Abstract
The progress made over the last few decades in understanding the genetic and immunological aspects of cancer has led to the development of a large number and variety of immune-based approaches to combat the disease. Among the products developed, or under development, have been receptor-targeted monoclonal antibodies (e.g., trastuzumab, tositumomab), cytokines (e.g., interferon-α [IFN-α], interleukin-2), growth factors (e.g., granulocyte-macrophage colony-stimulating factor [GM-CSF], granulocyte colony-stimulating factor [G-CSF1, erythropoietin), and an amalgam of innovative products collectively referred to as tumor vaccines.
The opinions of the authors do not necessarily reflect those of the Food and Drug Administration.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Moingeon P. Cancer vaccines. Vaccine 2001; 19:1305–1326.
Banchereau J, Steinman, RM. Dendritic cells and the control of immunity. Nature 1998; 392:245–252.
Nestle FO, Banchereau J, Hart D. Dendritic cells: on the move from bench to bedside. Nat Med 2001; 7:761–765.
Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, Marshall B, Chandler P, Antonia SJ, Burgess R, Slingluff CL Jr, Mellor AL. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 2002; 297:1867–1870.
Fong L, Hou Y, Rivas A, Benike C, Yuen A, Fisher GA, Davis MM, Engleman EG. Altered peptide ligand vaccination with Flt-3 ligand expanded dendritic cells for tumor immunotherapy. Proc Natl Acad Sci USA 2001; 98:8809–8814.
Dudley ME, Wunderlich JR, Robbins PF, Yang JC, Hwu P, Schwartzentruber DJ, Topalian SL, Sherry R, Restifo NP, Hubicki AM, Robinson MR, Raffeld M, Duray P, Seipp CA, Rogers-Freezer L, Morton KE, Mavroukakis SA, White DE, Rosenberg SA. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002; 298:850–854.
Boon T. Toward a genetic analysis of tumor rejection antigens. Adv Cancer Res 1992; 58:177–210.
Cheever MA, Disis ML, Bernhard H, Gralow JR, Hand SL, Huseby ES, Qin HL, Takahashi M, Chen W. Immunity to oncogenic proteins. Immunol Rev 1995; 145:33–59.
Old LJ, Chen YT. New paths in human cancer serology. J Exp Med 1998; 187:1163–1167.
Greenberg PD. Adoptive T cell therapy of tumors: mechanisms operative in the recognition and elimination of tumor cells. Adv Immunol 1991; 49:281–355.
Pardoll DM. Cancer vaccines: a road map for the next decade. Curr Opin Immunol 1996; 8:619–621.
Jager E, Jager D, Knuth A. Clinical cancer vaccine trials. Curr Opin Immunol 2002; 14:178–182.
Keilholz U, Weber J, Finke JH, Gabrilovich DI, Kast WM, Disis ML, Kirkwood JM, Scheibenbogen C, Schlom J, Maino VC, Lyerly HK, Lee PP, Storkus W, Marincola F, Worobec A, Atkins MB. Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy. J Immunother 2002; 25:97–138.
Okada N, Tsujino M, Hagiwara Y, Tada A, Tamura Y, Mori K, Saito T, Nakagawa S, Mayumi T, Fujita T, Yamamoto A. Administration route-dependent vaccine efficiency of murine dendritic cells pulsed with antigens. Br J Cancer 2001; 84:1564–1570.
Fong L, Brockstedt D, Benike C, Wu L, Englemen EG. Dendritic cells injected via different routes induce immunity in cancer patients. J Immunol 2001; 166:4254–4259.
Green S, Liu PY, O’Sullivan J. Factorial design considerations. J Clin Oncol 2002; 20:3424–3430.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Humana Press Inc.
About this chapter
Cite this chapter
Thornton, M.O., Worobec, A.S., Wonnacott, K., Puri, R.K. (2004). Regulatory Issues Affecting Tumor Vaccines. In: Morse, M.A., Clay, T.M., Lyerly, H.K. (eds) Handbook of Cancer Vaccines. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-680-5_37
Download citation
DOI: https://doi.org/10.1007/978-1-59259-680-5_37
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4684-9818-9
Online ISBN: 978-1-59259-680-5
eBook Packages: Springer Book Archive