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Islet Amyloid Polypeptide and Adrenomedullin

Novel Peptide Hormones Expressed in the Gastro-Entero-Pancreatic Region

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Gastrointestinal Endocrinology

Part of the book series: Contemporary Endocrinology ((COE,volume 8))

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Abstract

Islet amyloid polypeptide (IAPP), also known by the name amylin, and adrenomedullin (ADM) are related neurohormonal peptides, which belong to the calcitonin family (Fig. 1). Structurally, IAPP is more closely related to the other peptides of the calcitonin family than is ADM. IAPP shows approx 50% homology to the calcitonin gene-related peptides (a-and 13-CGRP) and, like the CGRPs, it consists of 37 amino acids, is C-terminally amidated, and has a disulfide bridge between amino acids 2 and 7 (1). In contrast, ADM is a longer peptide, consisting of 52 or 50 amino acids in humans and rats, respectively, and its structural resemblances to the other peptides of the calcitonin family are confined to the C-terminal part of the peptide. Here, ADM displays approx 25% homology to CGRP/IAPP, the aforementioned disulfide bridge in the corresponding position, and the C-terminal amidation also being present (2).

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  1. Hindrik Mulder MD, PhD
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  1. Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA

    George H. Greeley Jr.

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Mulder, H. et al. (1999). Islet Amyloid Polypeptide and Adrenomedullin. In: Greeley, G.H. (eds) Gastrointestinal Endocrinology. Contemporary Endocrinology, vol 8. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-695-9_21

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  • DOI: https://doi.org/10.1007/978-1-59259-695-9_21

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