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Gene Therapy for Pain

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Book cover Gene Therapy for Neurological Disorders and Brain Tumors

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Pain is a common symptom in a variety of medical and neurologic diseases. Frequently, pain is due to tissue injury and serves to protect us from further harm, during which time healing can occur (1). This acute pain is often short-lived and can be effectively treated with analgesic medications such as opioids and nonsteroidal anti-inflammatory agents. In some instances, pain may persist as a consequence of a chronic process such as inflammation (2), invasion by tumor (3), or degeneration (4). Patients with these types of chronic pain consume large amounts of analgesics that are often ineffective for their pain, or which have undesirable, dose-related, side-effects. Chronic pain may also develop after damage to central or peripheral somatosensory pathways in humans (5). This neuropathic pain is often severe, persistent and resistant to treatment with any analgesic medication. Gene-based therapies for pain offer a potential alternative for the treatment of pain due to chronic disease or somatosensory injury. Using this approach, treatment can potentially be targeted to the site of injury, or within pain pathways, inducing analgesia without systemic side effects. Successful treatment with gene-based therapies for pain may also reduce the requirement for continuous or repeated administration of analgesics in patients with chronic pain.

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Authors
  1. Gudarz Davar
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Editors and Affiliations

  1. Molecular Neuro-Oncology, Neurosurgical Service, Massachussetts General Hospital, Harvard Medical School, Boston, MA, USA

    E. Antonio Chiocca MD, PhD

  2. Neurogenetics Unit, Massachussetts General Hospital, Harvard Medical Center, Boston, MA, USA

    Xandra O. Breakefield PhD

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Davar, G. (1998). Gene Therapy for Pain. In: Chiocca, E.A., Breakefield, X.O. (eds) Gene Therapy for Neurological Disorders and Brain Tumors. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-478-8_20

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  • DOI: https://doi.org/10.1007/978-1-59259-478-8_20

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5314-1

  • Online ISBN: 978-1-59259-478-8

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