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Gastrointestinal Endocrinology pp 215–241Cite as

Intraluminal Regulatory Peptides and Intestinal Cholecystokinin Secretion

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Part of the book series: Contemporary Endocrinology ((COE,volume 8))

Abstract

The gastrointestinal hormone cholecystokinin (CCK) was purified from porcine intestinal mucosa and sequenced almost 30 yr ago (1), yet the lack of progress in understanding how CCK secretion is regulated is apparent when one compares what is known about the regulation of gastrin secretion with that established for CCK (2,3). This is more remarkable because gastrin, which is phylogenetically CCK’s younger sibling (4), was purified and sequenced from porcine antral mucosa a few years before CCK (5). Thus, whereas neural and paracrine pathways controlling gastrin secretion have been well-established (6), the mechanisms that mediate CCK secretion from the small intestine are relatively unclear.

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Authors
  1. Alan W. Spannagel PhD
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  2. Gary M. Green PhD
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Editor information

Editors and Affiliations

  1. Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA

    George H. Greeley Jr.

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© 1999 Springer Science+Business Media New York

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Spannagel, A.W., Green, G.M. (1999). Intraluminal Regulatory Peptides and Intestinal Cholecystokinin Secretion. In: Greeley, G.H. (eds) Gastrointestinal Endocrinology. Contemporary Endocrinology, vol 8. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-695-9_9

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  • DOI: https://doi.org/10.1007/978-1-59259-695-9_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-054-0

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