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Potential Roles for Chemokines in Transplant Rejection

  • Chapter
Chemokines in Disease

Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

Transplantation is the treatment of choice for patients with end-stage organ failure. Over the past two decades, the feasibility and scope of organ transplantation have been greatly expanded based on a number of developments including improvements in surgical techniques, more effective methods for graft preservation, and the introduction of novel immunosuppressive agents for clinical use (1). However, a number of hurdles and problems remain to be solved. For example, although 1-yr survival for renal transplants from cadaveric donors averages more than 80% nationwide, less than 50% of kidney grafts survive beyond 7 yr. In addition, the incidence of chronic rejection, manifested by coronary arteriosclerosis in heart transplants and obliterative bronchiolitis in lung transplants reaches 50% in 5 yr. (Statistics from the United Network for Organ Sharing, Richmond, VA http://204.127.237.11)

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Authors
  1. Ronald P. Gladue
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  2. Thomas M. Coffman
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Editors and Affiliations

  1. Genentech, South San Francisco, CA, USA

    Caroline A. Hébert PhD (Senior Scientist) (Senior Scientist)

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Gladue, R.P., Coffman, T.M. (1999). Potential Roles for Chemokines in Transplant Rejection. In: Hébert, C.A. (eds) Chemokines in Disease. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-706-2_11

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  • DOI: https://doi.org/10.1007/978-1-59259-706-2_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4762-1

  • Online ISBN: 978-1-59259-706-2

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