Abstract
The appropriate proliferation and differentiation of cells during development, and the maintenance of cellular homeostasis in the adult require a continuous flow of information to the cell. This is provided either by diffusible signaling molecules, or by direct cell-cell and cell-matrix interactions. All cells utilize a wide variety of signaling molecules and signal transduction systems to communicate with one another, but within the vertebrate endocrine system, it is the secreted hormones that are classically associated with cellular signaling. Hormones are chemical messengers produced from the endocrine glands that act either locally or at a distance to regulate the activity of a target cell. As discussed in detail elsewhere within this volume, prominent groups of hormonal agents include the peptide hormones, the steroid, retinoid and thyroid hormones, the growth factors, the cytokines, the pheromones, and the neurotransmitters or neuromodulators.
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References
Berridge MJ. Inositol triphosphate and calcium signaling. Nature 1993; 361: 315.
Bock KW. Aryl hydrocarbon or dioxin receptor: biologic and toxic responses. Rev Physiol Biochem Pharmacol 1993; 125: 1.
Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232: 34.
Burbach KM, Poland A, Bradfield CA. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci USA 1992; 89: 8185.
Carbone M, Levine A. Oncogenes, antioncogenes, and the regulation of cell growth. Trends Endocrinol Metab 1990; 1: 248.
Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to INFs and other extracellular signaling proteins. Science 1994; 265: 1415.
Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ. Model systems for the study of seven-transmembrane-segment receptors. Ann Rev Biochem 1991; 60: 653.
Drewett JG, Garbers DL. The family of guanylyl cyclase receptors and their ligands. Endoc Rev 1994; 15: 135.
Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889.
Fischer EH, Charbonneau H, Tonks NK. Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science 1991; 253: 401.
Fuh G, Cunningham BC, Fukunaga R, Nagata S, Goeddel DV, Wells JA. Rational design of potent antagonists to the human growth hormone receptor. Science 1992; 256: 1677.
Gilman AG. G proteins; transducers of receptor-generated sig nals. Ann Rev Biochem 1987; 56: 615.
Glass CK. Differential recognition of target genes by nuclear receptor monomers, dimers and heterodimers. Endoc Rev 1994; 15: 391.
Ihle JN, Kerr IM, Jaks and stats in signaling by the cytokine receptor superfamily. Trends Genetics 1995; 11: 69
Jensen EV, Jacobson HI. Basic guide to the mechanism of estrogen action. Rec Prog Hormone Res 1962; 18: 387.
Kolakowski LF. GCRDb: a G-protein-coupled receptor database. Receptors and Channels 1994; 2: 1.
Krebs EG. Protein phosphorylation and celular regulation. Bioscience Reports 1993; 13: 127.
Langley JN. On nerve endings and on special excitable substances in cells. Proc Royal Soc Lond 1906; 78: 170.
Lefkowitz RJ. G protein-coupled receptor kinases. Cell 1993; 74: 409.
Mathews LS. Activin receptors and cellular signaling by the receptor serine kinase family. Endoc Rev 1994; 15: 310.
Myers MG Jr, White MF. New frontiers in insulin receptor sub- strate signaling. Trends Endocrinol Metab 1995; 6: 209.
O’Malley BW, Schrader WT, Mani S, Smith C, Weigel NL, Conneely OM, Clark JH. An alternative ligand-independent pathway for activation of steroid receptors. Rec Prog Hormone Res 1995; 50: 333.
Pawson T. Protein modules and signaling networks. Nature 1995; 373: 573.
Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci 1949; 51: 660.
Schlessinger J, Ullrich A. Growth factor signaling by receptor tyrosine kinases. Neuron 1992; 9: 383.
Sutherland EW. Studies on the mechanism of hormone action. Science 1972; 177: 401.
Swanson HI, Bradfield CA. The Ah receptor: genetics, structure and function. Pharmacogenetics 1993; 3: 213.
Toft D, Gorski J. A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization. Proc Natl Acad Sci USA 1966; 55: 1574.
Unwin N. Neurotransmiter action: opening of ligand-gated ion channels. Neuron 1993; 10 (Suppl): 31.
van der Geer P, Hunter T, Lindberg RA. Receptor protein-tyrosine kinases and their signal transduction pathways. Ann Rev Cell Biol 1994; 10: 251
Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. Mechanism of activation of the TGF-fì receptor. Nature 1994; 370: 341.
Selected Readings
Gammeltoft S, Kahn CR. Hormone signaling via membrane receptors. In: DeGroot LJ, ed. Endocrinology. Philadelphia: Saunders, 1995: 17.
Kornfield S. Structure and function of the mannose6-phosphate/insulin-like growth factor II receptors. Ann Rev Biochem 1992; 61: 307.
Mayo KE, Park-Sarge O-K. Molecular biology of endocrine receptors in the ovary. In: Findlay JK, ed. Molecular Biology of the Female Reproductive System. San Diego: Academic 1994: 153.
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Mayo, K.E. (1997). Receptors. In: Conn, P.M., Melmed, S. (eds) Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-641-6_2
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DOI: https://doi.org/10.1007/978-1-59259-641-6_2
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