy, University of Uppsala, Sweden

    Stig Agurell PhD, PharmD, DSc

  4. NYU School of Medicine, USA

    Nicholas Pace MD  & Robert Cancro MD  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Hiroi, N. (1999). Dependence, Tolerance, and Alteration in Gene Expression. In: Nahas, G.G., Sutin, K.M., Harvey, D., Agurell, S., Pace, N., Cancro, R. (eds) Marihuana and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-710-9_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-710-9_20

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5717-0

  • Online ISBN: 978-1-59259-710-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation