Gene-Modified Tumor-Cell Vaccines

  • Leisha A. Emens
  • Elizabeth M. Jaffee
Part of the Cancer Drug Discovery and Development book series (CDD&D)


The remarkable advances in biotechnology of the late 20th century created the necessary tools for further defining the principles of tumor immunology and immunotherapy. New and more efficient gene transfer technologies have been developed to enable the expression of specific immune-activating genes at desired levels by tumor cells. The ready availability of recombinant, immune-activating cytokines and chemokines has facilitated assessment of their activity delivered either systemically as a traditional drug, or by gene transfer in preclinical models and clinical trials. Dissection of the molecular mechanisms of T-cell activation has revealed a complex network of signaling pathways that integrate the positive and negative stimuli impinging on the T cell to determine its ultimate functional status. This has created a number of targets for ex vivo and in vivo manipulation to maximize vaccine-activated antitumor immune responses.


Renal Cell Carcinoma Major Histocompatibility Complex Major Histocompatibility Complex Class Antitumor Immunity Autologous Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc. 2004

Authors and Affiliations

  • Leisha A. Emens
  • Elizabeth M. Jaffee

There are no affiliations available

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