Vaccines for Other Tumors

  • Michael A. Morse
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Although the brain is often considered an immunologically privileged site, animal models have demonstrated immunity against brain tumors following peripheral immunizations (1), direct intracerebral injections (2), or both (3). Potential targets of immunity against gliomas include the antigens ADP-ribosylation factor 4-like (ARF4L) (4), S ART 1 (5) and SART3 (6), UDP-Gal: 3G1cNAc ß1, 3-galactosyltransferase, polypeptide 3 (7), and the vIII mutation of human epidermal growth factor receptor. Although the autoimmune condition, experimental allergic encephalomyelitis, is a theoretical risk for immunizations with central nervous system (CNS) antigens, it is believed that the use of tumor-specific antigens will limit this risk.


Human Epidermal Growth Factor Receptor Medullary Thyroid Carcinoma Experimental Allergic Encephalomyelitis Medullary Thyroid Cancer Parathyroid Carcinoma 
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© Humana Press Inc. 2004

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  • Michael A. Morse

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