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Targeting Costimulatory and Other Signaling Molecules in Murine Lupus

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Lupus

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

Recent advances in the understanding of T-cell activation and effector func­tion have made it possible to consider novel strategies to treat diseases that are in part mediated by the immune system. Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by the production of autoantibodies that are deposited as immune complexes in the kidneys and other organs, and is associated with an inflammatory response. A number of T-cell abnormalities exist in patients with SLE and in mouse lupus models, which can contribute to the pro­gression of this autoimmune disorder. One method of treating SLE involves blocking T-cell function. Since activated T cells are already present in SLE, this would involve downregulation of effector T-cell activity as well as the inhibition of memory T-cell activation. Such treatment could abrogate the ongoing disease but may also cause generalized immunosuppression, increasing susceptibility to infections. Identifying treatments that block autoimmune disease but sustain immune competence will be an important goal in the development of future therapies.

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Authors
  1. Mark J. Halvorson
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  2. William C. Gause
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Editors and Affiliations

  1. Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Gary M. Kammer MD

  2. Division of Rheumatology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

  3. Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, USA

    George C. Tsokos MD

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Halvorson, M.J., Gause, W.C. (1999). Targeting Costimulatory and Other Signaling Molecules in Murine Lupus. In: Kammer, G.M., Tsokos, G.C. (eds) Lupus. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-703-1_39

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  • DOI: https://doi.org/10.1007/978-1-59259-703-1_39

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