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Glutamatergic Receptor Agonists and Brain Pathology

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Highly Selective Neurotoxins

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Excitatory amino acids (EAAs) represent a major group of neurotoxic agents, primarily affecting the nerve cell body. The beginning of the excitotoxicity era can be traced back to early 1950s when Hayashi described convulsant properties of l-glutamic acid (GLU) and l-aspartic acid (ASP) following their administration into the cerebral cortex of dogs and monkeys (1). Later, Lucas and Newhouse reported that systemic GLU destroyed inner layers of immature mouse retina (2). Excitatory properties of GLU within the central nervous system (CNS) were described by Curtis and Watkins in 1959 (3,4). This inspired further studies on GLU and its derivatives, which ultimately led to consensus that GLU is a principal excitatory neurotransmitter acting at a majority of EAA synapses, which are present on practically every neuron in the CNS.

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Authors
  1. Ewa M. Urbanska
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  2. Andrzej Dekundy
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  3. Zdzislaw Kleinrok
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  4. Waldemar A. Turski
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  5. Stanislaw J. Czuczwar
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  1. Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA

    Richard M. Kostrzewa

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Urbanska, E.M., Dekundy, A., Kleinrok, Z., Turski, W.A., Czuczwar, S.J. (1998). Glutamatergic Receptor Agonists and Brain Pathology. In: Kostrzewa, R.M. (eds) Highly Selective Neurotoxins. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-477-1_13

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