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Heart Failure in Women

Epidemiology, Gender Differences in Pathophysiology, and Implications for Therapy

  • Chapter
Coronary Disease in Women

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

In terms of morbidity, mortality, and economic expense, heart failure (HF) is a syndrome of great importance in contemporary society. Despite recent advances in the treatment of other types of heart disease, the impact of HF continues to increase. HF is now the most common reason for hospital admission in the Medicare population (1). Given the aging of the adult population (2), along with the increasing incidence and prevalence of HF with age (3), the clinical and economic burden of HF is likely to continue to rise (Fig. 1; 3a).

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References

  1. Health Care Financing Review. Statistical Supplement. US Department of Health and Human Services, Baltimore, MD, 1995, p. 56.

    Google Scholar 

  2. Foot DK, Lewis RP, Pearson TA, Beller GA. Demographics and cardiology, 1950–2050. J Am Coll Cardiol 2000; 35: 1067–1081.

    Article  PubMed  CAS  Google Scholar 

  3. Kannel WB, Belanger AJ. Epidemiology of heart failure. Am Heart J 1991;121:951–957. 3a. Bristow MR. Management of heart failure. In Braunwald E, Zipes DP, Libby P (eds.). Heart Disease: A Textbook of Cardiovascular Medicine, 6th ed. W.B. Saunders, Philadelphia, PA: 2001, pp. 635–658.

    Google Scholar 

  4. Petrie MC, Dawson NF, Murdoch DR, et al. Failure of women’s hearts. Circulation 1999; 99: 2334–2341.

    Article  PubMed  CAS  Google Scholar 

  5. Hunt SA, Baker DW, Chin MH, et al. ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). American College of Cardiology website, 2001. Available at: http://www.acc.org/clinical/guidelines/failure/hf_index.htm

    Google Scholar 

  6. Ho KKL, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: the Framingham study. J Am Coll Cardiol 1993; 22 (Suppl A): 6A - 13A.

    Article  PubMed  CAS  Google Scholar 

  7. McKee PA, Castelli WP, McNamera PM, Kannel WB. The natural history of congestive heart failure in Framingham Heart Study subjects. Circulation 1993; 88: 107–115.

    Article  Google Scholar 

  8. Kimmelstiel CD, Konstam MA. Heart failure in women. Cardiology 1995; 86: 304–309.

    Article  PubMed  CAS  Google Scholar 

  9. Kannel WB, Plehn JF, Cupples LA. Cardiac failure and sudden death in the Framingham study. Am Heart J 1988; 115: 869–875.

    Article  PubMed  CAS  Google Scholar 

  10. Levy D, Larson MG, Vasan RS, et al. The progression from hypertension to heart failure. JAMA. 1996; 275: 1557–1562.

    Article  PubMed  CAS  Google Scholar 

  11. Kimmelstiel C, Goldberg Ri. Congestive heart failure in women: focus on heart failure due to coronary artery disease and diabetes. Cardiology 1990; 77 (Suppl 2): 71–79.

    Article  PubMed  Google Scholar 

  12. Shindler DM, Kostis JB, Tusuf S, et al. Diabetes mellitus: a predictor of morbidity and mortality in the Studies of Left Ventricular Dysfunction (SOLVD) Trials and Registry. Am J Cardiol. 1996; 77: 1017–1020.

    Article  PubMed  CAS  Google Scholar 

  13. Kannel WB, Hjortland M, Castelli WP. Role of diabetes in congestive heart failure: the Framingham Heart study. Am J Cardiol 1974; 34: 29–34.

    Article  PubMed  CAS  Google Scholar 

  14. Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med 2002; 347: 305–308.

    Article  PubMed  Google Scholar 

  15. Kannel WB. Epidemiological aspects of heart failure. Cardiol Clin 1989; 7: 1–9.

    PubMed  CAS  Google Scholar 

  16. Ho KKL, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: The Framingham Study. J Am Coll Cardiol 1993; 22 (Suppl A): 6A - 13A.

    Article  PubMed  CAS  Google Scholar 

  17. Wenger NK, Speroff L, Packared B. Cardiovascular health and disease in women. N Engl J Med 1993; 329: 247–256.

    Article  PubMed  CAS  Google Scholar 

  18. Pearson GD, Veille J-C, Rahimtoola S, et al. Peripartum cardiomyopathy: National Heart, Lung, and Blood Institute and Office of Rare Diseases (National Institutes of Health) Workshop recommendations and review. JAMA 2000; 283: 1183–1188.

    Article  PubMed  CAS  Google Scholar 

  19. O’Connell JB, Costanzo-Nordin MR, Subramanian R, et al. Peripartum cardiomyopathy: clinical, hemodynamic, histologic, and prognostic characteristics. J Am Coll Cardiol 1986; 8: 52–56.

    Article  PubMed  Google Scholar 

  20. Vasan RS, Larson MG, Benjamin EJ et al. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol 1999; 1948–1955.

    Google Scholar 

  21. Aronow WS, Ahn C, Kronzon I. Normal left ventricular ejection fraction in older persons with congestive heart failure. Chest 1998; 113: 867–869.

    Article  PubMed  CAS  Google Scholar 

  22. Johnstone D, Limacher M, Rousseau M, et al. Clinical characteristics of patients in the Studies of Left Ventricular Dysfunction. Am J Cardiol 1992; 70: 894–900.

    Article  PubMed  CAS  Google Scholar 

  23. De Maria R, Gavazzi A, Recalcati F, et al. Comparison of the clinical findings in idiopathic dilated cardiomyopathy in women versus men. Am J Cardiol 1993; 72: 580–585.

    Article  PubMed  Google Scholar 

  24. Ghali JK, Cooper R, Ford E. Trends in rates for heart failure in the United States 1973–1986: evidence for increasing population prevalence. Arch Intern Med 1990; 150: 769–773.

    Article  PubMed  CAS  Google Scholar 

  25. McMurray JJV, McDonagh TA, Morrison CE, Dargie HJ. Trends in hospitalisation for heart failure in Scotland. Eur Heart J 1993; 14: 1158–1162.

    Article  PubMed  CAS  Google Scholar 

  26. Ho KKL, Anderson KM, Kannel WB, et al. Survival after the onset of congestive heart failure in Framingham Study subjects. Circulation 1993; 88: 107–115.

    Article  PubMed  CAS  Google Scholar 

  27. Schocken DD, Arieta MI, Leaverton PE, Ross EA. Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol 1992; 20: 301–306.

    Article  PubMed  CAS  Google Scholar 

  28. Adams KF, Sueta MD, Gheorghiade M, et al. Gender differences in survival in advanced heart failure: insights from the FIRST Study. Circulation 1999; 99: 1816–1821.

    Article  PubMed  Google Scholar 

  29. Simon T, Mary-Krause M, Funck-Brentano C, et al. Sex differences in the prognosis of congestive heart failure: Results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II). Circulation 2001; 103: 375–380.

    Article  PubMed  CAS  Google Scholar 

  30. Jong P, Vowinckel E, Liu PP, et al. Prognosis and determinanats of survival in patients newly hospitalized for heart failure. Arch Intern Med 2002; 162: 1689–1694.

    Article  PubMed  Google Scholar 

  31. Hinderliter AL, Light KC, Willis PW. Gender differences in left ventricular structure and function is young adults with normal or marginally elevated blood pressure. Am J Hypertens 1992; 5: 32–36.

    PubMed  CAS  Google Scholar 

  32. De Simone G, Devereux RB, Daniels SR, Meyer RA. Gender differences in left ventricular growth. Hypertension 1995 Dec; 26: 979–983.

    Article  PubMed  Google Scholar 

  33. Schaer JA, Schaible TF, Capasso J. Effects of gonadectomy and hormonal replacement on rat hearts. Cire Res 1987; 61: 12–19.

    Article  Google Scholar 

  34. Kucher N, Lipp E, Schwerzmann M, et al. Gender differences in coronary artery size per 100 g of left ventricular mass in a population without cardiac disease. Swiss Med Wkly 2001; 131: 610–615.

    PubMed  CAS  Google Scholar 

  35. Olivetti G, Diordano G, Corradi D, et al. Gender differences and aging: effects on the human heart. J Am Coll Cardiol 1995; 26: 1068–1079.

    Article  PubMed  CAS  Google Scholar 

  36. Higginbotham MB, Morris KG, Coleman RE. Sex-related differences in the normal cardiac response to upright exercise. Circulation 1984; 70: 357–366.

    Article  PubMed  CAS  Google Scholar 

  37. McGill HC, Anselmo JC, Buchannan JM, Sheridan PH. The heart is a target organ for androgen. Science Wash DC 1980; 2107: 775–777.

    Google Scholar 

  38. McGill HC, Sheridan PH. Nuclear uptake of sex steroid hormones in the cardiovascular system of the baboon. Circ Res 1981; 48: 238–244.

    Article  PubMed  CAS  Google Scholar 

  39. Rosano GM, Panina G. Cardiovascular pharmacology of hormone replacement therapy. Drugs Aging 1999; 15: 219–234.

    Article  PubMed  CAS  Google Scholar 

  40. Giraud GD, Morton MJ, Davis LE, et al. Estrogen-induced left ventricular chamber enlargement in ewes. Am J Physiol 1993; 264: E490 - E496.

    PubMed  CAS  Google Scholar 

  41. Pelzer T, Schumann M, Neumann M, et al. 1713-Estradiol prevents programmed cell death in cardiac myocytes. Biochem Biophys Res Commun 2000; 268; 192–200.

    Article  PubMed  CAS  Google Scholar 

  42. Pelzer T, Neumann M, de Jager T, et al. Estrogen effects in the myocardium: inhibition of NF-kappaB DNA binding by estrogen receptor-alpha and–beta. Biochem Biophys Res Commun 2001; 286: 1153–1157.

    Article  PubMed  CAS  Google Scholar 

  43. Francis GS, Benedict C, Johnstone DE, et al. Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfuncton (SOLVD). Circulation 1990; 82: 1724–1729.

    Article  PubMed  CAS  Google Scholar 

  44. Nickenig G, Baumer AT, Hrohe C, et al. Estrogen modulates AT1 receptor gene expression in vitro and in vivo. Circulation 1998; 97: 2197–2201.

    Article  PubMed  CAS  Google Scholar 

  45. Schunkert H, Danser AHJ, Hense HW, et al. Effects of estrogen replacement therapy on the reninangiotensin system in postmenopausal women. Circulation 1997; 95: 39–45.

    Article  PubMed  CAS  Google Scholar 

  46. Proudler AJ, Hasib AI, Crook D, et al. Hormone replacement therapy and serum angiotensin converting enzyme activity in postmenopausal women. Lancet 1995; 346: 89–90.

    Article  PubMed  CAS  Google Scholar 

  47. Kajstura J, Cigola E, Malhotra A, et al. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Cell Cardiol 1997; 29: 859–870.

    Article  CAS  Google Scholar 

  48. Ng AV, Callister R, Johnson DG, Seals DR. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension 1993; 21: 498–503.

    Article  PubMed  CAS  Google Scholar 

  49. Liao D, Barnes R, Chambless LE, et al. Age, race, and sex difference in autonomic cardiac function measured by spectral analysis of heart rate variability-The ARIC Study. Am J Cardiol 1995; 76: 906–912.

    Article  PubMed  CAS  Google Scholar 

  50. Huikuri H, Pikkujamsa S, Airaksinen KEJ, et al. Sex-related differences in autonomic modulation of heart rate in middle aged subjects. Circulation 1996; 94: 122–125.

    Article  PubMed  CAS  Google Scholar 

  51. Reis SE, Holubkov R, Young JB, et al. Estrogen is associated with improved survival in aging women with congestive heart failure: Analysis of the vesnarinone Studies. J Am Coll Cardiol 2000; 36: 529–533.

    Article  PubMed  CAS  Google Scholar 

  52. Weiner CP, Lizasoain I, Baylis SA, et al. Induction of calcium-dependent nitric oxide synthesis by sex hormones. Proc Nati Acad Sci USA 1994; 91: 5212–5216.

    Article  CAS  Google Scholar 

  53. Zhu Y, Bian Z, Lu P, et al. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science 2002; 295: 505–508.

    Article  PubMed  CAS  Google Scholar 

  54. Best PJM, Berger PB, Miller VM, Lerman A. The effects of estrogen replacement therapy on plasma nitric oxide and endothelin-l. Ann Intern Med 1998; 128: 285–288.

    PubMed  CAS  Google Scholar 

  55. Guarda E, Katwa LC, Myers PR, et al. Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovascular Res 1993; 27: 2130–2134.

    Article  CAS  Google Scholar 

  56. Carroll JD, Carroll EP, Feldman T, et al. Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation 1992; 86: 1099–1107.

    Article  PubMed  CAS  Google Scholar 

  57. Douglas PS, Katz SE, Weinberg EO, et al. Hypertrophic remodeling: Gender digfferences in the early response to left ventricular pressure overload. J Am Coll Cardiol 1998; 32: 1118–1125

    Article  PubMed  CAS  Google Scholar 

  58. Wienberg EO, Thienelt CD, Katz SE, et al. Gender differences in molecular remodeling in pressure overload hypertrophy. J Am Coll Cardiol 1999; 34: 264–273.

    Article  Google Scholar 

  59. Pfeffer JM, Pfeffer MA, Fletcher P, et al. Favorable effects of therapy on cardiac performance in spontaneously hypertensive rats. Am J Physiol 1982; 242: H776 - H784.

    PubMed  CAS  Google Scholar 

  60. Gardner JD, Brower GL, Janicki JS. Gender differences in cardiac remodeling secondary to chronic volume overload. J Cardiac Failure 2002; 8: 101–107.

    Article  Google Scholar 

  61. McKay RG, Pfeffer MA, Pasternak RC, et al. Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Ciculation 1986; 74: 693–702.

    Article  CAS  Google Scholar 

  62. Weber KT, Sun Y, Katwa LC. Wound healing following myocardial infarction. Clin Cardiol 1996; 19: 447–455.

    Article  PubMed  CAS  Google Scholar 

  63. Mendelsohn ME, Karas RH. Mechanisms of disease: the vascular protective effects of estrogen. N Engl J Med 1999; 340: 1801–1811.

    Article  PubMed  CAS  Google Scholar 

  64. Udelson JE, Kronenberg MW, Rousseau MF, et al. for the SOLVD Investigators. Determinants of progressive left ventricular dilatation in patients with left ventricular systolic dysfunction. Circulation 1992; 86: I - 251.

    Google Scholar 

  65. Ebert S, Liu X-K, Woosley R. Female gender as a risk factor for drug-induced cardiac arrhythmias: Evaluation of clinical and experimental evidence. J Women’s Health 1998; 7: 547–557.

    Article  PubMed  CAS  Google Scholar 

  66. Lehmann MH, Hardy S, Archibald D, et al. Sex difference in risk of torsade de pointes with d,lsotalol. Circulation 1996; 94: 2535–2541.

    Article  PubMed  CAS  Google Scholar 

  67. Schatzkin A, Cupple A, Heeren T, et al. Framingham heart study. Am J Epidemiol 1984; 120: 888–899.

    PubMed  CAS  Google Scholar 

  68. Myerburg R. Epidemiology of ventricular tachycardia/fibrillation and sudden cardiac death. PACE 1986; 9: 1334–1338.

    Article  PubMed  CAS  Google Scholar 

  69. Benjamin EJ, Levy D, Vaziri SM, et al. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA 1994 Mar 16; 271: 840–844.

    Article  Google Scholar 

  70. Wolbrette D, Naccarelli G, Curtis A, et al. Gender differences in arrhythmias. Clin Cardiol 2002; 25: 49–56.

    Article  PubMed  Google Scholar 

  71. Clinical Quality Improvement Network Investigators. Mortality risk and patterns of practice in 4606 acute care patients with congestive heart failure. The relative importance of age, sex, and medical therapy. Arch Int Med 1996; 156: 1669–1673.

    Article  Google Scholar 

  72. Vaccarino V, Chen YT, Wang Y, et al. Sex differences in the clinical care and outcomes of congestive heart failure in the elderly. Am H J 1999; 135: 835–842.

    Article  Google Scholar 

  73. Ayanian JZ, Epstein AM. Differences in the use of procedures between women and men hospitalized for coronary heart disease. N Engl J Med 1991; 325: 221–225.

    Article  PubMed  CAS  Google Scholar 

  74. Philbin EF, DiSalvo TG. Influence of race and gender on care process, resource use, and hospital-based outcomes in congestive heart failure. Am J Cardiol 1998; 82: 76–82.

    Article  PubMed  CAS  Google Scholar 

  75. Aaronson KD, Schwartz JS, Goin JE, Mancini DM. Sex differences in patient acceptance of cardiac transplant candidacy. Circ 1995; 91: 2753–2761.

    Article  CAS  Google Scholar 

  76. Crandall BG, Renland DG, O’Connell JB, et al. Increased frequency of cardiac allograft rejection in female heart transplant recipients. J Heart Lung Transplant 1988; 7: 419–423.

    CAS  Google Scholar 

  77. Hosenpud JD, Novick RJ, Breen Ti, Daily OP. The Registry of the International Society for Heart and Lung Transplantation: Eleventh Official Report-1994. J Heart Lung Trans 1994; 13: 561–570.

    CAS  Google Scholar 

  78. Schwartz JB. Congestive heart failure medications: Is there a rationale for sex-specific therapy? J Gender-Specific Med 2000; 3: 17–22.

    CAS  Google Scholar 

  79. Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 1995; 273: 1450–1456.

    Article  PubMed  CAS  Google Scholar 

  80. Konstam MA, Kronenberg MW, Rousseau MF, et al. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. Circulation 1993; 88: 2277–2283.

    Article  PubMed  CAS  Google Scholar 

  81. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987; 316: 1429–1435.

    Article  Google Scholar 

  82. Pfeffer MA, Braunwald E, Moye LA, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med 1992; 327: 669–677.

    Article  PubMed  CAS  Google Scholar 

  83. The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991; 325: 293–302.

    Article  Google Scholar 

  84. Pitt B, Segal R, Martinez FA, et al. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet 1997; 349: 747–752.

    Article  PubMed  CAS  Google Scholar 

  85. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial - the losartan heart failure survival study ELITE II. Lancet 2000;355:1582–1587.

    Google Scholar 

  86. Goldstein S. Benefits of 13-blocker therapy for heart failure. Arch Int Med 2002; 162: 641–648.

    Article  CAS  Google Scholar 

  87. Foody JM, Farrell MH, Krumholz HM. ß-blocker therapy in heart failure. Scientific Review. JAMA 2002; 287: 883–889.

    Article  PubMed  CAS  Google Scholar 

  88. The Beta-Blocker Evaluation of Survival Trial Investigators. A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure. N Eng J Med 2001; 344: 1659–1667.

    Article  Google Scholar 

  89. Hjalmarson A, Goldstein S, Fagerberg B, et al. Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure. The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF). JAMA 2000; 283: 1295–1302.

    Article  PubMed  CAS  Google Scholar 

  90. Packer M, Coats AJS, Fowler MB, et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001; 344: 1651–1658.

    Article  PubMed  CAS  Google Scholar 

  91. Ghali JK, Pina IL, Gotleib SS, Deedwania PC, Wikstrand JC; on behalf of the MERIT-HF Study Group. Metoprolol CR/XL in female patients with heart failure: analysis of the experience in metoprolol extended-release randomized intervention trial in heart failure (MERIT-HF). Circulation 2002; 105: 1585–1591.

    Article  PubMed  Google Scholar 

  92. Dries DL, Rosenberg YD, Waclawiw MA, Domanski MJ. Ejection fraction and risk of thromboembolic events in patients with systolic dysfunction and sinus rhythm: evidence for gender differences in the Studies of Left Ventricular Dysfunction trials. J Am Coll Cardiol 1997; 29: 1074–1080.

    Article  PubMed  CAS  Google Scholar 

  93. Koniaris LK, Goldhaber SZ. Anticoagulation in dilated cardiomyopathy. J Am Coll Cardiol 1998; 31: 745–748.

    Article  PubMed  CAS  Google Scholar 

  94. Yamamoto K, Ikeda U, Furuhashi K, et al. The coagulation system is activated in idiopathic cardiomyopathy. J Am Coll Cardiol 1995; 25: 1634–1640.

    Article  PubMed  CAS  Google Scholar 

  95. al-Khadra AS, Salem DN, Rand WM, et al. Warfarin anticoagulation and survival: a cohort analysis from the Studies of Left Ventricular Dysfunction. J Am Coll Card 1998; 31: 749–753.

    Article  CAS  Google Scholar 

  96. Grodstein F, Stampfer MJ, Manson JE, et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 1996; 335: 453–461.

    Article  PubMed  CAS  Google Scholar 

  97. Grady D, Rubin SM, Petitti DB, et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Int Med 1992; 117: 1016–1037.

    PubMed  CAS  Google Scholar 

  98. Grady D, Herrington D, Bittner V, et al. for the HERS Research Group. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/Progestin Replacement Study follow-up (HERS II). JAMA 2002; 288: 49–57.

    Article  PubMed  Google Scholar 

  99. Hulley S, Furberg C, Barrett-Connor E, et al. for the HERS Research Group. Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/Progestin Replacement Study Follow-up (HERS II). JAMA 2002; 288: 58–66.

    Article  PubMed  CAS  Google Scholar 

  100. Barrett-Connor E, Grady D, Sashegyi A, for the MORE Investigators (Multiple Outcomes of Raloxifene Evaluation). Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial. JAMA 2002; 287: 847–857.

    Article  PubMed  CAS  Google Scholar 

  101. Mosca L, Barrett-Connor E, Wenger NK, et al. Design and methods of the Raloxifene Use for The Heart (RUTH) study. Am J Cardiol 2001; 88: 4 392–395

    Article  PubMed  CAS  Google Scholar 

  102. Thurmann PA, Hompesch BC. Influence of gender on the pharmacokinetics and pharmacodynamics of drugs. Int J Clin Pharma Therapeutics 1998; 36: 586–590.

    CAS  Google Scholar 

  103. Charney P, Meyer BR, Frishman WH, et al. Gender, race, and genetic issues in cardiovascular pharmacotherapeutics. In: Frishman WH, Sonnenblick EH, eds. Cardiovascular Pharmacotherapeutics. McGraw-Hill, New York, 1997, pp. 1347–1361.

    Google Scholar 

  104. Greenberg A. Diuretic complications. Am J Med Sci 2000; 319: 10–24.

    Article  PubMed  CAS  Google Scholar 

  105. Kubota K, Kubota N, Pearce GL, Inman WH. ACE-inhibitor-induced cough, an adverse drug reaction unrecognised for several years: studies in prescription-event monitoring. Eur J Clin Pharmacol 1996; 49: 431–437.

    Article  PubMed  CAS  Google Scholar 

  106. Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999; 341: 709–717.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Daniel P. Morin MD, MPH
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  2. Marvin A. Konstam MD
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  3. Michael E. Mendelsohn MD
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  4. James E. Udelson MD
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Editors and Affiliations

  1. Outcomes Research, American Cardiovascular Research Institute, Atlanta, GA, USA

    Leslee J. Shaw PhD

  2. Division of Cardiology, University of California School of Medicine, San Francisco, CA, USA

    Rita F. Redberg MD, FACC

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Morin, D.P., Konstam, M.A., Mendelsohn, M.E., Udelson, J.E. (2004). Heart Failure in Women. In: Shaw, L.J., Redberg, R.F. (eds) Coronary Disease in Women. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-645-4_6

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  • DOI: https://doi.org/10.1007/978-1-59259-645-4_6

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