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Intraoperative Irradiation pp 201–222Cite as

IORT in Pancreatic Carcinoma

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Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Current surgical treatment for adenocarcinoma of the pancreas is based on the surgical procedure of pancreaticoduodenectomy as first described by Whipple et al. (1). However, because of tumor relapse in the liver, peritoneum, and the bed of the resected pancreas, surgery alone cures no more than 25% of patients who undergo resection (2–5). In fact, local recurrence has been documented in 50 to 90% of patients after pancreaticoduodenectomy (6–10). Attempts to improve local control and survival by performing extended lymphatic resection have met with conflicting results (8, 11–14) and in some centers have been associated with unacceptable morbidity and mortality (15–17). In a series from Japan, extended resection did not prevent local recurrence unless combined with intra-operative irradiation (IORT) (13,14).

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Authors
  1. Paula M. Termuhlen
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  2. Douglas B. Evans
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  3. Christopher G. Willett
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Editor information

Editors and Affiliations

  1. Mayo Clinic and Mayo Medical School, Rochester, MN, USA

    Leonard L. Gunderson MD, MS (Professor and Chair of Oncology) (Professor and Chair of Oncology)

  2. Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Christopher G. Willet MD

  3. Albert Einstein College of Medicine and Beth Israel Cancer Center, New York, NY, USA

    Louis B. Harrison MD

  4. University Hospital Gregorio Marañón, Madrid, Spain

    Felipe A. Calvo MD (Chair of Oncology) (Chair of Oncology)

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Termuhlen, P.M., Evans, D.B., Willett, C.G. (1999). IORT in Pancreatic Carcinoma. In: Gunderson, L.L., Willet, C.G., Harrison, L.B., Calvo, F.A. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-696-6_12

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  • DOI: https://doi.org/10.1007/978-1-59259-696-6_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5576-3

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