T-Cell Adoptive Immunotherapy

  • Gregory E. Plautz
  • Peter A. Cohen
  • David E. Weng
  • Suyu Shu
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Adoptive transfer originally referred to the ability to confer protective immunity on a naïve host via infusion of T lymphocytes from an immune donor. This term now also encompasses a strategy of cancer therapy in which autologous T cells are acquired from a tumor-bearing host then activated and numerically expanded ex vivo prior to reinfusion. It has been nearly 50 yr since Mitchison’ s initial observation that adoptive transfer of “cellular elements” from immune hosts could accelerate rejection of tumor transplants in naïve recipients (1). Since then, considerable progress has been made in defining T lymphocytes as the central component of the antitumor response with the ability to directly kill tumor cells and orchestrate other host effector mechanisms. With the importance of T cells firmly established, tumor-reactive T-cell clones have been successfully used as probes to identify tumor-associated antigens that are currently being investigated as vaccine reagents.


Renal Cell Carcinoma Adoptive Transfer Metastatic Renal Cell Carcinoma Adoptive Immunotherapy General Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Humana Press Inc. 2004

Authors and Affiliations

  • Gregory E. Plautz
  • Peter A. Cohen
  • David E. Weng
  • Suyu Shu

There are no affiliations available

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