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Peripheral Nerve Tolerance

Experimental and Clinical

  • Chapter
Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Neuropathies are uncommon, but serious, complications following radiation therapy. Radiation therapy of gynecologic tumors in 2410 patients resulted in lumbosacral plexopathies in only four patients (1). It was estimated that the lumbosacral plexus of those patients had received over 70 Gy given by a combination of implants and fractionated external-beam irradiation (EBRT).

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References

  1. Georgiou A, Grigsby PW, and Perez CA. Radiation-induced lumbosacral plexopathy in gynecologic tumors: clinical findings and dosimetric analysis, Int. J. Radiat. Oncol. Biol. Phys., 26 (1993) 479–482.

    Article  PubMed  CAS  Google Scholar 

  2. Kinsella Ti, Sindelar WF, Deluca AM, et al. Tolerance of peripheral nerve to intraoperative radiotherapy (IORT): clinical and experimental studies, Int. J. Radiat. Oncol. Biol. Phys., 11 (1985) 1579–1585.

    Article  PubMed  CAS  Google Scholar 

  3. Kinsella TJ, Deluca AM, Barnes M, Anderson W, Terrill R, and Sindelar WF. Threshold dose for peripheral neuropathy following intraoperative radiotherapy (IORT) in a large animal model, Int. J. Radiat. Oncol. Biol. Phys., 20 (1991) 697–701.

    Article  PubMed  CAS  Google Scholar 

  4. LeCouteur RA, Gillette EL, Powers EL, Child G, McChesney SL, and Ingram TU. Peripheral neuropathies following experimental intraoperative radiation therapy (IORT), Int. J. Radiat. Oncol. Biol. Phys., 17 (1989) 583–590.

    Article  PubMed  CAS  Google Scholar 

  5. Vujaskovic Z, Gillette SM, Powers BE, et al. Intraoperative radiation (IORT) injury to sciatic nerve in a large animal model, Radiother. Oncol., 30 (1994) 133–139.

    Article  PubMed  CAS  Google Scholar 

  6. Bentzen SM, Turesson I, and Thames HD. Fractionation sensitivity and latency of telangiectasia after post-mastectomy radiotherapy: a graded-response analysis, Radiother. Oncol., 18 (1990) 95–106.

    Article  PubMed  CAS  Google Scholar 

  7. Shaw EG, Gunderson LL, Martin JK, Beart RW, Nagorney DM, and Podratz KC. Peripheral nerve and ureteral tolerance to intraoperative radiation therapy: clinical and dose-response analysis, Radiother. Oncol., 18 (1990) 247–255.

    Article  PubMed  CAS  Google Scholar 

  8. Vujaskovic Z, Gillette SM, Powers BE, et al. Effects of intraoperative irradiation and intraoperative hyperthermia on canine sciatic nerve: neurologic and electrophysiologic study, Int. J. Radiat. Oncol. Biol. Phys., 34 (1996) 125–131.

    Article  PubMed  CAS  Google Scholar 

  9. Gillete EL, Gillette SM, Vujaskovic Z, et al. Influence of volume on canine ureters and peripheral nerves irradiated intraoperatively. In Schildberg FW, Willich N, and Krämling H (eds.). Intraoperative Radiation Therapy—Proceedings 4th International IORT Symposium, Munich, 1992, Essen. Verlag Die Blaue Eule, 1993, pp. 61–63.

    Google Scholar 

  10. Sindelar WF, Hoekstra H, Restrepo C, and Kinsella Ti. Pathological tissue changes following intraoperative radiotherapy, Am. J. Clin. Oncol., 9 (1986) 504–509.

    Article  PubMed  CAS  Google Scholar 

  11. Johnstone PA, Sindelar WF, and Kinsella TJ. Experimental and clinical studies of intraoperative radiation therapy, Curr. Probi. Cancer, 18 (1994) 249–292.

    CAS  Google Scholar 

  12. Sindelar WF, Kinsella TJ, Chen PW, et al. Intraoperative radiotherapy in retroperitoneal sarcomas: final results of a prospective, randomized trial, Arch. Surg., 128 (1993) 402–410.

    Article  PubMed  CAS  Google Scholar 

  13. Gunderson LL, Nelson H, Martenson J, et al. Locally advanced primary colorectal cancer—intraoperative electron and external beam irradiation ± 5-FU, Int. J. Radiat. Oncol. Biol. Phys., 37 (1997) 601–614.

    Article  PubMed  CAS  Google Scholar 

  14. Gunderson LL, Nelson H, Martenson J, et al. Intraoperative electron and external beam irradiation ± 5-FU and maximal surgical resection for previously unirradiated locally recurrent colorectal cancer, Dis. Colon Rectum, 39 (1996) 1379–1395.

    Article  PubMed  CAS  Google Scholar 

  15. Tepper JE, Gunderson LL, Goldson AL, et al. Quality control parameters of intraoperative irradiation, Int. J. Radiation Oncol. Biol. Phys., 12 (1986) 1687–1695.

    Article  CAS  Google Scholar 

  16. Tepper JE, Gunderson LL, Orlow E, et al. Complications of intraoperative radiation therapy, Int. J. Radiat. Oncol. Biol. Phys., 10 (1984) 1831–1839.

    Article  PubMed  CAS  Google Scholar 

  17. Schild SE, Martenson JA, Gunderson LL, and Dozois RR. Long-term survival and patterns of failure after postoperative radiation therapy for subtotally resected rectal adenocarcinoma, Int. J. Radiat. Oncol. Biol. Phys., 16 (1989) 459–463.

    Article  PubMed  CAS  Google Scholar 

  18. Peters GJ and VanderVijgh WJF. Protection of normal tissue from the cytotoxic effects of chemotherapy and radiation by amifostine (WR-2721): preclinical aspects, Eur. J. Cancer,31A(Suppl 1) (1995) 51–57.

    Google Scholar 

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Authors
  1. Edward Gillette
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  2. Barbara E. Powers
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  3. Sharon M. Gillette
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  4. Leonard L. Gunderson
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  5. Christopher G. Willett
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Editor information

Editors and Affiliations

  1. Mayo Clinic and Mayo Medical School, Rochester, MN, USA

    Leonard L. Gunderson MD, MS (Professor and Chair of Oncology) (Professor and Chair of Oncology)

  2. Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Christopher G. Willet MD

  3. Albert Einstein College of Medicine and Beth Israel Cancer Center, New York, NY, USA

    Louis B. Harrison MD

  4. University Hospital Gregorio Marañón, Madrid, Spain

    Felipe A. Calvo MD (Chair of Oncology) (Chair of Oncology)

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© 1999 Springer Science+Business Media New York

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Gillette, E., Powers, B.E., Gillette, S.M., Gunderson, L.L., Willett, C.G. (1999). Peripheral Nerve Tolerance. In: Gunderson, L.L., Willet, C.G., Harrison, L.B., Calvo, F.A. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-696-6_10

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  • DOI: https://doi.org/10.1007/978-1-59259-696-6_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5576-3

  • Online ISBN: 978-1-59259-696-6

  • eBook Packages: Springer Book Archive

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