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Hormones and the Heart in Health and Disease pp 1–20Cite as

Natriuretic Peptides and the Heart

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Part of the book series: Contemporary Endocrinology ((COE,volume 21))

Abstract

In 1981 DeBold et al. (1) made a seminal observation that opened an entirely new field of investigation in cardiovascular research. They found that injection of atrial, but not ventricular, extracts into test animals resulted in a natriuretic diuresis and reduction in intravascular volume. This activity was originally termed atrial natriuretic factor, and later, atrial natriuretic peptide (ANP), following its isolation and characterization. ANP is a member of a family of peptides, each encoded by a different gene (Fig. 1). The sites of production of these peptides and, to some degree, their functional activity are typically unique for each member of the group. This chapter will focus on the molecular and cellular mechanisms that govern the production and activity of the natriuretic peptides (NP), with particular emphasis on the heart.

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Authors
  1. David G. Gardner
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  2. Branka Kovacic-Milivojevic
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  3. Faquan Liang
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  4. Songcang Chen
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Editors and Affiliations

  1. Department of Physiology, The University of Tennessee, Memphis, TN, USA

    Leonard Share PhD

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Gardner, D.G., Kovacic-Milivojevic, B., Liang, F., Chen, S. (1999). Natriuretic Peptides and the Heart. In: Share, L. (eds) Hormones and the Heart in Health and Disease. Contemporary Endocrinology, vol 21. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-708-6_1

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  • DOI: https://doi.org/10.1007/978-1-59259-708-6_1

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