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Physiology and Molecular Biology of Placental Lactogen in Human Pregnancy

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Molecular and Cellular Pediatric Endocrinology

Part of the book series: Contemporary Endocrinology ((COE,volume 10))

Abstract

Human placental lactogen (hPL) is a protein hormone that has striking homologies in its chemical and biological properties to human growth hormone (hGH) and human prolactin (hPRL) (1,2). In this chapter, we will briefly discuss the role of hPL in the regulation of fetal growth and the regulation of hPL secretion in normal and pathologic pregnancies. We will then focus on recent advances in the regulation of hPL gene expression, giving particular attention to roles of nuclear hormone receptors and cytokines in transactivation of the hPL promoter.

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Authors
  1. Randall G. Richards PhD
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  2. Stuart Handwerger MD
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Editors and Affiliations

  1. Division of Endocrinology, Children’s Hospital Medical Center, Cincinnati, OH, USA

    Stuart Handwerger MD

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Richards, R.G., Handwerger, S. (1999). Physiology and Molecular Biology of Placental Lactogen in Human Pregnancy. In: Handwerger, S. (eds) Molecular and Cellular Pediatric Endocrinology. Contemporary Endocrinology, vol 10. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-697-3_15

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  • DOI: https://doi.org/10.1007/978-1-59259-697-3_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5875-7

  • Online ISBN: 978-1-59259-697-3

  • eBook Packages: Springer Book Archive

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