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Hormones and the Heart in Health and Disease pp 115–135Cite as

Insulin and the Heart

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Part of the book series: Contemporary Endocrinology ((COE,volume 21))

Abstract

This chapter outlines the aspects of heart function and metabolism that are modulated by insulin, and explores the biochemical mechanisms that account for the actions of the hormone. The actions of insulin on the heart must be viewed in the context of the constant and dynamic function of the organ, and also with respect to the complex set of endocrine, paracrine, and neural signals to which myocardial cells are exposed in vivo. The focus is on the metabolic responses, because these have been particularly well documented. The actions of insulin on heart metabolism have been established on the basis of studies in vitro with isolated cells or perfused tissue, as well as on clinical and experimental in vivo studies.

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Authors
  1. Roger W Brownsey
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  2. Brian Rodrigues
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  3. Subodh Verma
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  4. John H. McNeill
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Editors and Affiliations

  1. Department of Physiology, The University of Tennessee, Memphis, TN, USA

    Leonard Share PhD

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Brownsey, R.W., Rodrigues, B., Verma, S., McNeill, J.H. (1999). Insulin and the Heart. In: Share, L. (eds) Hormones and the Heart in Health and Disease. Contemporary Endocrinology, vol 21. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-708-6_8

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  • DOI: https://doi.org/10.1007/978-1-59259-708-6_8

  • Publisher Name: Humana Press, Totowa, NJ

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