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Neuropathology of Dopaminergic Transplants in Patients with Parkinson’s Disease

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Cell Transplantation for Neurological Disorders

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Parkinson’s disease (PD) is an idiopathic, chronic neurodegenerative disorder that predominantly affects individuals in their fifth and sixth decades of life. Clinical symptoms include tremor, bradykinesia, and rigidity, all of which invariably increase in severity as the disease progresses with time. Pathologically, there is progressive degeneration of dopaminergic neurons within the substantia nigra pars compacta. This degeneration results in pronounced deficits in striatal dopamine. The presence of laminated inclusions (Lewy bodies) is also a hallmark neuropathological feature of this disease. Palliative symptomatic treatment can be achieved by dopamine replacement therapy using the dopamine precursor, l-DOPA (Sinemet), or dopamine receptor agonists (1). However, symptomatic treatments become complicated by “wearing off effects” with disabling dyskinesias. Furthermore, as PD progresses, motor and nonmotor symptoms emerge that are not responsive to l-DOPA. Since treated patients show a life expectancy similar to that seen in age-matched controls, patients can survive with crippling symptoms for many years. Thus, new innovative treatment strategies are needed to sustain the quality of life for these individuals.

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Authors
  1. Jeffrey H. Kordower
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  2. Rose Hanbury
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  3. Krzysztof S. Bankiewicz
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Editors and Affiliations

  1. Division of Neurosurgery, Department of Pharmacology and Experimental Therapeutics, The Neuroscience Program, University of South Florida, Tampa, FL, USA

    Thomas B. Freeman MD

  2. Departments of Clinical Neurosciences and Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    Håkan Widner MD, PhD

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Kordower, J.H., Hanbury, R., Bankiewicz, K.S. (1998). Neuropathology of Dopaminergic Transplants in Patients with Parkinson’s Disease. In: Freeman, T.B., Widner, H. (eds) Cell Transplantation for Neurological Disorders. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-476-4_5

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  • DOI: https://doi.org/10.1007/978-1-59259-476-4_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-043-4

  • Online ISBN: 978-1-59259-476-4

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