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Clinical Issues

Childhood Illnesses, Vaccinations, and Nutritional Status

  • Chapter
Nutrition and Immunology

Abstract

The concept that malnutrition conditions the response to infectious diseases was convincingly presented by Scrimshaw et al. in 1959 (1) and updated in a World Health Organization monograph in 1968. The mechanisms by which this interaction occurred were not understood, but they were thought to be mediated by an effect of nutrition on the immune system. Most of the data reviewed at the time came from animal studies because there were only a limited number of published human investigations that examined immunological functions. In addition, these studies focused primarily on the effects of malnutrition on antibody-mediated immunity because that was the best understood immune host defense. Of particular interest to us, looking back three decades later, is the virtual lack of any reference to the potential impact of malnutrition on lymphocytes or cell-mediated immune responses, reflecting the state of understanding of basic immunological mechanisms at the time. The immune system is now known to be a complex interaction of cells with cells and soluble regulatory factors leading to immune responses mediated by both activated cells and soluble factors; this is described in greater detail elsewhere in this text. It is the specific goal of this chapter to examine the implications of nutritionally mediated alterations in immune function on the clinical response to infectious agents and vaccines.

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Authors
  1. Noel W. Solomons
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  2. Gerald T. Keusch
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Editors and Affiliations

  1. Division of Rheumatology/Allergy and Clinical Immunology, Department of Internal Medicine, University of California at Davis, Davis, CA, USA

    M. Eric Gershwin MD

  2. Department of Food Science and Technology, University of California at Davis, Davis, CA, USA

    J. Bruce German PhD

  3. Department of Nutrition, University of California at Davis, Davis, CA, USA

    Carl L. Keen PhD

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© 2000 Springer Science+Business Media New York

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Solomons, N.W., Keusch, G.T. (2000). Clinical Issues. In: Gershwin, M.E., German, J.B., Keen, C.L. (eds) Nutrition and Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-709-3_15

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  • DOI: https://doi.org/10.1007/978-1-59259-709-3_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-148-6

  • Online ISBN: 978-1-59259-709-3

  • eBook Packages: Springer Book Archive

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