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Toward a Phase III Multicenter Study of Fetal Ventral Mesencephalic Transplants in Patients with Late-Stage Parkinson’s Disease

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Cell Transplantation for Neurological Disorders

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

After more than half a dozen years of extremely careful experimental application of fetal neural transplants in patients with late-stage Parkinson’s disease (PD), the time may now have come to organize the next step to be taken to establish this technique as a therapeutic, i.e., to set up a large-scale phase III multicenter study.

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References

  1. Lindvall, O., Brundin, P., Widner, H., Rehncrona, S., Gustavii, B., Frackowiack, R., et al. (1990) Grafts of fetal dopamine neurons survive and improve motor function in Parkinson’s disease. Science 247, 574–577.

    Article  PubMed  CAS  Google Scholar 

  2. Lindvall, O., Widner, H., Rehncrona, S., Brundin, P., Odin, P., Gustavii, B. et al. (1992) Transplantation of fetal dopamine neurons in Parkinson’s disease, one-year clinical and neurophysiological observations in two patients with putaminal implants. Ann. Neurol. 31, 155–165.

    Article  PubMed  CAS  Google Scholar 

  3. Lindvall, O., Sawle, G., Widner, H., Rothwell, J. C., Björklund, A., Brooks, D., et al. (1994) Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson’s disease. Ann. Neurol. 35, 172–180.

    Article  PubMed  CAS  Google Scholar 

  4. Sawle, G. V., Bloomfield, P. M., Björklund, A., Brooks, D. J., Brundin, P., Leenders, K. L. et al. (1992) Transplantation of fetal dopamine neurons in Parkinson’s disease: PET [18F]-6-L-fluorodopa studies in two patients with putaminal implants. Ann. Neurol. 31, 166–173.

    Article  PubMed  CAS  Google Scholar 

  5. Freeman, T. B., Olanow C. W., Hauser, R. A., Nauert, G. M., Smith, D. A. et al. (1995) Bilateral fetal nigral transplantation into the post commissural putamen in Parkinson’s diseases. Ann. Neurol. 38, 379–388.

    Article  PubMed  CAS  Google Scholar 

  6. Peschanski, M., Defer, G., Nguyen, J. P., Ricolfi, F., Monfort, J. C., Remy, P., et al. (1994) Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson’s disease following intrastriatal transplantation of fetal ventral mesencephalon. Brain 117, 487–499.

    Article  PubMed  Google Scholar 

  7. Rémy, Ph., Samson, Y., Hantraye, Ph., Fontaine, A., Defer, G., Mangin, J. F., et al. (1995) Neural grafting in five parkinsonian patients: correlations between PET and clinical evolution. Ann. Neurol. 38, 580–588.

    Article  PubMed  Google Scholar 

  8. Defer, G., Geny, C., Ricolfi, F., Fenelon, G., Monfort, J.C., Remy, P., et al. (1996) Longterm outcome of unilaterally transplanted parkinsonian patients: I: clinical approach. Brain 119, 41–50.

    Article  PubMed  Google Scholar 

  9. Kordower, J. H., Freeman, T. B., Snow, B. J., Vingerhoets, F. J. G., Mufson, E. J., Sanberg, P. R., et al. (1995) Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson’s disease. N. Engl. J. Med. 332, 1118–1124.

    Article  PubMed  CAS  Google Scholar 

  10. Leroy, A., Michelet, D., Mahieux, F., Geny, C., Defer, G., Monfort, J. C., et al. (1996) Suivi neuropsychologique de 5 patients parkinsoniens après greffe neuronale. Rev. Neurol. 152, 158–164.

    PubMed  CAS  Google Scholar 

  11. Sass, K. J., Buchanan, C. P., Westerveld, M., Marek, K. L., Farhi, A., Robbins, E. J. et al. (1995) General cognitive ability following unilateral and bilateral fetal ventral mesencephalic tissue transplantation for treatment of Parkinson’s Disease. Arch. Neurol. 52, 680–686.

    Article  PubMed  CAS  Google Scholar 

  12. Lindvall, O. (1994) Neural transplantation in Parkinson’s disease, in Functional Neural Transplantation ( Dunnett, S. B. and Björklund, A., eds.), Raven, New York, pp. 103–137.

    Google Scholar 

  13. Olanow, C. W., Kordower, J. H., and Freeman, T. B. (1996) Fetal nigral transplantation as a therapy for Parkinson’s disease. TINS 19, 102–109.

    PubMed  CAS  Google Scholar 

  14. Spencer, D. D., Robbins, R. J., Naftolin, F., Phil, D., Marek, K. L., Vollmer, T., et al. (1992) Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson’s disease. N. Engl. J. Med. 327, 1541–1548.

    Article  PubMed  CAS  Google Scholar 

  15. Isacson O, personal communication.

    Google Scholar 

  16. Lopez-Lozano, J. J., Bravo, G., and Brera, B. (1991) Can an analogy be drawn between the clinical evolution of Parkinson’s patients who undergo autoimplantation of adrenal medulla and those of fetal ventral mesencephalon transplant recipients? in Intracerebral Transplantation in Movement Disorders. Restorative Neurology, vol. 4 ( Lindvall, O., Björklund, A., and Widner, H., eds.), Elsevier, Amsterdam, pp. 87–98.

    Google Scholar 

  17. Freed, C. R., Breeze, R. E., Rosenberg, N. L., Schneck, S. A., Wells, T. H., Barrett, J. N., et al. (1990) Transplantation of human fetal dopamine cells for Parkinson’s disease. Arch. Neurol. 47, 505–512.

    Article  PubMed  CAS  Google Scholar 

  18. Freed, C. R., Breeze, R. E., Rosenberg, N. L., Schneck, S. A., Kriek, E., Qi, J. X., et al. (1992) Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson’s disease. N. Engl. J. Med. 327, 1549–1555.

    Article  PubMed  CAS  Google Scholar 

  19. Björklund, A., Dunnett, S. B., and Nikkhah, G. (1994) Nigral transplants in the rat Parkinson model. Functional limitations and strategies to enhance nigrostriatal reconstruction, in Functional Neural Transplantation ( Dunnett, S. B. and Björklund, A., eds.), Raven, New York, pp. 47–69.

    Google Scholar 

  20. Brundin, P., Duan, W. M., and Sauer, H. (1994) Functional effects of mesencephalic dopamine neurons and adrenal chromaffin cells grafted to the rodent striatum, in Functional Neural Transplantation ( Dunnett, S. B. and Björklund, A. eds.), Raven, New York, pp. 9–46.

    Google Scholar 

  21. Brundin, P., Nilsson, O. G., Strecker, R. E., Lindvall, O., Astedt, B., and Björklund, A. (1986) Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson’s disease. Exp. Brain Res. 65, 235–240.

    Article  PubMed  CAS  Google Scholar 

  22. Brundin, P., Strecker, R. E., Widner, H., Clarke, D. J., Nilsson, O. G., Astedt, B., et al. Human fetal dopamine neurons grafted in a rat model of Parkinson’s disease: Immunological aspects, spontaneous and drug-induced behaviour, and dopamine release. Exp. Brain Res. 70, 192–208.

    Google Scholar 

  23. Freeman, T. B., Spence, M. S., Boss, B. D., Spector, D. H., Strecker, R., Olanow, C. W., et al. (1991) Development of dopaminergic neurons in the human substantia nigra. Exp. Neurol. 113, 344–353.

    Article  PubMed  CAS  Google Scholar 

  24. Cadusseau, J., Jény, R., Hammami, M., and Peschanski, M. (1991) First weeks of development of central catecholaminergic (CA) neurons in the human embryo. Neurosci. Abstracts 17, 769.

    Google Scholar 

  25. Verney, C., Zecevic, N., Nicolic, B., Alvarez, C., and Berger, B. (1991) Early evidence of catecholaminergic cell groups in 5- and 6-week-old human embryos using tyrosine hydroxylase and dopamine-ß-hydroxylase immunocytochemistry. Neurosci. Lett. 131, 121–124.

    Article  PubMed  CAS  Google Scholar 

  26. Zecevic, N. and Verney C. (1995) Development of the catecholamine neurons in human embryos and fetuses, with special emphasis on the innervation of the cerebral cortex. J. Comp. Neurol. 351, 509–535.

    Article  PubMed  CAS  Google Scholar 

  27. Silani, V., Mariani, D., Donato, F. M., Ghezzi, C., Mazzuchelli, F., Buscaglia, M., et al. (1994) Development of dopaminergic neurons in the human mesencephalon and in vitro effects of basic fibroblast growth factor treatment. Exp. Neurol. 128, 59–76.

    Article  PubMed  CAS  Google Scholar 

  28. Almqvist, P. M., Akesson, E., Wahlberg, L., Pschera, H., Seiger, A., et al. (1996) First trimester development of the human nigrostriatal dopamine system. Exp. Neurol. 139, 227–237.

    Article  PubMed  CAS  Google Scholar 

  29. Freeman, T. B., Sanberg, P. R., Nauert, G. M., Boss, B. D., Spector, D., Olanow, C. W., et al. (1995) The influence of donor age on the survival of solid and suspension intrapenchymal human embryonic nigral grafts. Cell Transplant. 4, 141–154.

    Article  PubMed  CAS  Google Scholar 

  30. Jény, R., Peschanski, M., and Cynober, E. (1993) Apport de l’échographie dans les prélevements embryonnaires a visée de greffes intracérébrales dans le traitement de la maladie de Parkinson. JEMU 14, 19–22.

    Google Scholar 

  31. Kordower, J. H., Rosenstein, J. M., Collier, T. J., Burke, M. A., Chen, E. Y., Lu, J. M., et al. (1996) Functional fetal nigral grafts in a patient with Parkinson’s disease: chemoanatomic, ultrastructural, and metabolic studies. J. Comp. Neurol. 370, 203–230.

    Article  PubMed  CAS  Google Scholar 

  32. Nguyen, J. P., Keravel, Y., Yuichi, A., Takenobu, A., Peschanski, M., Rostaing, S., et al. (1995) Intrastriatal grafts of fetal mesencephalic neurons in five parkinsonian patients. Function Neurosurg. 33, 7–13.

    Google Scholar 

  33. Widner, H., Tetrud, J., Rehncrona, S., Snow, B., Brundin, P., Gustavii, B., et al. (1992) Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. N. Engl. J. Med. 327, 1556–1563.

    Article  PubMed  CAS  Google Scholar 

  34. Langston, W. J., Widner, H., Goetz, C. G., Brooks, D., Fahn, S., Freeman, T., et al. (1992) Core assessment program for intracerebral transplantations (CAPIT). Mov. Disord. 7, 2–13.

    Article  PubMed  CAS  Google Scholar 

  35. Lindvall, O., Rehncrona, S., Brundin, P., et al. (1989) Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson’s disease: a detailed account of methodology and a 6 month follow-up. Arch. Neurol. 46, 615–631.

    Article  PubMed  CAS  Google Scholar 

  36. NECTAR (1994) NIH neural transplantation funding. Science 263, 737.

    Google Scholar 

  37. Freeman, T. B., Vawter, D., Goetz, C. G., Hauser, R. A., Kordower, J. H., Sanberg, P. R., et al. (1995) The use of a cosmetic surgical placebo controlled trial in the treatment of Parkinson’s disease. Neurosci. Abstracts 21, 1756.

    Google Scholar 

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Authors
  1. Marc Peschanski
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  2. Gilles Defer
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  3. Sophie Dethy
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  4. Philippe Hantraye
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  5. Marc Levivier
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  6. Jean-Paul Nguyen
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  7. Pierre Cesaro
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Editor information

Editors and Affiliations

  1. Division of Neurosurgery, Department of Pharmacology and Experimental Therapeutics, The Neuroscience Program, University of South Florida, Tampa, FL, USA

    Thomas B. Freeman MD

  2. Departments of Clinical Neurosciences and Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    Håkan Widner MD, PhD

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© 1998 Springer Science+Business Media New York

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Peschanski, M. et al. (1998). Toward a Phase III Multicenter Study of Fetal Ventral Mesencephalic Transplants in Patients with Late-Stage Parkinson’s Disease. In: Freeman, T.B., Widner, H. (eds) Cell Transplantation for Neurological Disorders. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-476-4_3

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  • DOI: https://doi.org/10.1007/978-1-59259-476-4_3

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-043-4

  • Online ISBN: 978-1-59259-476-4

  • eBook Packages: Springer Book Archive

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