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Analysis of Cellular Immune Responses in Cancer Vaccine Trials

  • Timothy M. Clay
  • Michael A. Morse
  • Paul J. Mosca
  • Amy Hobeika
  • Donna Niedzwiecki
  • H. Kim Lyerly
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Active immunotherapy seeks to stimulate therapeutic immune responses through the use of a wide variety of immunogens. Increasingly, scientific progress in the field has come to rely on the use of assays for detecting and quantifying antigen-specific immune activation and expansion, founded on the belief that these assays may be correlates of in vivo antitumor activity. This is based upon the assumption that induction of an effective antitumor immune response should lead to measurable immune responses. Assays that accurately portray the characteristics of antitumor immune responses would increase our understanding of the effector mechanisms relevant to antitumor activity and help guide the further development of the current vaccines and the next generation of immunotherapeutic strategies. Additionally, accurate immunologic assays could provide intermediate end points for the early evaluation of vaccines and vaccine adjuvants and might provide insight into clinical observations including toxicities and antitumor responses. This perceived link between immunologic assay measurements and antitumor response has not been clearly demonstrated for most current assays of cellular immunologic responses.

Keywords

Melanoma Patient Cancer Immunotherapy Cancer Vaccine ELISPOT Assay Autologous Tumor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2004

Authors and Affiliations

  • Timothy M. Clay
  • Michael A. Morse
  • Paul J. Mosca
  • Amy Hobeika
  • Donna Niedzwiecki
  • H. Kim Lyerly

There are no affiliations available

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