Abstract
Frontotemporal lobe degeneration (FTLD) is the term currently used for what was formerly called Pick’s disease—a condition in which behavioral symptoms (of the frontal and/or temporal lobe syndrome) precede memory loss (1). Since Pick’s bodies are found in only 25% of patients with frontotemporal dementia, the diagnosis of Pick’s disease should be reserved for pathologically confirmed cases. From a clinical perspective these cases should be referred to as frontotemporal lobe degeneration (FTLD) or frontotemporal dementia (FTD). The diagnosis of FTLD is based mainly on the clinical presentation and can be confirmed by postmortem examination (1,2). The clinical diagnosis can be supported by the performance of structural as well as functional brain imaging.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
The Lund and Manchester Groups: Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry 1994; 57: 416–418.
McKhann, G.M. et al.: Clinical and pathological diagnosis of frontotemporal dementia. Arch Neurol 2001; 58: 1803–1809.
Gustafson, L.; Brun, A.; Passant, U.: Frontal lobe degeneration of non-Alzheimer Type. In: Rossor, M.N. (ed.): Unusual dementias. Balliere Tindall, London, 1992: 559–582.
Knopman, D.S. et al.: Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia. Neurology 1990; 40: 251–256.
Neary, D.: Non Alzheimer’s disease forms of cerebral atrophy. J Neurol Neurosurg Psychiatry 1990; 53: 929–931.
Neary, D. et al.: Frontotemporal lobar degeneration. A consensus on clinical diagnostic criteria. Neurology 1998; 51: 1546–1554.
Mesulam, M.-M.: Slowly progressive aphasia without generalized dementia. Ann Neurol 1982; 11: 592–598.
Snowden, J.S.; Goulding, P.7.; Neary, D.: Semantic dementia; a form of circumscribed cerebral atrophy. Behav Neurol 1989; 2: 167–182.
Snowden, J.S.; Neary, D.; Mann, D.M.A.: Fronto-temporal lobar degeneration: fronto-temporal dementia, progressive aphasia, semantic dementia. Churchill Livingstone, London, 1996.
Rebeiz, 7.7.; Kolodny, E.H.; Richardson, E.P. Jr: Corticodentatonigral degeneration with neuronal achromasia. Arch Neurol 1968; 18: 20–33.
Houlden, H. et al. Frequency of tau mutations in three series of non-Alzheimer degenerative dementias. Ann Neurol 1999; 46: 243–248.
Poorkaj, P. et al.: Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Arch Neurol 2001; 58: 383–387.
Gydesen, S. et al.: Chromosome 3 linked frontotemporal dementia (FTD-3). Neurology 2002; 59: 1585–1594.
Swartz, J.R. et al.: Frontotemporal dementia: treatment response to serotonin reuptake inhibitors. J Clin Psychiatry 1997; 58: 212–216.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer Science+Business Media New York
About this chapter
Cite this chapter
Franczak, M., Kerwin, D., Antuono, P. (2004). Frontotemporal Lobe Dementia. In: Richter, R.W., Richter, B.Z. (eds) Alzheimer’s Disease. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-661-4_14
Download citation
DOI: https://doi.org/10.1007/978-1-59259-661-4_14
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4757-4485-9
Online ISBN: 978-1-59259-661-4
eBook Packages: Springer Book Archive