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Gastrointestinal Endocrinology pp 321–334Cite as

Pancreatic Polypeptide and Glucose Metabolism

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Part of the book series: Contemporary Endocrinology ((COE,volume 8))

Abstract

Pancreatic polypeptide (PP) has been scrutinized as a potential metabolic regulatory substance since its discovery. Data are now emerging that indicates PP has effects on insulin action and carbohydrate metabolism, which may be of great physiologic importance. The demonstration of such effects has been difficult despite characteristics that have invited the belief that this peptide might be a glucoregulator, namely its presence in pancreatic islets along with other substances with well-known glucoregulatory effects, and its postprandial pattern of release. Despite these characteristics, the physiologic role of PP was initially thought to involve actions such as inhibition of choleresis and exocrine pancreatic secretion through indirect effects on central and peripheral nerve fibers (1,2).

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Authors
  1. Neal E. Seymour MD
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  2. Dana K. Andersen MD
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Editor information

Editors and Affiliations

  1. Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA

    George H. Greeley Jr.

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© 1999 Springer Science+Business Media New York

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Seymour, N.E., Andersen, D.K. (1999). Pancreatic Polypeptide and Glucose Metabolism. In: Greeley, G.H. (eds) Gastrointestinal Endocrinology. Contemporary Endocrinology, vol 8. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-695-9_13

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  • DOI: https://doi.org/10.1007/978-1-59259-695-9_13

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-054-0

  • Online ISBN: 978-1-59259-695-9

  • eBook Packages: Springer Book Archive

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