Skip to main content
SpringerLink
Log in
Book cover

Intraoperative Irradiation pp 379–395Cite as

IORT for Bone Sarcomas

  • Chapter

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Bone sarcomas are rare entities in clinical oncology, in which the histological subtype and site of involvement define the natural history of the disease and in particular the appropriate treatment strategy (1). Ewing sarcoma is a chemo- and radiation-sensitive disease in which combined-modality therapy (more recently including a surgical component) is mandatory for radical management (2). Osteosarcoma survival rates have been significantly improved by adjuvant chemotherapy and extremity preservation rates by neoadjuvant chemotherapy (3). Other uncommon bone sarcomas such as malignant fibrous histiocytoma (MFH) or chondrosarcoma are considered marginally sensitive to chemotherapy or radiotherapy and the primary radical treatment modality is surgery (4,5).A universal feature in the natural history of bone sarcomas is the tendency to involve the extraosseous soft tissue and neurovascular structures once the tumor growth and infiltration acquires a certain size.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Malawer MM, Link MP, and Donaldson SS. Sarcomas of the bone. In VT De Vita, S Hellman, and SA Rosenberg (eds.) Principles and Practice of Oncology, 5th ed. Lippincott-Raven, Philadelphia, 1997, pp. 1789–1816.

    Google Scholar 

  2. Rosen G. Primary Ewing’s sarcoma: the multidisciplinary lesion, Int. J. Radiat. Oncol. Biol. Phys., 4 (1978) 527–532.

    Article  PubMed  CAS  Google Scholar 

  3. Glasser DB, Lane JM, Huvos AG, Marcove RC, and Rosen G. Survival prognosis, and therapeutic response in osteogenic sarcoma. The Memorial Hospital experience, Cancer, 69 (1992) 698–708.

    Article  PubMed  CAS  Google Scholar 

  4. McCarthy SF, Matsuao F, and Dorfman HD. Malignant fibrous histiocytoma of bone: a study of 35 cases, Hum. Path., 10 (1979) 57–70.

    Article  PubMed  CAS  Google Scholar 

  5. Marcove RC. Chondrosarcoma: diagnosis and treatment, Orthop. Clin. Nort. Am, 8 (1977) 811–819.

    CAS  Google Scholar 

  6. Cortes EP, Holland JF, Wang, JJ, et al. Amputation and Adriamicyn in primary osteosarcoma, N. Engl. J. Med., 291 (1974) 998–1000.

    Article  PubMed  CAS  Google Scholar 

  7. Eilber FR, Eckhardt J, and Morton DL. Advances in the treatment of sarcomas of the extremity. Current status of limb salvage, Cancer, 54 (1984) 2695–2701.

    Google Scholar 

  8. Calvo FA, Antos M, and Brady LW. Intraoperative Radiotherapy. Clinical experiences and results, Springer Verlag, Heidelberg, 1992.

    Book  Google Scholar 

  9. Martinez A, Goffinet DR, Donaldson SS, et al. Intra-arterial infusion of radiosesnitizer (BUdR) combined with hypofractionated irradiation and chemotherapy for primary treatment of osteogenic sarcoma, Int. J. Radiat. Oncol. Biol. Phys., 2 (1980) 123–128.

    Google Scholar 

  10. Tefft M, Razek A, Perez C, et al. Local control and survival related to radiation dose and colume and to chemotherapy in non metastatic Ewing’ s sarcoma of the pelvic bones, Int. J. Radiat. Oncol. Biol. Phys., 4 (1978) 367–372.

    Article  PubMed  CAS  Google Scholar 

  11. Krochak R, Harwood AR, Cummings BJ, et al. Results of radical radiation for chondrosarcoma of bone, Radiother. Oncol., 1 (1983) 109–115.

    Article  PubMed  CAS  Google Scholar 

  12. Calvo FA, Ortíz De Urbina D, Sierrasesumaga L, Abuchaibe O, Azinovic I, Antillon F, Santos M, and Caiïadell J. Intraoperative radiotherapy in the multidisciplinary treatment of bone sarcomas in children and adolescents, Med. Pediatr. Oncol., 19 (1991) 478–485.

    Article  PubMed  CAS  Google Scholar 

  13. Barbieri E, Emiliani E, Zini G, Mancini A, Toni A, et al. Combined therapy of localised Ewing’s sarcoma of bone: analysis of results in 100 patients, Int. J. Radiat. Oncol. Biol. Phys., 19 (1990) 1165–1170.

    Article  PubMed  CAS  Google Scholar 

  14. Dunst J, Jürgens H, Sauer R, Pape H, Paulussen M, Winkelmann W, and Riibe CH. Radiation therapy in Ewing’s sarcoma: an update of the CESS 86 trial, Int. J. Radiat. Oncol. Biol. Phys., 32 (1995) 919–930.

    Article  PubMed  CAS  Google Scholar 

  15. Halperin EC, Kun LX, Constantine LS, and Tarbell NJ. Pediatric Radiation Oncology, Raven Press, New York, 1989.

    Google Scholar 

  16. Brown AP, Fixen JA, and Plowman PN. Local control of Ewing’ s sarcoma: an analysis of 67 patients, Br. J. Radiol., 60 (1987) 261–268.

    Article  PubMed  CAS  Google Scholar 

  17. Tepper J, Glaubiguer D, Lichter A, Wackenbut J, and Glatstein E. Local control of Ewing’ s sarcoma of bone with radiotherapy and combination chemotherapy, Cancer, 46 (1980) 1965–1973.

    Article  Google Scholar 

  18. Marcus RB, and Million RR. The effect of primary tumor size on the prognosis of Ewing’s sarcoma, Int. J. Radiat. Oncol. Biol. Phys., 10 (Suppl 1) (1994) 88.

    Google Scholar 

  19. Bacci G, Picci P, Gitelis S, Borghi A, and Campanacci M. The treatment of localized Ewing’s sarcoma. The experience at the Instituo Ortopedico Rizzoli in 163 cases treated with and without adjuvant chemotherapy, Cancer, 49 (1982) 1561–1570.

    Article  PubMed  CAS  Google Scholar 

  20. Jurgens H, Exner U, Gadner H, et al. Multidisciplinary treatment of primary Ewing’s sarcoma of bone. A 6-year experience of a European Cooperative Trial, Cancer, 61 (1988) 23–32.

    Article  PubMed  CAS  Google Scholar 

  21. Sailder SL, Harmon DC, Mankin HJ, Truman JT, and Suit HD. Ewing’ s sarcoma: surgical resection as a prognostic factor, Int. J. Radiat. Oncol. Biol. Phys., 15 (1988) 43–52.

    Article  Google Scholar 

  22. Evans R, Nesbit M, Gehan E, Garnsey L, et al. Multimodal therapy for the management of localized Ewing’s sarcoma of pelvic and sacral bones: a report from the second intergroup study, J. Clin. Oncol., 9 (1991) 1173–1180.

    PubMed  CAS  Google Scholar 

  23. Kronholz K, Prott FJ, Anders C, and Willich N. Flabs zur intraoperativen Bestrahlung. Medizinische Physik. Hrsg: H. Leitner, G. Stücklshweiger, S. 1996, pp. 39–40.

    Google Scholar 

  24. Enneking WF. A system of staging musculoskeletal neoplasms, Ballieere ‘s Clinical Oncology, 1 (1987) 97–110.

    Google Scholar 

  25. Brant T, Parsons J, Marcus R, Spanier S, Heare T, et al. Preoperative irradiation for soft tissue sarcomas of the trunk and extremities in adults, Int. J. Radiat. Oncol. Biol. Phys., 19 (1990) 899–906.

    Article  PubMed  CAS  Google Scholar 

  26. Kinsella TJ, Sindelar WF, and De Luca AM. Threshold dose for peripheral nerve injury following intraoperative radiotherapy (IORT) in a large animal model, Int. J. Radiat. Oncol. Biol. Phys.,15 (Suppl 1) 205.

    Google Scholar 

  27. Powers BE, Gillette EL, Mcchesney SL, et al. Muscle injury following experimental intraoperative irradiation, Int. J. Radiat. Oncol. Biol. Phys., 17 (Suppl 1) (1989) 246.

    Article  Google Scholar 

  28. Gillete EL, Powers BE, Mcchesney SL, et al. Response of aorta and branch arteries to experimental intraoperative irradiation, Int. J. Radiat. Oncol. Biol. Phys., 15 (suppl 1) (1988) 202.

    Google Scholar 

  29. Powers BE, Gillette EL, Mcchesney SL, et al. Bone necrosis and tumor induction following experimen- tal intraoperative irradiation, Int. J. Radiat. Oncol. Biol. Phys., 17 (1989) 559–567.

    Article  PubMed  CAS  Google Scholar 

  30. Le Coteur RA, Gillette EL, Powers BE, et al. Peripheral neuropathies following experimental intraoperative radiation therapy (IORT), Int. J. Radiat. Oncol. Biol. Phys., 11 (1989) 1579–1585.

    Google Scholar 

  31. Kinsella TJ, Sindelar WF, De Luca AM, Tolerance of peripheral nerve to intraoperative radiotherapy (IORT): clinical and experimental studies, Int. J. Radiat. Oncol. Biol. Phys.,11 (1985) 15791585.

    Google Scholar 

  32. Powers BE, Gillette EL, Mcchesney SL, et al. Bone necrosis and tumor induction following experimental intraoperative irradiation, Int. J. Radiat. Oncol. Biol. Phys., 17 (1989) 559–567.

    Article  PubMed  CAS  Google Scholar 

  33. Rosen G, Caparros B, Nirenberg A, Marcove RC, Huvos AG, Kosloff C, Lane J, and Murphy ML. Ewing’s sarcoma. Ten-years experience with adjuvant chemotherapy, Cancer, 47 (1981) 2204–2213.

    Article  PubMed  CAS  Google Scholar 

  34. Eilber F, Giuliano A, Edkardt J, Patterson K, Moseley S, and Goonight J. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial, J. Clin. Oncol., 5 (1987) 21–26.

    PubMed  CAS  Google Scholar 

  35. Bacci G, Springfield D, Capnna R, et al. Neoadjuvant chemotherapy for osteosarcoma of the extremity, Clin. Orthop., 224 (1987) 268–276.

    PubMed  Google Scholar 

  36. Wong ACW, Akahoshi Y, Takeuchi S. Limb-salvage procedures of osteosarcoma: an alternative to amputation, Int. Orthop., 10 (1986) 245–251.

    Article  PubMed  CAS  Google Scholar 

  37. Sugimoto M, Togochida J, Kotoura Y, Yamamuro T, and Utsumi H. In vitro radiosensitivity of osteosarcoma lines, Strahlenther. Onkol., 165 (1989) 782.

    Google Scholar 

  38. Poppe E, Liverud K, and Efskind. Osteosarcoma, Acta Chir. Scand., 134 (1968) 549–556.

    PubMed  CAS  Google Scholar 

  39. Allen CF and Stevens KR. Preoperative irradiation for osteogenic sarcoma, Cancer,31 (1973) 13641366.

    Google Scholar 

  40. Jenkin RDT, Allt WEC, and Fitzpatrik PJ. Osteosarcoma: an assessment of management with particular reference to primary irradiation and selective delayed amputation, Cancer, 30 (1972) 393–400.

    Article  PubMed  CAS  Google Scholar 

  41. Philips TL and Sheline GE. Radiation therapy of malignant bone tumors, Radiology,92 (1969) 15371545.

    Google Scholar 

  42. Chambers RG and Mahoney WD. Osteogenic sarcoma of the mandible: current management, Am. Surg. 36 (1970) 463–471.

    PubMed  CAS  Google Scholar 

  43. Suit HD. Radiotherapy in osteosarcoma, Clin. Orthop., 111 (1975) 71–75.

    Article  PubMed  Google Scholar 

  44. Breur K, Cohen P, Schweisguth O, and Amm H. Irradiation of the lungs or an adjuvant therapy in the treatment of osteosarcoma of the limbs. An EORTC randomized study, Eur. J. Cancer, 14 (1978) 461–471.

    PubMed  CAS  Google Scholar 

  45. Burgers JM, van Glabbeke M, Bussan A, et al. Osteosarcoma of the limbs. Report of the EORTC-SIOP 03 trial 20781 investigating the value of adjuvant treatment with chemotherapy and/or prophylactic lung irradiation, Cancer, 61 (1988) 1024–1031.

    Article  PubMed  CAS  Google Scholar 

  46. Farrell C and Raventos A. Experiences in treating osteosarcoma at the hospital of the University of Pennsylvania, Radiology, 83 (1964) 1080–1083.

    PubMed  CAS  Google Scholar 

  47. Cavaliere R. Hyperthermic treatment of osteogenic sarcoma, Chemoter. Oncol., 2 (1978) 190–196.

    Google Scholar 

  48. Abe M, Takahashi M, Shibamoto Y, and Ono K. Application of intraoperative radiation therapy to refractory cancers, Ann. Radiol., 32 (1989) 493–194.

    PubMed  CAS  Google Scholar 

  49. Nagashima T, Yamamuro T, Kotoura Y, Takahashi M, and Abe M. Histological studies of the effect of intraoperative irradiation on osteosarcoma, Nippon Seikeigeka Gakkai Zasshi, 57 (1983) 1681–1697.

    PubMed  CAS  Google Scholar 

  50. Yamamuro T, Kotoura Y, Kasahara K, Tadahashi M, and Abe M. Intraoperative radiotherapy for osteosarcoma, Strahlecther. Onkol., 165 (1989) 783.

    Google Scholar 

  51. Abe M, Takahashi M, Shibamoto Y, Ono K, Yabumoto E, and Mori K. Derzeitige Stellung der intraoperativen Strahlentherapie, Chirurg., 59 (1988) 211–217.

    PubMed  CAS  Google Scholar 

  52. Kotoura Y, Yamamuro T, Kasahara K, Shibamoto Y, Takahashi M, and Abe M. Intraoperative radiation therapy for malignant bone tumors. In FW Schildberg, N Willich, and HJ Krämling (eds.) Intraoperative Radiation Therapy, Die Blane Eule, Essen, 1993, pp. 456–458.

    Google Scholar 

  53. Rosenberg SA, Tepper JE, Glastein EJ, et al. The treatment of soft tissue sarcomas of the extremities. Prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy, Ann. Surg. 196 (1982) 305–314.

    Article  PubMed  CAS  Google Scholar 

  54. Feldman F and Norman D. Intra and extraosseus malignant hi stiocytomas (malignant fibrous xanthoma) of bone, Radiology, 104 (1972) 97–108.

    Google Scholar 

  55. Campana R, Bertoni F, Baccini P, Bacci G, Gerra A, and Camapanacci M. Malignant fibrous histicytoma of bone. The experience at the Rizzoli Institute: report of 90 cases, Cancer, 54 (1984) 177–187.

    Google Scholar 

  56. Spanier SS, Enneking WF, and Enriquez P. Primary malignant fibrous histiocytoma of bone, Cancer, 36 (1975) 2084–2098.

    Article  PubMed  CAS  Google Scholar 

  57. Bacci G, Avella M, Picc I et al. The effectiveness of chemotherapy in localized malignant fibrous histiocytoma of bone: the Rizzoli Institute Experience with 66 patients treated with surgery alone or surgery + adjuvant or neoadjuvant chemotherapy, Chemioterapie, 7 (1989) 481–494.

    Google Scholar 

  58. Castillo I, Calvo FA, Aristu J, et al. Tratamiento intensive de sarcomas óseos de histología miscelânea: histiocitoma fibroso maligno y condrosarcoma, Oncología, 15 (1992) 351–358.

    Google Scholar 

  59. Stea et al. 1987.

    Google Scholar 

Download references

Authors
  1. Felipe A. Calvo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Luis Sierrasesumaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Norman Willich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Santiago Amillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. José Cañadell
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Mayo Clinic and Mayo Medical School, Rochester, MN, USA

    Leonard L. Gunderson MD, MS (Professor and Chair of Oncology) (Professor and Chair of Oncology)

  2. Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Christopher G. Willet MD

  3. Albert Einstein College of Medicine and Beth Israel Cancer Center, New York, NY, USA

    Louis B. Harrison MD

  4. University Hospital Gregorio Marañón, Madrid, Spain

    Felipe A. Calvo MD (Chair of Oncology) (Chair of Oncology)

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Calvo, F.A., Sierrasesumaga, L., Willich, N., Amillo, S., Cañadell, J. (1999). IORT for Bone Sarcomas. In: Gunderson, L.L., Willet, C.G., Harrison, L.B., Calvo, F.A. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-696-6_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-696-6_21

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5576-3

  • Online ISBN: 978-1-59259-696-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation