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Lipids and Lupus

The Fats of the Matter

  • Chapter
Lupus

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

Treatment of patients with systemic lupus erythematosus (SLE) has improved owing to better management of severe manifestations such as renal failure, central nervous system disease, infection, and pulmonary hemorrhage. In addition, improved outcomes are the result of more judicious use of antiinflammatory drugs, addition of antimalarials, advances in surgical repair and replacement of joints damaged by osteonecrosis, and more appropriate use of corticosteroids and other drugs, such as cyclophosphamide and cyclosporine. Unfortunately, many of these therapies are associated with adverse effects that can be as difficult to manage as the disease itself. New ways to treat SLE patients are needed. This chapter explores the potential use of unsaturated fatty acids for treatment of SLE.

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References

  1. Burr, G. O. and Burr, M. M. (1930) On the nature and role of the fatty acids essential in nutrition. J. Biol. Chem. 86, 587–621.

    CAS  Google Scholar 

  2. Willis, A. L. (1981) Nutritional and pharmacological factors in eicosanoid biology. Nutr. Rev. 39, 289–301.

    Article  PubMed  CAS  Google Scholar 

  3. Hafstrom, I., Ringertz, B., Gyllenhammar, H., Palmblad, J., and Harms-Ringdatil, M. (1988) Effects of fasting on disease activity, neutrophil function, fatty acid composition and leukotriene biosynthesis in patients with rheumatoid arthritis. Arthritis Rheum. 31, 585–592.

    Article  PubMed  CAS  Google Scholar 

  4. Mustard, J. F., Packham, M. A., and Kinlough-Rathbone, R. L. (1988) The role of platelets in the early and late stages of atherosclerosis and its clinical complications. Prog. Clin. Biol. Res. 283, 639–672.

    PubMed  CAS  Google Scholar 

  5. Fischer, S. and Weber, P. C. (1985) Prostaglandin 13 is formed in vivo in man after dietary eicosapentaenoic acid. Nature 307, 165–168.

    Article  Google Scholar 

  6. Lee, T. H., Hoover, R. L., Williams, J. D., Sperling, R. I., Ravalese, J., Robinson, D. R., Corey, E. J., Lewis, R. A., and Austen, K. F. (1985) Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N. Engl. J. Med. 312, 1217–1224.

    Article  PubMed  CAS  Google Scholar 

  7. Sperling, R. I., Benincasso, A. I., Knoel, C. T., Larkin, J. K., Austen, K. F., and Robinson, D. R. (1993) Dietary n-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J. Clin. Invest. 91, 651–660.

    Article  PubMed  CAS  Google Scholar 

  8. Ziboh, V. A. and Chapkin, R. S. (1987) Biologic significance of polyunsaturated fatty acids in the skin. Arch. Dermatol. 123, 1686–1690.

    Article  Google Scholar 

  9. Baker, D. G., Krakauer, K. A., Tate, G., Laposata, M., and Zurier, R. B. (1989) Suppression of human synovial cell proliferation by dihomo-y-linolenic acid. Arthritis Rheum. 32, 1273–1281.

    Article  PubMed  CAS  Google Scholar 

  10. Vane, J. R. (1976) Protaglandins as mediators of inflammation, in Advances in Prostaglandin and Thromboxane Research, ( Samuelsson, B. and Paoletti, R., eds.), Raven Press, New York, pp. 791–798.

    Google Scholar 

  11. Fantone, J. C, Kunkel, S. L., and Zurier, R. B. (1985) Effects of prostaglandins on in vivo immune and inflammatory reactions, in Prostaglandins and Immunity, (Goodwin, J. S., ed.), Martinus Nijhoff, Boston, pp. 123–146.

    Google Scholar 

  12. Endres, S. (1993) Messengers and mediators: interactions among lipids, eicosanoids, and cytokines. Am. J. Clin. Nutr. 57, 7985–8005.

    Google Scholar 

  13. Hedqvist, P. (1970) Studies on the effects of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues. Acta Physiol. Scand. 345 (Suppl 79), 1–40.

    CAS  Google Scholar 

  14. Bygdeman, M. and Samuelson, B. (1964) Quantitative determination of prostaglandins in human semen. Clin. Chim. Acta 10, 566–568.

    Article  PubMed  CAS  Google Scholar 

  15. Karim, S. M. M., Soindler, M., and Williams, E. D. (1967) Distribution of prostaglandins in human tissues. Br. J. Pharmacol. Chemother. 31, 340–344.

    Article  PubMed  CAS  Google Scholar 

  16. Horrobin, D. F. (1988) The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetes mellitus. Prostaglandins, Leukotrienes, Essential Fatty Acids. 31, 181–197.

    CAS  Google Scholar 

  17. Holman, R. T., Smythe, L., and Johnson, S. (1979) Effect of sex and age on fatty acid composition of human serum lipids. Am. J. Clin. Nutr. 32, 2390–2399.

    PubMed  CAS  Google Scholar 

  18. Datta-Roy, A. K., Colman, R. W., and Sinha, A. K. (1983) Prostaglandin E1 and E2 receptors of human erythrocyte membranes. J. Cell. Biol. 97, 403–404.

    Google Scholar 

  19. Kloeze, J. (1969) Relationship between chemical structure and platelet aggregation activity of prostaglandins. Biochem. Biophys. Acta 187, 285–292.

    Article  PubMed  CAS  Google Scholar 

  20. Suzuki, T., Nakanishi, H., and Nakahata, N. (1982) Antagonism between prostaglandin E1 and PGE2 in bovine coronary arteries. Fukushima J. Med. Sci. 29, 111.

    Google Scholar 

  21. Kitson, G. E. and Pipkin, F. B. (1981) Effects of interactions of prostaglandins E1 and E2 on human chorionic plate arteries. Am. J. Obstet. Gynecol. 140, 683–692.

    PubMed  CAS  Google Scholar 

  22. Manevich, E. M., Lakin, K. M., and Archakov, A. I. (1985) Influence of cholesterol and prostaglandin E1 on the molecular organization of phospholipids in the erythrocyte membrane: a fluorescent polarization study with lipid specific probes. Biochim. Biophys. Acta 815, 455–460.

    Article  PubMed  CAS  Google Scholar 

  23. Tate, G., Mandell, B. F., Schumacher, H. R., and Zurier, R. B. (1988) Suppression of acute inflammation by 15 methyl prostaglandin E1. Lab. Invest. 59, 192–199.

    PubMed  CAS  Google Scholar 

  24. Krakauer, K. A., Torrey, S. B., and Zurier, R. B. (1978) Prostaglandin E1 treatment of NZB/W mice. III. Preservation of spleen cell concentrations and mitogen induced proliferative responses. Clin. Immunol. Immunopathol. 11, 256–262.

    Article  PubMed  CAS  Google Scholar 

  25. Whittum, J., Goldschneider, I., Greiner, D., and Zurier, R. B. (1985). Developmental abnormalities of terminal deoxynucleotidyl transferase positive bone marrow cells and thymocytes in New Zealand mice: effects of prostaglandin El. J. Immunol. 135, 272–280.

    PubMed  CAS  Google Scholar 

  26. Whittum-Hudson, J., Ballow, M., and Zurier, R. B. (1988) Effect of PGE1 treatment on in vitro thymocyte function of normal and autoimmune mice. Immunopharmacology 166, 71–78.

    Article  Google Scholar 

  27. Izui, S., Kelley, V. E., McConahey, A., and Dixon, F. J. (1981) Selective suppression of retroviral gp70-anti-gp70 immune complex formation by prostaglandin E1 in murine systemic lupus erythematosus. J. Exp. Med. 152, 1645–1658.

    Article  Google Scholar 

  28. Thompson, P. A., Jelinek, D. F., and Lipsky, P. E. (1984) Regulation of human B cell proliferation by PGE2. J. Immunol. 133, 2446–2450.

    PubMed  CAS  Google Scholar 

  29. Nagayama, Y., Manura, Y., Tamura, T., and Muso, R. (1988) Beneficial effect of prostaglandin E1 in three cases of lupus nephritis with nephrotic syndrome. Ann. Allergy 61, 289–295.

    PubMed  CAS  Google Scholar 

  30. Yoshikawa, T., Suzuki, H., Kato, H., and Yano, S. (1990) Effects of prostaglandin E1 on collagen diseases with high levels of circulating immune complexes. J. Rheumatol. 17, 1513–1524.

    PubMed  CAS  Google Scholar 

  31. Fantone, J. C., Kunkel, S. L., Ward, P. A., and Zurier, R. B. (1981) Suppression of human polymorphonuclear leucocyte function after intravenous infusion of prostaglandin El. Prostaglandins Med. 7, 195–198.

    Article  PubMed  CAS  Google Scholar 

  32. Goodwin, J. S. and Clay, G. A. (1986). Effect of chronic ingestion of a prostaglandin E analogue on immunologic function in healthy elderly subjects. Int. J. Immunopharmacol. 8, 867–875.

    Article  CAS  Google Scholar 

  33. McMurchie, E. J. (1988) Dietary lipids and the regulation of membrane fluidity and function, in Physiological Regulation of Membrane Fluidity, ( Aloid, R. C., Curtain, C. C., and Gordon, L. M., eds.), Alan R. Liss, New York, pp. 189–237.

    Google Scholar 

  34. Calder, P. C., Bevan, S. J., and Newsholme, E. A. (1992) The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism. Immunology 75, 108–115.

    PubMed  CAS  Google Scholar 

  35. Meydani, S. N., Endres, S., Woods, M. M., Goldin, B. R., Soo, C., Morrill-Labrode, A., Dinarello, C. A., and Gorbach, S. L. (1991) Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J. Nutr. 121, 547–555.

    PubMed  CAS  Google Scholar 

  36. Endres, S., Meydani, S. N., Ghorbani, S., Schindler, R., and Dinarello, C. A. (1993) Dietary supplementation with n-3 fatty acids suppresses interleukin-2 production and mononuclear cell proliferation. J. Leuk. Biol. 54, 599–603.

    CAS  Google Scholar 

  37. Payan, D. G., Wong, M. Y., Chernov-Rogan, T., Valone, F. H., Pickette, W. C., Blake, V. A., Gold, W. M., and Goetzl, E. J. (1986) Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid. J. Clin. Immunol. 6, 402–410.

    Article  PubMed  CAS  Google Scholar 

  38. Kremer, J. M., Laurence, D. L., Jubiz, W., DiGiacome, R., Rynes, R., and Bartholomew, L. E. (1990) Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis: clinical and immunological effects. Arthritis Rheum. 33 810–820.

    Google Scholar 

  39. Kelly, J. P. and Parker, C. W. (1979) Effects of arachidonic acid and other unsaturated fatty acids on mitogenesis in human lymphocytes. J. Immunol. 122, 1556–1562.

    PubMed  CAS  Google Scholar 

  40. Santoli, D. and Zurier, R. B. (1989) Prostaglandin E (PGE) precursor fatty acids inhibit human IL-2 production by PGE-independent mechanisms. J. Immunol. 143, 1303–1309.

    PubMed  CAS  Google Scholar 

  41. Santoli, D., Phillips, P. D., Colt, T. L., and Zurier, R. B. (1990) Suppression of interleukin-2 dependent human T cell growth by E Series prostaglandins (PGE) and their precursor fatty acids: evidence for a PGE-independent mechanism of inhibition by the fatty acids. J. Clin. Invest. 85, 424–432.

    Article  PubMed  CAS  Google Scholar 

  42. DeMarco, D. M., Santoli, D., and Zurier, R. B. (1994) Effects of fatty acids on proliferation and activation of human synovial compartment lymphocytes. J. Leuk. Biol. 56, 612–616.

    CAS  Google Scholar 

  43. Dayal, A. K. and Kammer, G. M. (1996) The T cell enigma in lupus. Arthritis Rheum. 39, 23–33.

    Article  PubMed  CAS  Google Scholar 

  44. Horwitz, D. A., Stohl, W., and Gray, J. D. (1997) T lymphocytes, natural killer cells, cytokines, and immune regulation, in Dubois’ Lupus Erythematosus, ( Wallace, D. J. and Hahn, B. H., eds.), Williams & Wilkins, Baltimore, pp. 155–194.

    Google Scholar 

  45. Theocharis, S., Sfikakis, P. P., Lipnick, R. N., Klipple, G. L., Steinberg, A. D., and Tsokos, G. C. (1995) Characterization of in vivo mutated T cell clones from patients with systemic lupus erythematosus. Clin. Immunol. Immunopathol. 74, 135–142.

    Article  PubMed  CAS  Google Scholar 

  46. Rossetti, R. G., De Luca, P., Seiler, C. M., Zurier, A. W., Karim, P., and Zurier, R. B. (1997) Modification of human lymphocyte and monoctye function by gammalinolenic acid (GLA), an unsaturated fatty acid: Studies in vitro and in vivo. Arthritis Rheum. 40, 8177 (abstract).

    Google Scholar 

  47. Rossetti, R. G., Seiler, C. M., DeLuca, P., Laposata, M., and Zurier, R. B. (1997) Oral administration of unsaturated fatty acids: Effects on human peripheral blood T lymphocyte proliferation. J. Leuk. Biol., 62, 438–443.

    CAS  Google Scholar 

  48. Scholz, W., Isakov, N., Mally, M., Theofilopoulos, A., and Altman, A. (1998) Lpr T cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis. J. Biol. Chem. 263, 3626–3631.

    Google Scholar 

  49. Rossetti, R. G., Seiler, C. M., Laposata, M., and Zurier, R. B. (1995) Differential regulation of human T lymphocyte protein kinase C activity by unsaturated fatty acids. Clin. Immunol. Immunopathol. 76, 220–224.

    Article  PubMed  CAS  Google Scholar 

  50. Liossis, S. N. C., Dennis, G., Kammer, G. M., and Tsokos, G. C. (1996) B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J. Clin. Invest. 98, 2549–2557.

    Article  PubMed  CAS  Google Scholar 

  51. Vassilopoulos, D., Zurier, R. B., Rossetti, R. G., and Tsokos, G. C. (1997) Gammalinolenic acid and dihomo-y-linolenic acid suppress CD3-mediated signal transduction pathway in human T cells. Clin. Immunol. Immunopathol. 83, 237–244.

    Article  PubMed  CAS  Google Scholar 

  52. Brennan, D. C., Wuthrich, R. P., Yui, M. A., and Kelley, V. R. (1989) TNF and IL-1 in NZB/W mice: enhanced gene expression and acceleration of renal injury. J. Immunol. 143, 3470–3475.

    PubMed  CAS  Google Scholar 

  53. Yokoyama, H., Burkhard, K., and Kelley, V. R. (1995) Biphasic increase in circulating and renal TNFa in MRL/lpr mice with differing regulatory mechanisms. Kidney Int. 47, 122–130.

    Article  PubMed  CAS  Google Scholar 

  54. Linker-Israel, M. (1992) Cytokine abnormalities in human lupus. Clin. Immunol. Immunopathol. 63, 10–12.

    Article  Google Scholar 

  55. Horn, J. T., Cole, H., and Bendele, A. M. (1990) Interleukin-1 enhances the development of spontaneous arthritis in MRL/lpr mice. Clin. Immunol. Immunopathol. 55, 109–119.

    Article  Google Scholar 

  56. Endres, S., Ghorbani, R., Kelley, V. E., Georgilis, K., Lonnemann, G., VanderMeer, J. W., Cannon, J. G., Rogers, T. S., Klempner, M. S., and Weber, P. C. (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N. Engl. J. Med. 320, 265–271.

    Article  PubMed  CAS  Google Scholar 

  57. Meydani, S. N., Lichtenstein, A. H., Cornwall, S., Meydani, M., Goldin, B. R., Rasmussen, H., Dinarello, C. A., and Schaefer, E. J. (1993) Immunological effects of National Cholesterol Education Panel Step-2 Diets with and without fish-derived n-3 fatty acid enrichment. J. Clin. Invest. 92, 105–113.

    Article  PubMed  CAS  Google Scholar 

  58. Robinson, D. R., Urakaze, M., Huang, R., Taki, H., Sugiyama, E., Knoell, C. T., Xu, L., Yeh, E. T. H., and Auron, P. (1996) Dietary marine lipids suppress continuous expression of interleukin-lß gene transcription. Lipids 31, 523–531.

    Article  Google Scholar 

  59. DeLuca, P., Rothman, D., and Zurier, R. B. (1995) Marine and botanical lipids as immunomodulatory and therapeutic agents in the treatment of rheumatoid arthritis. Rheum. Dis. Clin. North Amer. 21, 759–777.

    CAS  Google Scholar 

  60. DeLuca, P., Rossetti, R., and Zurier, R. B. (1996) Gammalinolenic acid reduces tumor necrosis factor a release from LPS-stimulated human peripheral blood mononuclear cells. J. Invest. Med. 4, 219A (abstract).

    Google Scholar 

  61. Kimberly, R. P., Gill, J. R., Bowden, R. E., Keiser, H. R., and Plotz, P. H. (1978) Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus. Ann. Intern. Med. 89, 336–341.

    Article  PubMed  CAS  Google Scholar 

  62. Spurney, R. F., Ruiz, P., Pisetsky, D. S., and.Coffman, T. M. (1991) Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites. Kidney Int. 39, 95–102.

    Article  PubMed  CAS  Google Scholar 

  63. Kremer, J. M. (1991) Clinical studies of omega-3 fatty acid supplementation in patients who have rheumatoid arthritis. Rheum. Dis. Clin. North Am. 17, 391–402.

    PubMed  CAS  Google Scholar 

  64. Lau, C. S., Morley, K. D., and Belch, J. J. (1993) Effects of fish oil supplementation on non-steroidal antiinflammatory drug requirement in patients with mild rheumatoid arthritis—a double-blind placebo controlled study. Br. J. Rheumatol. 32, 982–989.

    Article  PubMed  CAS  Google Scholar 

  65. Zurier, R. B., Rossetti, R. G., Jacobson, E. W., DeMarco, D. M., Liu, N. Y., Temming, J. E., White, B. M., and Laposata, M. (1996) Gammalinolenic acid treatment of rheumatoid arthritis: a randomized, placebo-controlled trial. Arthritis Rheum. 39, 1808–1817.

    Google Scholar 

  66. Robinson, D. R., Prickett, J. D., Makoul, G. T., Steinberg, A. D., and Colvin, R. B. (1986) Dietary fish oil reduces progression of established renal disease in NZBxNZW F1 mice and delays renal disease in BXSB and MRL/L strains. Arthritis Rheum. 29, 539–546.

    Article  PubMed  CAS  Google Scholar 

  67. Prickett, J. D., Trentham, D. E., and Robinson, D. R. (1984) Dietary fish oil augments the induction of arthritis in rats immunized with type II collagen. J. Immunol. 132, 725–729.

    PubMed  CAS  Google Scholar 

  68. Moore, G. F., Yarboro, C., Sebring, N., Robinson, D. R., and Steinberg, A. D. (1987) Eicosapentaenoic acid in the treatment of systemic lupus erythematosus. Arthritis Rheum. 30, 533 (abstract).

    Article  Google Scholar 

  69. Walton, A. J. E., Snaith, M. L., Locniskar, M., Cumberland, A. G., Morrow, W. J. W., and Isenberg, D. A. (1991) Dietary fish oil and the severity of symptoms in patients with systemic lupus erythematosus. Ann. Rheum. Dis. 50, 463–466.

    Article  PubMed  CAS  Google Scholar 

  70. Darlington, L. G. and Ramsey, N. W. (1987) Olive oil for rheumatoid arthritis? Br. J. Rheum. 26, 215–217.

    Google Scholar 

  71. Godfrey, D. C., Stimson, W. H., Watson, J., Belch, J. J. F., and Sturrock, R. D. (1986) The modulation of autoimmunity in the MRL/lpr mouse by dietary fatty acid supplementation. Prog. Lipid Res. 25, 289–293.

    Google Scholar 

  72. Zurier, R. B. (1993) Fatty acids, inflammation, and immune responses. Prostaglandins, Leukotrienes, Essential Fatty Acids 48, 57–62.

    Article  CAS  Google Scholar 

  73. Freundlich, B., Shoback, B. R., and Zurier, R. B. (1985) Prostaglandin E generation by monocytes from SLE patients. Arthritis Rheum. 28, S48 (abstract).

    Google Scholar 

  74. Kariko, K., Rosenbaum, H., Kuo, A., Zurier, R. B., and Barnathan, E. S. (1995) Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 in cultured human endothelial cells. FEBS Lett. 361, 118–122.

    Google Scholar 

  75. Bunning, R. A. D., Elford, P. R., Meats, J. E., Richardson, H. J., and Russell, R. G. G. (1985) The effect of IL-1 on plasminogen activators producd by human chondrocytes. Br. J. Rheum. 24, 118–121.

    Google Scholar 

  76. Leventhal, L. J., Boyce, E. G., and Zurier, R. B. (1994) Treatment of rheumatoid arthritis with black currant seed oil. Br. J. Rheum. 33, 847–852.

    Article  CAS  Google Scholar 

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Authors
  1. Robert B. Zurier
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Editors and Affiliations

  1. Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Gary M. Kammer MD

  2. Division of Rheumatology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

  3. Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, USA

    George C. Tsokos MD

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Zurier, R.B. (1999). Lipids and Lupus. In: Kammer, G.M., Tsokos, G.C. (eds) Lupus. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-703-1_36

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  • DOI: https://doi.org/10.1007/978-1-59259-703-1_36

  • Publisher Name: Humana Press, Totowa, NJ

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