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Tumor Infiltration by Monocytes and the Antitumor Effects of Monocyte Chemoattractant Protein-1

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Chemokines and Cancer

Part of the book series: Contemporary Cancer Research ((CCR))

Abstract

Mononuclear cell infiltration is a common feature of many types of human cancers. In fact, its occurrence is considered so unremarkable that there are no systematic studies describing the prevalence or intensity of infiltrates by tumor type or stage. Instead, it is generally asserted that intense infiltrates are associated with certain tumor types, such as medullary carcinoma of the breast and malignant melanoma (1,2), and that most other cancers are also infiltrated to differing extents. Even without an “epidemiology” of tumor-related inflammatory infiltrates, tumor biologists have extensively focused on this phenomenon for more than 100 yr.

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  1. Barrett J. Rollins
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  2. Howard A. Fine
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  3. Long Gu
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  4. Kenzo Soejima
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  5. Susan Tseng
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Editors and Affiliations

  1. Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

    Barrett J. Rollins MD, PhD

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Rollins, B.J., Fine, H.A., Gu, L., Soejima, K., Tseng, S. (1999). Tumor Infiltration by Monocytes and the Antitumor Effects of Monocyte Chemoattractant Protein-1. In: Rollins, B.J. (eds) Chemokines and Cancer. Contemporary Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-701-7_6

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