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Escape of Tumors From the Immune System

Role of the Transforming Growth Factor-ß-Signaling Pathway
  • Gerard C. Blobe
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

It is widely accepted that tumors may evade the immune response by a number of different mechanisms described in Chapter 6 including: antigenic variation, downregulation of tumor-specific antigens, downregulation of major histocompatibility complex (MHC) molecules, and lack of sufficient costimulation to T cells by tumors that are considered as “self.” Mechanisms by which tumors may suppress the immune system include: interference with antigen processing and/or presentation, induction of apoptosis in lymphocytes by Fas ligand (FasL) or other “death” receptors, interference with the ability of leukocytes to migrate into the tumor, and active tumor-mediated immunosuppression. Although support for all of these mechanisms exists in experimental models and/or specific tumor types, there is mounting evidence that active tumor-mediated immunosuppression may be the most general and potent way for human tumors to escape the immune system. In addition, current evidence supports a model by which this active tumor-mediated immunosuppression is largely the result of secretion of the potent immunosuppressive cytokine, transforming growth factor-ß (TGF-ß). In this review, the evidence supporting such a role for TGF-ß and the mechanisms by which TGF-ß may be acting to suppress the immune system are discussed. Finally, strategies to target the TGFß-signaling pathway to ultimately improve the success of immunotherapy for human cancers are explored.

Keywords

Cell Growth Differ Transform Growth Factor Beta Receptor TGFbeta Signaling Soluble Extracellular Domain Local Tumor Environment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2004

Authors and Affiliations

  • Gerard C. Blobe

There are no affiliations available

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