Abstract
Beginning in the 1980s, investigators began to uncover a mammalian system of cell—cell communication that has developed into an entire field of research with implications for immunology, virology, neurobiology, developmental biology, and oncology. What began as a small number of inducible monocyte/macrophage and neutrophil chemo-attractants has grown to include molecules that may signal virtually all cells of the lymphoid and myeloid lineage, as well as endothelial cells, neurons, fibroblasts, and epithelial cells. In simplistic terms, it appears that nature operated on a protein motif that served as a template for the evolution of an entire gene family of ligands and receptors through gene duplication; the very organization of the ligands and receptors in the genome bears witness to this. It has been presumed that the selective advantage for the evolution of the chemokine/receptor system lies in the realm of host defense. However, the obviously critical role of several alpha chemokines and their receptors in developmental biology may lead to other interpretations, as will be discussed in a following section.
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Gerard, C. (1999). Understanding Chemokine Biology Through Mouse Genetics. In: Hébert, C.A. (eds) Chemokines in Disease. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-706-2_3
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DOI: https://doi.org/10.1007/978-1-59259-706-2_3
Publisher Name: Humana Press, Totowa, NJ
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