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Novel Mechanisms of Estrogen Action in the Developing Brain

Role of Steroid/Neurotrophin Interactions

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Book cover Neurosteroids

Part of the book series: Contemporary Endocrinology ((COE,volume 16))

Abstract

Sex-specific and temporally restricted, differential exposure of the developing male and female central nervous system (CNS) to gonadal steroid hormones such as the estrogens and the androgens has been implicated in the organization of neural circuits controlling a broad spectrum of sexually differentiated neuroendocrine, behavioral, and cognitive functions in the mammalian adult (1–4). Paradoxically, many actions of testosterone in the developing brain depend on its initial intraneuronal conversion, through aromatiza­tion, to estradiol. Metabolic conversion results in the subsequent binding of estradiol to high-affinity intranuclear estrogen receptors (ERs) (3), that are located within neurons of brain regions such as the hypothalamus, preoptic area, cerebral cortex, hippocampus and amygdala. These are all regions that are rich in aromatase activity, particularly during development (5). Increasing evidence, however, suggests that this widely held view of estrogen action in the developing brain is too restrictive and should be expanded beyond the strict confines of sexual differentiation. Thus estrogens, and estradiol in particular, have important consequences for neuronal development, survival, regeneration, plasticity, and even aging of the mammalian CNS.

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Authors
  1. C. Dominique Toran-Allerand MD
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  1. Institut National de la Santé et de la Recherche Médicale, Collége de France, Le Kremlin-Bicêtre, France

    Etienne-Emile Baulieu MD, PhD , Paul Robel MD, PhD  & Michael Schumacher PhD ,  & 

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Toran-Allerand, C.D. (1999). Novel Mechanisms of Estrogen Action in the Developing Brain. In: Baulieu, EE., Robel, P., Schumacher, M. (eds) Neurosteroids. Contemporary Endocrinology, vol 16. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-693-5_17

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  • DOI: https://doi.org/10.1007/978-1-59259-693-5_17

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-068-7

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