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The HIV Coreceptor Repertoire

All in the Family of Chemokine Receptors

  • Chapter
Chemokines in Disease

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

Within 1–3 years after the discovery of human immunodeficiency virus (HIV) as the causative agent of acquired immune deficiency syndrome (AIDS) (1,2), the CD4 molecule was identified as the primary HIV receptor (3). HIV was shown to enter target cells by an initial binding event between the envelope glycoprotein (Env) molecules on the viral membrane and CD4 molecules on the target cell surface, followed by direct, pH-independent membrane fusion. Yet as early as 1986, it became clear that the Env-CD4 interaction was not sufficient to promote the fusion reaction (4–6); several lines of evidence indicated that the target cell must contain an additional human-specific cofactor (7–11), presumably a “coreceptor.”

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  1. Edward A. Berger
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  1. Genentech, South San Francisco, CA, USA

    Caroline A. Hébert PhD (Senior Scientist) (Senior Scientist)

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Berger, E.A., Farber, J.M. (1999). The HIV Coreceptor Repertoire. In: Hébert, C.A. (eds) Chemokines in Disease. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-706-2_16

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