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Peptide YY

  • Chapter
Gastrointestinal Endocrinology

Part of the book series: Contemporary Endocrinology ((COE,volume 8))

Abstract

Peptide YY (PYY) is one of the many peptides discovered in porcine intestinal extracts using a unique method for isolating peptides having a C-terminal amide structure (1). PYY is a 36-amino acid peptide, and is homologous to two other regulatory peptides, pancreatic polypeptide (PP) and neuropeptide Y (NPY) (2, 3) (Table 1). In humans, dogs, and rabbits, a second endogenous form, PYY (3–36), has been shown to occur in intestinal extracts or in the general circulation after a meal (4–6), PYY or PYY-like peptides have been characterized for various fish species, the frog, the lizard, and the chicken (7–13). Interestingly, chicken PYY is 37 residues in length, and the frog PYY sequence differs by only two residues from human PYY (13).

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Authors
  1. Guillermo Gomez MD
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  2. Vidyavathi Udupi PhD
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  3. George H. Greeley Jr. PhD
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Editor information

Editors and Affiliations

  1. Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA

    George H. Greeley Jr.

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Gomez, G., Udupi, V., Greeley, G.H. (1999). Peptide YY. In: Greeley, G.H. (eds) Gastrointestinal Endocrinology. Contemporary Endocrinology, vol 8. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-695-9_22

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  • DOI: https://doi.org/10.1007/978-1-59259-695-9_22

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-054-0

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