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IL-8 in Animal Models of Disease

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Chemokines in Disease

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

Inflammatory reactions are characterized by dramatic movement of leukocytes and fluids from the bloodstream into the inflamed tissues. The classical chemotactic factors such as C5a, leukotriene B4 (LTB4), and platelet-activating factor (PAF) mediate the migration of all types of leukocytes. However, pathologically, it is well known that the types of infiltrating cells vary depending largely upon the stimuli and the interval from the injury. Neutrophils infiltrate at early phase of the inflammation and are hallmarks of acute inflammation, whereas macrophages, lymphocytes and plasma cells are main components of chronic inflammation that follows the acute inflammation if the causal stimuli are not removed. The existence of specific chemotactic factor for the selective recruitment of leukocytes has been postulated for a long time.

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Authors
  1. Akihisa Harada
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  2. Kouji Matsushima
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Editors and Affiliations

  1. Genentech, South San Francisco, CA, USA

    Caroline A. Hébert PhD (Senior Scientist) (Senior Scientist)

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Harada, A., Matsushima, K. (1999). IL-8 in Animal Models of Disease. In: Hébert, C.A. (eds) Chemokines in Disease. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-706-2_5

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  • DOI: https://doi.org/10.1007/978-1-59259-706-2_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4762-1

  • Online ISBN: 978-1-59259-706-2

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