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An Algorithm for Diabetes Management During Glucocorticoid Therapy of Nonendocrine Disease

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Book cover Hormone Replacement Therapy

Part of the book series: Contemporary Endocrinology ((COE,volume 13))

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Abstract

For the patient who has pre-existing type 1 or type 2 diabetes mellitus or the patient with new-onset of diabetes during glucocorticoid therapy (“steroid diabetes”), glucocorticoid therapy of nonendocrine disease poses dilemmas. Glucocorticoid therapy exacerbates hyperglycemia, and tapering of a glucocorticoid dose without adjustment of diabetes therapy may result in severe hypoglycemia.

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References

  1. Ingle DJ, Sheppard R, Evans JS, Kuizenga MH. A comparison of adrenal steroid diabetes and pancreatic diabetes in the rat. Endocrinology 1945; 37: 341–356.

    Article  PubMed  CAS  Google Scholar 

  2. Bookman JJ, Drachman SR, Schaefer LE, Adlersberg D. Steroid diabetes in man. Diabetes 1953; 2: 100–111.

    PubMed  CAS  Google Scholar 

  3. Berg E-G. Nil nocere!: Über Schäden und Nebenwirkungen bei der therapeutischen Verwendung von Cortison and ähnlichen Steroidhormonen. Münchener Medizinische Wochenschrift 1956; 98: 1614–1622.

    PubMed  CAS  Google Scholar 

  4. Ranney HM, Gellhorn A. The effect of massive prednisone and prednisolone therapy on acute leukemia and malignant lymphomas. Am J Med 1957; 22: 405–413.

    Article  PubMed  CAS  Google Scholar 

  5. Simpson JR. Steroid diabetes: case report. Harper Hosp Bull 1957; 15: 43–51.

    PubMed  CAS  Google Scholar 

  6. Grilliat JP, Komig F, Vaillant G. Diabetes occurring during deltacortisone therapy of cirrhosis. Rev méd Nancy 1959; 84: 720–727.

    PubMed  CAS  Google Scholar 

  7. Baldwin HS, Dworotzky M, Isaacs NJ. Evaluation of the steroid treatment of asthma since 1950. J Allergy 1961; 32: 109–118.

    Article  PubMed  CAS  Google Scholar 

  8. Gregory RL, Sayle BA. Steroid diabetes. Texas State J Med 1962; 58: 788–793.

    CAS  Google Scholar 

  9. Mach RS, DeSousa RC. Coma avec hyperosmolalité et déshydratation chez des malades hyperglycémiques sans acidocétose. Schweizerische Medizinische Wochenschrift 1963; 93: 1256–1263.

    PubMed  CAS  Google Scholar 

  10. Blereau RP, Weingarten CM. Diabetic acidosis secondary to steroid therapy. N Engl J Med 1964; 271: 836

    Article  PubMed  CAS  Google Scholar 

  11. Keeney EL. The condition of asthmatic patients after daily long-term corticosteroid treatment. Arizona Med 1964; 21: 463–469.

    PubMed  CAS  Google Scholar 

  12. Miller SEP, Neilson JM. Clinical features of the diabetic syndrome appearing after steroid therapy. Postgrad Med J 1964; 40: 660–669.

    Article  PubMed  CAS  Google Scholar 

  13. Brocard H, Akoun G, Grand A. Diabéte stéroïde compliqué d’ un coma de type hyperosmolaire. Bulletins et Memoires de la Société Médicale des Hôpitaux de Paris 1965; 116: 353–363.

    PubMed  CAS  Google Scholar 

  14. Schwartz TB, Apfelbaum RI. Nonketotic diabetic coma. Yearbook Endocrinol 1965;1965–1966 series:165–181.

    Google Scholar 

  15. Walsh, Grant IWB. Corticosteroids in treatment of chronic asthma. Br Med J 1966; 2: 796–802.

    Article  PubMed  CAS  Google Scholar 

  16. Boyer MH. Hyperosmolar anacidotic coma in association with glucocorticoid therapy. JAMA 1.967; 202: 95–97.

    Google Scholar 

  17. Plauchu M, Paliard P, Malluret J, Noel P, De Montgolfier R. Un nouveau cas d’état d’hyperosmolarité plasmatique ou de coma hyperosmolaire déclenché par les corticoïdes chez un diabétique latent, porteur d’une lymphose. Lyons M 1967; 217: 1921–1932.

    CAS  Google Scholar 

  18. Zangel V, Masszi J. Ketozisba âtmenö steroid-diabetes hârom esete. Orvosi Hetilap 1967; 108: 395–396.

    PubMed  CAS  Google Scholar 

  19. Kumar RS. Hyperosmolar non-ketotic coma. Lancet 1968; 1: 48–49.

    Article  PubMed  CAS  Google Scholar 

  20. Pyörälä K, Suhonen O, Pentikäinan P. Steroid therapy and hyperosmolar non-ketotic coma. Lancet 1968; 1: 596–597.

    Article  PubMed  Google Scholar 

  21. Smyllie HC, Connolly CK. Incidence of serious complications of corticosteroid therapy in respiratory disease: a retrospective survey of patients in the Brompton Hospital. Thorax 1968; 23: 571–581.

    Article  PubMed  CAS  Google Scholar 

  22. Williams ER. Systemic lupus erythematosus and diabetes mellitus. Br J Clin Practice 1968; 22: 461–463.

    CAS  Google Scholar 

  23. Arai J, Miyakawa Y, Kataoka K, Matsuki S, Asano S. Case of fatal hypoglycemic coma during sulfonylurea administration for the therapy of steroid diabetes following adrenalectomy. Saishin Igaku Recent Med 1969; 24: 2524–2529.

    CAS  Google Scholar 

  24. Spenney JG, Eure CA, Kreisberg RA. Hyperglycemic, hyperosmolar, nonketoacidotic diabetes: a complication of steroid and immunosuppressive therapy. Diabetes 1969; 18: 107–110.

    PubMed  CAS  Google Scholar 

  25. Alavi IA, Sharma BK, Pillay VKG. Steroid-induced diabetic ketoacidosis. Am J Med Sci 1971; 262:(1)15–23.

    Google Scholar 

  26. Corcoran FH, Granatir RF, Schlang HA. Hyperglycemic hyperosmolar nonketotic coma associated with corticosteroid therapy. J Florida Med Assoc 1971; 58: 38–39.

    CAS  Google Scholar 

  27. Limas CJ, Samad A, Seff D. Hyperglycemic nonketotic coma as a complication of steroid therapy. NY State J Med 1971; 71: 1542–1543.

    CAS  Google Scholar 

  28. Szewczyk Z, Ratajczyk T, Rabczynski J. Hyperosmotic coma in steroid-induced diabetes complicating subacute glomerulonephritis in a 16-year-old boy. Polski Tygodnik Lekarski 1971; 26: 1988–1990.

    PubMed  CAS  Google Scholar 

  29. Daouk AA, Malek GH, Kauffman HM, Kisken WA. Hyperosmolar non-ketotic coma in a kidney transplant recipient. J Urol 1972; 108: 524–525.

    PubMed  CAS  Google Scholar 

  30. Lieberman P, Patterson R, Kunske R. Complications of long-term steroid therapy for asthma. J Allergy Clin Immunol 1972; 49: 329–336.

    Article  PubMed  CAS  Google Scholar 

  31. Owen OE, Cahill GF. Metabolic effects of exogenous glucocorticoids in fasted man. J Clin Invest 1973; 52: 2596–2605.

    Article  PubMed  CAS  Google Scholar 

  32. Ruiz JO, Simmons RL, Callender CO, Kjellstrand CM, Buselmeier TJ, Najarian JS. Steroid diabetes in renal transplant recipients: pathogenetic factors and prognosis. Surgery 1973; 73: 759–765.

    PubMed  CAS  Google Scholar 

  33. Hill CM, Douglas JF, Rajkumar KV, McEvoy J, McGeown MG. Glycosuria and hyperglycaemia after kidney transplantation. Lancet 1974; 2: 490–492.

    Article  PubMed  CAS  Google Scholar 

  34. Kendall-Taylor P. Hyperosmolar coma in Cushing’s disease. Lancet 1974; 1: 409.

    Article  Google Scholar 

  35. Klein W. Treatment with glucocorticoids in diabetic patients. Zeitschrift fur Allgemeinmedizin 1974; 50: 1101–1106.

    PubMed  CAS  Google Scholar 

  36. Simmons RL, Kjellstrand CM, Buselmeier TJ, Najarian JS. Glycosuria and hyperglycaemia after kidney transplantation. Lancet 1974; 2 (letter): 844.

    Google Scholar 

  37. Woods JE, Zincke H, Palumbo PJ, Johnson WJ, Anderson CF, Frohnert PP, et al. Hyperosmolar nonketotic syndrome and steroid diabetes: occurrence after renal transplantation. JAMA 1975; 231: 1261–1263.

    Article  PubMed  CAS  Google Scholar 

  38. Gunnarsson R, Amern P, Lundgren G, Magnusson G, Ostman J, Groth CG. Steroid diabetes after renal transplantation: a preliminary report. Scandinavian Journal of Urology and Nephrology 1977; 42: 191–194.

    PubMed  Google Scholar 

  39. David DS, Cheigh JS, Braun DW, Fotino M, Stenzel KH, Rubin AL. HLA-A28 and steroid-induced diabetes in renal transplant patients. JAMA 1980; 243: 532–533.

    Article  PubMed  CAS  Google Scholar 

  40. Pagano G, Lombardi A, Ferraris GM, Imbimbo B, Cavallo-Perin P. Acute effect of prednisone and deflazacort on glucose tolerance in prediabetic subjects. Eur J Clin Pharmacol 1982; 22: 469–471.

    Article  PubMed  CAS  Google Scholar 

  41. Perlman K, Ehrlich RM. Steroid diabetes in childhood. Am J Dis Childhood 1982; 136: 64–68.

    CAS  Google Scholar 

  42. Amer P, Gunnarsson R, Blomdahl S, Groth C-G. Some characteristics of steroid diabetes: a study in renal-transplant recipients receiving high-dose corticosteroid therapy. Diabetes Care 1983; 6: 23–25.

    Article  Google Scholar 

  43. Fujikawa LS, Meisler DM, Nozik RA. Hyperosmolar hyperglycemic nonketotic coma. A complication of short-term systemic corticosteroid use. Ophthalmology 1983; 90: 1239–1242.

    PubMed  CAS  Google Scholar 

  44. Pagano G, Cavallo-Perin P, Cassader M, Bruno A, Ozzello A, Masciola P. An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects. J Clin Invest 1983; 72: 1814–1820.

    Article  PubMed  CAS  Google Scholar 

  45. Ivanova II, Vasiutkova LA, Ivanov VA. Hyperglycemic coma after corticosteroid therapy. Sovetskaia Meditsina 1984; 10: 112–113.

    PubMed  Google Scholar 

  46. Lohr R. Precipitation of hyperosmolar nonketotic diabetes on alternate-day corticosteroid therapy (letter). JAMA 1984; 252: 628.

    Article  PubMed  CAS  Google Scholar 

  47. Ferguson RP. A comparison of steroid and thiazide diabetes. Connecticut Medicine 1986; 50: 506–509.

    PubMed  CAS  Google Scholar 

  48. Bruno A, Cavallo-Perin P, Cassader M, Pagano G. Deflazacort vs prednisone: effect on blood glucose control in insulin-treated diabetics. Arch Intern Med 1987; 147: 679–680.

    Article  PubMed  CAS  Google Scholar 

  49. Green stone MA, Shaw AB. Alternate day corticosteroid causes alternate day hyperglycaemia. Postgrad Med J 1987; 63: 761–764.

    Article  PubMed  CAS  Google Scholar 

  50. Thomas JW, Vertkin A, Nell LJ. Antiinsulin antibodies and clinical characteristics of patients with systemic lupus erythematosus and other connective tissue diseases with steroid induced diabetes. J Rheumatol 1987; 14: 732–735.

    PubMed  CAS  Google Scholar 

  51. Wachtel TJ SR, Lamberton P. Predisposing factors for the diabetic hyperosmolar state. Arch Intern Med 1987; 147: 499–501.

    Article  PubMed  CAS  Google Scholar 

  52. Black DM, Filak AT. Hyperglycemia with non-insulin-dependent diabetes following intraarticular steroid injection. J Family Practice 1989;28:(4)462–463.

    Google Scholar 

  53. Shi MZ, Zhang SF. Steroid diabetes: an analysis of 28 cases. Chinese J Intern Med 1989; 28: 139–141.

    CAS  Google Scholar 

  54. Ekstrand AV. Effect of steroid-therapy on insulin sensitivity in insulin-dependent diabetic patients after kidney transplantation. J Diabetic Complic 1991;5:(4)244–248.

    Google Scholar 

  55. Hricik DE, Bartucci MR, Moir EJ, Mayes JT, Shulak JA. Effects of steroid withdrawal on posttransplant diabetes mellitus in cyclosporine-treated renal transplant recipients. Transplantation 1991; 51: 374–377.

    Article  PubMed  CAS  Google Scholar 

  56. Ogawa A, Johnson JH, Ohneda M, McAllister CT, Inman L, Alam T, et al. Roles of insulin resistance and ß-cell dysfunction in dexamethasone-induced diabetes. J Clin Investig 1992; 90: 497–504.

    Article  PubMed  CAS  Google Scholar 

  57. Gurwitz JH, Bohn RL, Glynn RJ, Monane M, Mogun H, Avorn J. Glucocorticoids and the risk for initiation of hypoglycemic therapy. Arch Int Med 1994; 154: 97–101.

    Article  CAS  Google Scholar 

  58. Haggerty RD, Bergsman K, Edelson GW. Steroid-induced diabetic ketoacidosis. Practical Diabetology 1995; 14: 24–25.

    Google Scholar 

  59. McMahon M, Gerich J, Rizza R. Effects of glucocorticoids on carbohydrate metabolism. Diabetes Metab Rev 1988; 4: 17–30.

    Article  PubMed  CAS  Google Scholar 

  60. Genuth SM. Diabetes secondary to other endocrine dysfunctions. Clinical Diabetes 1990; 8: 74–79.

    Google Scholar 

  61. O’Byrne S F.J. Effects of drugs on glucose tolerance in non-insulin dependent diabetes (part I and II). Drugs 1990; 40: 203–219.

    Article  PubMed  Google Scholar 

  62. Caldwell JR, Furst DE. The efficacy and safety of low-dose corticosteroids for rheumatoid arthritis. Seminars in Arthritis and Rheumatism 1991;21:(1)1–11.

    Google Scholar 

  63. Pandit MK BJ, Gustafson AB. Drug-induced disorders of glucose tolerance. Ann Intern Med 1993; 118: 529–540.

    PubMed  CAS  Google Scholar 

  64. Kirwan JR. Systemic corticosteroids in rheumatology. In: Klippel JH, Dieppe PA, eds. Rheumatology. Mosby, London, 1994: 1–6.

    Google Scholar 

  65. Hetenyi G, Jr., Karsh J. Cortisone therapy: a challenge to academic medicine in 1959–1952. Perspect Biol Med 1997; 40: 426–439.

    PubMed  Google Scholar 

  66. Kayne DM, Holvey SM. Drugs and hormones that increase blood glucose levels. In: Lebovitz HE, DeFronzo RA, Genuth S, Kreisberg RA, Pfeifer MA, Tamborlane WV, eds. Therapy for diabetes mellitus and related disorders, 2nd ed. American Diabetes Association, Alexandria, 1994, pp. 185–190.

    Google Scholar 

  67. Raskin P, Beebe CA, Davidson MB, Nathan D, Rizza RA, Sherwin R, eds. Pharmacologic intervention. In: Medical management of non-insulin-dependent (Type II) diabetes, 3rd ed. American Diabetes Association, Alexandria, 1994, pp. 40–49.

    Google Scholar 

  68. Santiago JV, Goldstein DE, Haymond M, Heins J, Schiffrin A, Simonson DC, et al., eds. Insulin treatment. In: Medical Management of Insulin-Dependent (Type I) Diabetes, 2nd ed. American Diabetes Association, Alexandria, 1994, pp. 35–51.

    Google Scholar 

  69. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus AD. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20: 1183–1197.

    Google Scholar 

  70. American Diabetes Association. Standards of medical care for patients with diabetes mellitus (position statement). Diabetes Care 1997;20:(Suppl 1)S5–S13.

    Google Scholar 

  71. American Diabetes Association. Urine glucose and ketone determinations (position statement). Diabetes Care 1996;19:(Suppl 1)S35.

    Google Scholar 

  72. American Diabetes Association. Self-monitoring of blood glucose (consensus statement). Diabetes Care 1996; 19: S62 - S66.

    Google Scholar 

  73. Metz R, Nice M, LaPlaca G. Evaluation of an eight-hour therapeutic regimen in uncontrolled diabetes. Diabetes 1967; 16: 341–345.

    PubMed  CAS  Google Scholar 

  74. Skyler JS, Seigler DE, Reeves ML. A comparison of insulin regimens in insulin-dependent diabetes mellitus. Diabetes Care 1983; 5: 11–18.

    Google Scholar 

  75. Zinman B. The physiologic replacement of insulin: an elusive goal. N Engl J Med 1989; 321: 363–370.

    Article  PubMed  CAS  Google Scholar 

  76. Genuth S. Insulin use in NIDDM. Diabetes Care 1990; 13: 1240–1264.

    Article  PubMed  CAS  Google Scholar 

  77. Gavin LA. Perioperative management of the diabetic patient. Endocrinol Metab Clinics North Amer 1992; 21: 457–473.

    CAS  Google Scholar 

  78. Home PD, Alberti KGMM. Insulin therapy. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, eds. International Textbook of Diabetes Mellitus. John Wiley and Sons Ltd., Chichester, 1992: 831–864.

    Google Scholar 

  79. Koivisto VA. Insulin therapy in type II diabetes. Diabetes Care 1993; 16: 29–39.

    PubMed  Google Scholar 

  80. Lasker RD. The diabetes control and complication trial: implications for policy and practice. N Engl J Med 1993; 329: 1035–1036.

    Article  PubMed  CAS  Google Scholar 

  81. Zinman B. Insulin regimens and strategies for IDDM. Diabetes Care 1993; 16: 24–28.

    PubMed  Google Scholar 

  82. Rosenzweig JL. Principles of insulin therapy. In: Kahn CR,Weir GC, eds. Joslin’ s Diabetes Mellitus, 13th ed. Lea and Febiger, Philadelphia, 1994, pp. 460–488.

    Google Scholar 

  83. Wolfsdorf JI, Anderson BJ, Pasquarello C. Treatment of the child with diabetes. In: Kahn CR, Weir GC, ed. Joslin’s Diabetes Mellitus, 13th ed. Lea and Febiger, Philadelphia, 1994, pp. 530–551.

    Google Scholar 

  84. Goldstein DE, Little RR, Lorenz RA, Malone JI, Nathan D, Peterson CM. Tests of glycemia in diabetes. Diabetes Care 1995; 18: 896–909.

    PubMed  CAS  Google Scholar 

  85. Hirsch IB, Paauw DS, Brunzell J. Inpatient management of adults with diabetes. Diabetes Care 1995; 18: 870–878.

    PubMed  CAS  Google Scholar 

  86. Hawkins JB, Morales CM, Shipp JC. Insulin requirement in 242 patients with type II diabetes mellitus. Endocrine Practice 1996; 1: 385–389.

    Google Scholar 

  87. Siminerio LM, Carroll PB. Educating secondary diabetes patients. Diabetes Spectrum 1994; 7: 8–14.

    Google Scholar 

  88. Coles RS. Steroid therapy in uveitis. Int Ophthalmol Clin 1966; 6: 869–901.

    Article  PubMed  CAS  Google Scholar 

  89. Koehler BE, Urowitz MB, Killinger DW. The systemic effects of intra-articular corticosteroid. J Rheumatol 1974;1:(l)117–125.

    Google Scholar 

  90. Gottlieb NL, Riskin WG. Complications of local corticosteroid injections. JAMA 1980;243:(15)1547–1548.

    Google Scholar 

  91. Armstrong RD, English J, Gibson T, Chakroborty J, Marks V. Serum methylprednisolone levels following intra-articular injection of methylprednisolone acetate. Ann Rheum Diseases I981; 40: 571–574.

    Google Scholar 

  92. Bertouch JV, Meffin PJ, Sallustio BC, Brooks PM. A comparison of plasma methylprednisolone concentrations following intra-articular injection in patients with rheumatoid arthritis and osteoarthritis. Aust NZ J Med 1983; 13: 583–586.

    Article  CAS  Google Scholar 

  93. Weiss S, Kisch ES, Fischel B. Systemic effects of intraarticular administration of triamcinolone hexacetonide. Isr J Med Sci 1983; 19: 83–84.

    PubMed  CAS  Google Scholar 

  94. Lim KC, Walsh CH. Diabetic ketoalkalosis: a readily misdiagnosed entity. Br Med J 1976; 2: 19.

    Article  PubMed  CAS  Google Scholar 

  95. Sanders G, Boyle G, Hunter S, Poffenbarger PL. Mixed acid-base abnormalities in diabetes. Diabetes Care 1978; 1: 362–364.

    Article  PubMed  CAS  Google Scholar 

  96. Pearson DW, Thomson JA, Kennedy AC, Toner PG, Ratcliffe JG. Diabetic ketoalkalosis due to ectopic ACTH production from an oat cell carcinoma. Postgrad Med J 1981; 57: 455–456.

    Article  PubMed  CAS  Google Scholar 

  97. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–986.

    Article  Google Scholar 

  98. Braithwaite SS, Barr WG, Thomas JD. Diabetes management during glucocorticoid therapy of nonendocrine disease. Endocr Prac 1996; 2: 320–325.

    CAS  Google Scholar 

  99. Weinstein SP, Holand A, O’Boyle F, Haber RS. Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle. Metab Clin Exp 1993; 42: 1365–1369.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Susan S. Braithwaite MD
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  2. Walter G. Barr MD
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  3. Amer Rahman MD
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  4. Shaista Quddusi MD
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Editors and Affiliations

  1. Division of Endocrinology and Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA

    A. Wayne Meikle MD

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Braithwaite, S.S., Barr, W.G., Rahman, A., Quddusi, S. (1999). An Algorithm for Diabetes Management During Glucocorticoid Therapy of Nonendocrine Disease. In: Meikle, A.W. (eds) Hormone Replacement Therapy. Contemporary Endocrinology, vol 13. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-700-0_11

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  • DOI: https://doi.org/10.1007/978-1-59259-700-0_11

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