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Tumors as a Paradigm for the In Vivo Role of Chemokines in Leukocyte Recruitment

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Chemokines and Cancer

Part of the book series: Contemporary Cancer Research ((CCR))

Abstract

Ever since the first description by Virchow in 1863, histopathologists have recognized the occurrence of host leukocytes in tumor tissues and/or at their periphery. Interestingly, Virchow felt that the frequent presence of a lymphoreticular infiltrate in human neoplasms reflected the origin of cancer at sites of previous chronic inflammation. In 1907 Hardley reported that normal cell infiltration in malignant melanoma indicated a “regressive process.” This observation marked a complete change in the general opinion as to the significance of the “lymphoreticular infiltrate,” a change reflected by a number of reports on pathology and prognosis. These opposite ways of looking at the relationship between leukocyte infiltration and malignancy have polarized views in the field but, indeed, reflect the pleiotropic, ambivalent functions of infiltrating cells.

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References

  1. Adams, D. O., and R. Snyderman. 1979. Do macrophages destroy nascent tumors? J. Natl. Cancer Inst. 62: 1341–1745.

    PubMed  CAS  Google Scholar 

  2. Allavena, P., M. Grandi, M. D'Incalci, O. Geri, F. C. Giuliani, and A. Mantovani. 1987. Human tumor cell lines with pleiotropic drug resistance are efficiently killed by interleukin-2 activated killer cells and by activated monocytes. Int. J. Cancer 40: 104–107.

    Article  PubMed  CAS  Google Scholar 

  3. Allavena, P., F. Peccatori, D. Maggioni, A. Erroi, M. Sironi, N. Colombo, A. Lissoni, A. Galazka, W. Meiers, C. Mangioni, and A. Mantovani. 1990. Intraperitoneal recombinant gamma-interferon in patients with recurrent ascitic ovarian carcinoma: modulation of cytotoxicity and cytokine production in tumor-associated effectors and of major histocompatibility antigen expression on tumor cells. Cancer Res. 50: 7318–7323.

    Google Scholar 

  4. Angiolillo, A. L., C. Sgadari, D. D. Taub, F. Liao, J. M. Farber, S. Maheshwari, H. K. Kleinman, G. H. Reaman, and G. Tosato. 1995. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182: 155–162.

    Article  PubMed  CAS  Google Scholar 

  5. Arenberg, D. A., S. L. Kunkel, P. J. Polverini, S. B. Morris, M. D. Burdick, M. C. Glass, D. T. Taub, M. D. lannettoni, T. I. Whyte, and R. M. Strieter. 1996. Interferon-gammainducible protein 10 (IPA 0) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases. J. Exp. Med. 184: 981–992.

    Article  PubMed  CAS  Google Scholar 

  6. Arvanitakis, L., E. GerasRaaka, A. Varma, M. C. Gershengorn, and E. Cesarman. 1997. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 385: 347–350.

    Article  PubMed  CAS  Google Scholar 

  7. Asano, T., T. An, S. F. Jia, and E. S. Kleinerman. 1996. Altered monocyte chemotactic and activating factor gene expression in human glioblastoma cell lines increased their susceptibility to cytotoxicity. J. Leukocyte Biol. 59: 916–924.

    PubMed  CAS  Google Scholar 

  8. Balentien, E., B. E. Mufson, R. L. Shattuck, R. Derynck, and A. Richmond. 1991. Effects of MGSA/GRO alpha on melanocyte transformation. Oncogene 6: 1115–1124.

    PubMed  CAS  Google Scholar 

  9. Bancherau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245–252.

    Google Scholar 

  10. Boechter, D., and E. J. Leonard. 1974. Abnormal monocyte chemotactic response in mice. J. Natl. Cancer Inst. 52: 1091–1099.

    Google Scholar 

  11. Bonecchi, R., G. Bianchi, P. Panina Bordignon, D. D'Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A. Mantovani, and F. Sinigaglia. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of Thl and Th2 cells. J. Exp. Med. 187: 129–134.

    Article  PubMed  CAS  Google Scholar 

  12. Bottazzi, B., P. Ghezzi, G. Taraboletti, M. Salmona, N. Colombo, C. Bonazzi, C. Mangioni, and A. Mantovani. 1985. Tumor-derived chemotactic factor(s) from human ovarian carcinoma: evidence for a role in the regulation of macrophage content of neoplastic tissues. Int. J. Cancer 36: 167–173.

    Article  PubMed  CAS  Google Scholar 

  13. Bottazzi, B., N. Polentarutti, R. Acero, A. Balsari, D. Boraschi, P. Ghezzi, M. Salmona, and A. Mantovani. 1983. Regulation of the macrophage content of neoplasms by chemoattractants. Science 220: 210–212.

    Article  PubMed  CAS  Google Scholar 

  14. Bottazzi, B., N. Polentarutti, A. Balsari, D. Boraschi, P. Ghezzi, M. Salmona, and A. Mantovani. 1983. Chemotactic activity for mononuclear phagocytes of culture supernatants from murine and human tumor cells: evidence for a role in the regulation of the macrophage content of neoplastic tissues. Int. J. Cancer 31: 55–63.

    Article  PubMed  CAS  Google Scholar 

  15. Bottazzi, B., S. Walter, D. Govoni, F. Colotta, and A. Mantovani. 1992. Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma. J. Immunol. 148: 1280–1285.

    PubMed  CAS  Google Scholar 

  16. Bucana, C. D., A. Fabra, R. Sanchez, and I. G. Fidler. 1992. Different patterns of macrophage infiltration into allogeneic-murine and xenogeneic-human neoplasms growing in nude mice. Am. J. Pathol. 141: 1225–1236.

    Google Scholar 

  17. Burke, F., M. Relf, R. Negus, and F. Balkwill. 1996. A cytokine profile of normal and malignant ovary. Cytokine 8: 578–585.

    Article  PubMed  CAS  Google Scholar 

  18. Cao, Y. H., C. Chen, J. A. Weatherbee, M. Tsang, J. Folkman. 1995. gro-beta, a -C-X-Cchemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice. J. Exp. Med. 182: 2069–2077.

    Google Scholar 

  19. Caux, C., Y. J. Liu, and J. Banchereau. 1995. Recent advances in the study of dendritic cells and follicular dendritic cells. Immunol. Today 16: 2–4.

    Article  PubMed  CAS  Google Scholar 

  20. Cianciolo, G. J., J. Hunter, J. Silva, J. S. Haskill, and R. Snyderman. 1981 Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses. J. Clin. Invest. 68: 831–844.

    Article  PubMed  CAS  Google Scholar 

  21. Clauss, M., M. Gerlach, H. Gerlach, J. Brett, F. Wang, P. C. Familletti, Y. C. Pan, J. V. Olander, D. T. Connolly, and D. Stern. 1990. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 172: 1535–1545.

    Article  PubMed  CAS  Google Scholar 

  22. Colombo, N., F. Peccatori, C. Paganin, S. Bini, M. Brandely, C. Mangioni, A. Mantovani, and P. Allavena. 1992. Anti-tumor and immunomodulatory activity of intraperitoneal IFNgamma in ovarian carcinoma patients with minimal residual tumor after chemotherapy. Int. J. Cancer 51: 42–46.

    Article  PubMed  CAS  Google Scholar 

  23. Colotta, F., S. Orlando, E. J. Fadlon, S. Sozzani, C. Matteucci, and A. Mantovani. 1995. Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells. J. Exp. Med. 181: 2181–2188.

    Article  PubMed  CAS  Google Scholar 

  24. DiNapoli, M. R., C. L. Calderon, and D. M. Lopez. 1996. The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduced expression of the inducible nitric oxide synthase gene. J. Exp. Med. 183: 1323–1329.

    Article  PubMed  CAS  Google Scholar 

  25. Dvorak, H. F. 1986. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315: 1650–1659.

    Article  PubMed  CAS  Google Scholar 

  26. Evans, R. 1972. Macrophages in syngeneic animal tumours. Transplantation 14: 468–470.

    Article  PubMed  CAS  Google Scholar 

  27. Fioretti, F., D. Fradelizi, A. Stoppacciaro, L. Ruco, A. Minty, S. Sozzani, A. Vecchi, and A. Mantovani. 1998. Reduced tumorigenicity and augmented leukocyte infiltration after MCP-3 gene transfer: perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor. J. Immunol. 161: 342–346.

    PubMed  CAS  Google Scholar 

  28. Godiska, R., D. Chantry, C. J. Raport, S. Sozzani, P. Allavena, D. Leviten, A. Mantovani, and P. W. Gray. 1997. Human macrophage derived chemokine (MDC)-a novel chemoattractant for monocytes, monocyte derived dendritic cells, and natural killer cells. J. Exp. Med. 185: 1595–1604.

    Article  PubMed  CAS  Google Scholar 

  29. Graves, D. T., R. Barnhill, T. Galanopoulos, and H. N. Antoniades. 1992. Expression of monocyte chemotactic protein-1 in human melanoma in vivo. Am. J. Pathol. 140: 9–14.

    PubMed  CAS  Google Scholar 

  30. Graves, D. T., Y. L. Jiang, M. J. Williamson, and A. J. Valente. 1989. Identification of monocyte chemotactic activity produced by malignant cells. Science 245: 1490–1493.

    Article  PubMed  CAS  Google Scholar 

  31. Greaves, D. R., W. Wang, D. J. Dairaghi, M. C. Dieu, B. de Saint-Vis, K. Franz-Bacon, D. Rossi, C. Caux, T. McClanahan, S. Gordon, A. Zlotnik, and T. J. Schall. 1997. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3 alpha and is highly expressed in human dendritic cells. J. Exp. Med. 186: 837–844.

    Article  PubMed  CAS  Google Scholar 

  32. Halimann, R., D. N. Mayer, E. L. Berg, R. Broermann, and E. C. Butcher. 1995. Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier. Dev. Dynamics 202: 325–332.

    Article  Google Scholar 

  33. Hechtman, D. H., M. I. Cybulsky, H. J. Fuchs, J. B. Baker, and M. A. J. Gimbrone. 1991. Intravascular IL-8: inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J. Immunol. 147: 883–892.

    PubMed  CAS  Google Scholar 

  34. Heuff, G., M. B. van der Ende, H. Boutkan, W. Prevoo, L. G. Bayon, G. J. Fleuren, R. H. Beelen, S. Meijer, and C. D. Dijkstra. 1993. Macrophage populations in different stages of induced hepatic metastases in rats: an immunohistochemical analysis. Scand. J. Immunol. 38: 10–16.

    Article  PubMed  CAS  Google Scholar 

  35. Hibbs, J. B. 1976. The macrophage as a tumoricidal effector cell: a review of in vivo and in vitro studies on the mechanism of the activated macrophage nonspecific cytotoxicity reaction. In: The macrophage and neoplasia ( M. A. Fink, ed.), Academic Press, New York, pp. 83–98.

    Google Scholar 

  36. Hirose, K., M. Hakozaki, Y. Nyunoya, Y. Kobayashi, K. Matsushita, T. Takenouchi, A. Mikata, N. Mukaida, and K. Matsushima. 1995. Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration. Br. J. Cancer 72: 708–714.

    Article  PubMed  CAS  Google Scholar 

  37. Jiang, Y., D. I. Beller, G. Frendl, and D. T. Graves. 1992. Monocyte chemoattractant protein-1 regulates adhesion molecule expression and cytokine production in human monocytes. J. Immunol. 148: 2423–2428.

    PubMed  CAS  Google Scholar 

  38. Koch, A. E., P. J. Polverini, S. L. Kunkel, L. A. Harlow, L. A. DiPietro, V. M. Elner, S. G. Elner, and R. M. Strieter. 1992. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258: 1798–1801.

    Article  PubMed  CAS  Google Scholar 

  39. Laning, J., H. Kawasaki, E. Tanaka, Y. Luo, and M. E. Dorf. 1994 Inhibition of in vivo tumor growth by the beta chemokine, TCA3. J. Immunol. 153: 4625–4635.

    PubMed  CAS  Google Scholar 

  40. Luster, A. D., S. M. Greenberg, and P. Leder. 1995. The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J. Exp. Med. 182: 219–231.

    Article  PubMed  CAS  Google Scholar 

  41. Luster, A. D., and P. Leder. 1993. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J. Exp. Med. 178: 1057–1065.

    Article  PubMed  CAS  Google Scholar 

  42. Manome, Y., P. Y. Wen, A. Hershowitz, T. Tanaka, B. J. Rollins, D. W. Kufe, and H. A. Fine. 1995. Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors. Cancer Immunol. Immunother. 41: 227–235.

    Article  PubMed  CAS  Google Scholar 

  43. Mantovani, A. 1994. Tumor-associated macrophages in neoplastic progression: a paradigm for the in vivo function of chemokines. Lab Invest. 71: 5–16.

    PubMed  CAS  Google Scholar 

  44. Mantovani, A., B. Bottazzi, F. Colotta, S. Sozzani, and L. Ruco. 1992. The origin and function of tumor-associated macrophages. Immunol. Today 13: 265–270.

    Article  PubMed  CAS  Google Scholar 

  45. Mantovani, A., B. Bottazzi, S. Sozzani, G. Peri, P. Allavena, Q. G. Dong, A. Vecchi, and F. Collotta. 1993. Cytokine regulation of tumour-associated macrophages. Res. Immunol. 144: 280–283.

    Article  PubMed  CAS  Google Scholar 

  46. Mantovani, A., F. Bussolino, and E. Dejana. 1992. Cytokine regulation of endothelial cell function. FASEB J. 6: 2591–2599.

    PubMed  CAS  Google Scholar 

  47. Mantovani, A., S. Sozzani, B. Bottazzi, G. Peri, F. L. Sciacca, M. Locati, and F. Colotta. 1993. Monocyte chemotactic protein-1 (MCP-1): signal transduction and involvement in the regulation of macrophage traffic in normal and neoplastic tissues. Adv. Exp. Med. Biol. 351: 47–54.

    Article  PubMed  CAS  Google Scholar 

  48. Medrano, E. E., J. Z. Farooqui, R. E. Boissy, Y. L. Boissy, B. Akadiri, and J. J. Nordlund. 1993. Chronic growth stimulation of human adult melanocytes by inflammatory mediators in vitro: implications for nevus formation and initial steps in melanocyte oncogenesis. Proc. Natl. Acad. Sci. USA 90: 1790–1794.

    Article  PubMed  CAS  Google Scholar 

  49. Melani, C., S. M. Pupa, A. Stoppacciaro, S. Menard, M. I. Colnaghi, G. Parmiani, and M. P. Colombo. 1995. An in vivo model to compare human leukocyte infiltration in carcinoma xenografts producing different chemokines. Int. J. Cancer 62: 572–578.

    Article  PubMed  CAS  Google Scholar 

  50. Mintz, B., and W. K. Silvers. 1993. Transgenic mouse model of malignant skin melanoma. Proc. Natl. Acad. Sci. USA 90: 8817–8821.

    Article  PubMed  CAS  Google Scholar 

  51. Mulé, J. J., M. Custer, B. Averbook, J. C. Yang, J. S. Weber, D. V. Goeddel, S. A. Rosenberg, and T. J. Schall. 1996. RANTES secretion by gene-modified tumor cells results in loss of tumorigenicity in vivo: role of immune cell subpopulations. Hum. Gene Ther. 7: 1545–1553.

    Google Scholar 

  52. Musiani, P., A. Modesti, M. Giovarelli, F. Cavallo, M. P. Colombo, P. L. Lollini, and G. Forni. 1997. Cytokines, tumor-cell death and immunogenicity: a question of choice. Immunol. Today 18: 32–36.

    Article  PubMed  CAS  Google Scholar 

  53. Nakamura, K., I. R. Williams, and T. S. Kupper. 1995. Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and langerhans cells to skin. J. Invest. Dermatol. 105: 635–643.

    Article  PubMed  CAS  Google Scholar 

  54. Negus, R. P., G. W. Stamp, M. G. Relf, F. Burke, S. T. Malik, S. Bernasconi, P. Allavena, S. Sozzani, A. Mantovani, and F. R. Balkwill. 1995. The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J. Clin Invest. 95: 2391–2396.

    Article  PubMed  CAS  Google Scholar 

  55. Normann, S. J., M. Schardt, and E. Sorkin. 1981. Biphasic depression of macrophage function after tumor transplantation. Int. J. Cancer 28: 185–190.

    Article  PubMed  CAS  Google Scholar 

  56. Normann, S. J., and E. Sorkin. 1976. Cell-specific defect in monocyte function during tumor growth. J. Natl. Cancer Inst. 57: 135–140.

    Google Scholar 

  57. Normann, S. J., and E. Sorkin. 1977. Inhibition of macrophage chemotaxis by neoplastic and other rapidly proliferating cells in vitro. Cancer Res. 37: 705–711.

    PubMed  CAS  Google Scholar 

  58. Opdenakker, G., G. Froyen, P. Fiten, P. Proost, and J. Van Damme. 1993. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. Biochem. Biophys. Res. Commun. 191: 535–542.

    Article  PubMed  CAS  Google Scholar 

  59. Opdenakker, G., and J. Van Damme. 1992. Chemotactic factors, passive invasion and metastasis of cancer cells. Immunol. Today 13: 463–464.

    Article  PubMed  CAS  Google Scholar 

  60. Opdenakker, G., and J. Van Damme. 1992. Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 4: 251–258.

    Article  PubMed  CAS  Google Scholar 

  61. Pardoll, D. M. 1995. Paracrine cytokine adjuvants in cancer immunotherapy. Annu. Rev. Immunol. 13: 399–415.

    Article  PubMed  CAS  Google Scholar 

  62. Peiper, S. C., Z. X. Wang, K. Neote, A. W. Martin, H. J. Showell, M. J. Conklyn, K. Ogborne, T. J. Hadley, Z. H. Lu, J. Hesselgesser, and R. Horuk. 1995. The Duffy antigen receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor. J. Exp. Med. 181: 1311–1317.

    Article  PubMed  CAS  Google Scholar 

  63. Pekarek, L. A., B. A. Starr, A. Y. Toledano, and H. Schreiber. 1995. Inhibition of tumor growth by elimination of granulocytes. J. Exp. Med. 181: 435–440.

    Article  PubMed  CAS  Google Scholar 

  64. Petzelbauer, P., C. A. Watson, S. E. Pfau, and J. S. Pober. 1995. IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro. Cytokine 7: 267–272.

    Article  PubMed  CAS  Google Scholar 

  65. Piemonti, L., S. Bernasconi, W. Luini, Z. Trobonjaca, A. Minty, P. Allavena, and A. Mantovani. 1995. IL-13 supports differentiation of dendritic cells from circulating precursors in concert with GM-CSF. Eur. Cytokine Network 6: 245–252.

    CAS  Google Scholar 

  66. Porteu, F., and C. Nathan. 1990. Shedding of tumor necrosis factor receptor by activated human neutrophils. J. Exp. Med. 172: 599–607.

    Article  PubMed  CAS  Google Scholar 

  67. Power, C. A., D. J. Church, A. Meyer, S. Alouani, A. E. I. Proudfoot, I. Clark-Lewis, S. Sozzani, A. Mantovani, and T. N. C. Wells. 1997. Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3 alpha from lung dendritic cells. J. Exp. Med. 186: 825–835.

    Article  PubMed  CAS  Google Scholar 

  68. Proost, P., C. De Wolf Peeters, R. Conings, G. Opdenakker, A. Billiau, and J. Van Damme. 1993. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells: in vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. J. Immunol. 150: 1000–1010.

    PubMed  CAS  Google Scholar 

  69. Riethdorf, L., S. Riethdorf, K. Gutzlaff, F. Prall, and T. Loning. 1996. Differential expression of the monocyte chemoattractant protein-1 gene in human papillomavirus-16-infected squamous intraepithelial lesions and squamous cell carcinomas of the cervix uteri. Am. J. Pathol. 149: 1469–1476.

    Google Scholar 

  70. Rojas, A., R. Delgado, L. Glaria, and M. Palacios. 1993. Monocyte chemotactic protein-1 inhibits the induction of nitric oxide synthase in J774 cells. Biochem. Biophys. Res. Commun. 196: 274–279.

    Article  PubMed  CAS  Google Scholar 

  71. Rollins, B. J., and M. E. Sunday. 1991. Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. Mol. Cell. Biol. 11: 3125–3131.

    PubMed  CAS  Google Scholar 

  72. Rot, A. 1992. Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration. Immunol. Today 13: 291–294.

    Article  PubMed  CAS  Google Scholar 

  73. Rutledge, B. J., H. Rayburn, R. Rosenberg, R. J. North, R. P. Gladue, C. L. Corless, and B. J. Rollins. 1995. High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. J. Immunol. 155: 4838–4843.

    PubMed  CAS  Google Scholar 

  74. Sakamoto, K., T. Masuda, S. Mita, T. Ishiko, Y. Nakashima, H. Arakawa, H. Egami, S. Harada, K. Matsushima, and M. Ogawa. 1992. Interleukin-8 is constitutively and commonly produced by various human carcinoma cell lines. Int. J. Clin. Lab. Res. 22: 216–219.

    Article  PubMed  CAS  Google Scholar 

  75. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin-4 and downregulated by tumor necrosis factor-alpa. J. Exp. Med. 179: 1109–1118.

    Article  PubMed  CAS  Google Scholar 

  76. Schadendorf, D., A. Moller, B. Algermissen, M. Worm, M. Sticherling, and B. M. Czarnetzki. 1993. IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor. J. Immunol. 151: 2667–2675.

    PubMed  CAS  Google Scholar 

  77. Schonbeck, U., E. Brandt, F. Petersen, H. D. Flad, and H. Loppnow. 1995. IL-8 specifically binds to endothelial but not to smooth muscle cells. J. Immunol. 154: 2375–2383.

    PubMed  CAS  Google Scholar 

  78. Sciacca, F. L., M. Stürzl, F. Bussolino, M. Sironi, H. Brandstetter, C. Zietz, D. Zhou, C. Matteucci, G. Peri, S. Sozzani, R. Benelli, M. Arese, A. Albini, F. Colotta, and A. Mantovani. 1994. Expression of adhesion molecules, platelet-activating factor, and chemokines by Kaposi's sarcoma cells. J. Immunol. 153: 4816–4825.

    PubMed  CAS  Google Scholar 

  79. Singh, R. K., K. Berry, K. Matsushima, K. Yasumoto, and I. J. Fidler. 1993. Synergism between human monocyte chemotactic and activating factor and bacterial products for activation of tumoricidal properties in murine macrophages. J. Immunol. 151: 2786–2793.

    PubMed  CAS  Google Scholar 

  80. Smith, D. R., P. J. Polverini, S. L. Kunkel, M. B. Orringer, R. I. Whyte, M. D. Burdick, C. A. Wilke, and R. M. Strieter. 1994 Inhibition of IL-8 attenuates angiogenesis in bronchogenic carcinoma. J. Exp. Med. 179: 1409–1415.

    Article  PubMed  CAS  Google Scholar 

  81. Snyderman, R., and G. J. Cianciolo. 1984 Immunosuppressive activity of the retroviral envelope protein P1 5E and its possible relationship to neoplasia. Immunol. Today 5: 240–244.

    Article  CAS  Google Scholar 

  82. Snyderman, R., and M. C. Pike. 1976. An inhibitor of macrophage chemotaxis produced by neoplasms. Science 192: 370–372.

    Article  PubMed  CAS  Google Scholar 

  83. Sonouchi, K., T. A. Hamilton, C. S. Tannenbaum, R. R. Tubbs, R. Bukowski, and J. H. Finke. 1994. Chemokine gene expression in the murine renal cell carcinoma, renca, following treatment in vivo with interferon-alpha and interleukin-2. Am. J. Pathol. 144: 747–755.

    PubMed  CAS  Google Scholar 

  84. Sozzani, S., W. Luini, A. Borsatti, N. Polentarutti, D. Zhou, L. Piemonti, G. D'Amico, C. A. Power, T. N. Wells, M. Gobbi, P. Allavena, and A. Mantovani. 1997. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J. Immunol. 159: 1993–2000.

    PubMed  CAS  Google Scholar 

  85. Sozzani, S., F. Sallusto, W. Luini, D. Zhou, L. Piemonti, P. Allavena, J. Van Damme, S. Valitutti, A. Lanzavecchia, and A. Mantovani. 1995. Migration of dendritic cells in response to formyl peptides, C5a and a distinct set of chemokines. J. Immunol. 155: 3292–3295.

    Google Scholar 

  86. Stevenson, M. M., and M. S. Meltzer. 1976. Depressed chemotactic responses in vitro of peritoneal macrophages from tumor-bearing mice. J. Natl. Cancer Inst. 57: 847–852.

    PubMed  CAS  Google Scholar 

  87. Strieter, R. M., P. J. Polverini, S. L. Kunkel, D. A. Arenberg, M. D. Burdick, J. Kasper, J. Dzuiba, J. Van Damme, A. Walz, D. Marriott, S. Y. Chan, S. Roczniak, and A. B. Shanafelt. 1995. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 270: 27,348–27, 357.

    Google Scholar 

  88. Takeya, M., T. Yoshimura, E. J. Leonard, T. Kato, H. Okabe, and K. Takahashi. 1991. Production of monocyte chemoattractant protein-1 by malignant fibrous histiocytoma: relation to the origin of histiocyte-like cells. Exp. Mol. Pathol. 54: 61–71.

    Article  PubMed  CAS  Google Scholar 

  89. Tannenbaum, C. S., N. Wicker, D. Armstrong, R. Tubbs, J. Finke, R. M. Bukowski, and T. A. Hamilton. 1996. Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12. J. Immunol. 156: 693–699.

    PubMed  CAS  Google Scholar 

  90. Van Damme, J., P. Proost, J. P. Lenaerts, and G. Opdenakker. 1992. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. J. Exp. Med. 176: 59–65.

    Article  PubMed  CAS  Google Scholar 

  91. Van Meir, E., M. Ceska, F. Effenberger, A. Walz, E. Grouzmann, I. Desbaillets, K. Frei, A. Fontana, and N. de Tribolet. 1992. Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. Cancer Res. 52: 4297–4305.

    PubMed  CAS  Google Scholar 

  92. van Ravenswaay Claasen, H. H., P. M. Kluin, and G. J. Fleuren. 1992. Tumor infiltrating cells in human cancer: on the possible role of CD16+ macrophages in antitumor cytotoxicity. Lab. Invest. 67: 166–174.

    PubMed  CAS  Google Scholar 

  93. Voest, E. E., B. M. Kenyon, M. S. O'Reilly, G. Truitt, R. J. D'Amato, and J. Folkman. 1995. Inhibition of angiogenesis in vivo by interleukin-12. J. Natl. Cancer Inst. 87: 581–586.

    Article  PubMed  CAS  Google Scholar 

  94. Walter, S., B. Bottazzi, D. Govoni, F. Colotta, and A. Mantovani. 1991. Macrophage infiltration and growth of sarcoma clones expressing different amounts of monocyte chemotactic protein/JE. Int. J. Cancer 49: 431–435.

    Article  PubMed  CAS  Google Scholar 

  95. Wang, J. M., O. Chertov, P. Proost, L. Jian-Jian, P. Menten, L. Xu, S. Sozzani, A. Mantovani, W. Gong, V. Schirrmacher, J. Van Damme, and J. J. Oppenheim. 1998. Purification and identification of chemokines potentially involved in kidney-specific metastasis by a murine lymphoma variant: induction of migration and NE-KB activation. Int. J. Cancer 75: 900–907.

    Article  PubMed  CAS  Google Scholar 

  96. Wang, J. M., G. Taraboletti, K. Matsushima, J. Van Damme, and A. Mantovani. 1990. Induction of haptotactic migration of melanoma cells by neutrophil activating protein/ interleukin-8. Biochem. Biophys. Res. Commun. 169: 165–170.

    Article  PubMed  CAS  Google Scholar 

  97. Yamashiro, S., M. Takeya, T. Nishi, J. Kuratsu, T. Yoshimura, Y. Ushio, and K. Takahashi. 1994. Tumor-derived monocyte chemoattractant protein-1 induces intratumoral infiltration of monocyte-derived macrophage subpopulation in transplanted rat tumors. Am. J. Pathol. 145: 856–867.

    PubMed  CAS  Google Scholar 

  98. Yoshimura, T., E. A. Robinson, S. Tanaka, E. Appella, J. Kuratsu, and E. J. Leonard. 1989. Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J. Exp. Med. 169: 1449–1459.

    Article  PubMed  CAS  Google Scholar 

  99. Zachariae, C. O., A. O. Anderson, H. L. Thompson, E. Appella, A. Mantovani, J. J. Oppenheim, and K. Matsushima. 1990. Properties of monocyte chemotactic and activating factor (MCAF) purified from a human fibrosarcoma cell line. J. Exp. Med. 171: 2177–2182.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Alberto Mantovani
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  2. Annunciata Vecchi
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  3. Silvano Sozzani
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  4. Antonio Sica
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  5. Paola Allavena
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Editors and Affiliations

  1. Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

    Barrett J. Rollins MD, PhD

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Mantovani, A., Vecchi, A., Sozzani, S., Sica, A., Allavena, P. (1999). Tumors as a Paradigm for the In Vivo Role of Chemokines in Leukocyte Recruitment. In: Rollins, B.J. (eds) Chemokines and Cancer. Contemporary Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-701-7_3

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  • DOI: https://doi.org/10.1007/978-1-59259-701-7_3

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4760-7

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