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Nitric Oxide in Systemic Lupus Erythematosus

Implications for Immunity and Inflammation

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Lupus

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

Recent studies have established that excessive nitric oxide (NO) is produced during the course of both the human and the MRL/lpr model of systemic lupus erythematosus (SLE) (1–6). Although the inhibition of NO synthesis improves outcome in the MRL/lpr mice, the role of NO in the pathogenesis of SLE is as yet undetermined. The biology of NO, produced by constitutive or induced enzymes in virtually all tissues, is likely to exert complex actions on both immunologic and inflammatory processes. This chapter reviews the data that indicate that NO might play an important role in SLE. There is an emphasis on the biological reactivity of NO as well as its effects on cells of inflammation and immunity. An understanding of the pleiotropic effects of NO could advance our understanding of the pathogenesis of SLE and possibly lead to novel therapeutic strategies.

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Authors
  1. H. Michael Belmont
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  2. Ashok R. Amin
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  3. Steven B. Abramson
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Editor information

Editors and Affiliations

  1. Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Gary M. Kammer MD

  2. Division of Rheumatology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

  3. Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, USA

    George C. Tsokos MD

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© 1999 Springer Science+Business Media New York

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Belmont, H.M., Amin, A.R., Abramson, S.B. (1999). Nitric Oxide in Systemic Lupus Erythematosus. In: Kammer, G.M., Tsokos, G.C. (eds) Lupus. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-703-1_3

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  • DOI: https://doi.org/10.1007/978-1-59259-703-1_3

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5686-9

  • Online ISBN: 978-1-59259-703-1

  • eBook Packages: Springer Book Archive

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