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Adrenomedullin and the Heart

  • Chapter
Hormones and the Heart in Health and Disease

Part of the book series: Contemporary Endocrinology ((COE,volume 21))

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Abstract

Biologic assays employed for screening novel peptides, once sequenced, or even during initial purification attempts, have evolved over the years from whole-animal models to isolated tissue systems in perfusion chambers, and, most recently, to systems employing cultured mammalian cells. The end product of these most recent bioassay systems can be monitored on the basis of cell growth or division, hormone secretion, or even changes in intracellular signaling events. It was using just such a bioassay that Matsuo et al. (1), in 1993, isolated a novel vasoactive hormone, termed adrenomedullin (AM). The peptide stimulated platelet adenylyl cyclase activity, and then, in whole-animal bioassay, was found to be a potent vasodilator (1). This chapter describes the identification of the pharmacologic and physiologic properties of AM and its sibling pair, proadrenomedullin N-terminal 20 peptide (PAMP), with particular focus on production in, and the effects on, the cardiovascular system.

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Authors
  1. Willis K. Samson
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Editors and Affiliations

  1. Department of Physiology, The University of Tennessee, Memphis, TN, USA

    Leonard Share PhD

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© 1999 Springer Science+Business Media New York

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Samson, W.K. (1999). Adrenomedullin and the Heart. In: Share, L. (eds) Hormones and the Heart in Health and Disease. Contemporary Endocrinology, vol 21. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-708-6_2

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  • DOI: https://doi.org/10.1007/978-1-59259-708-6_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5420-9

  • Online ISBN: 978-1-59259-708-6

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